Biomedical subjects
Publications and source records attributed to B Kahveci.
Fourteen new potentially biologically active 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analysis, 1H NMR, IR and UV spectra. Three of these compounds were screened for their antitumor activities.
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.