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Biomedical subjects

B Kanceljak-Macan

Publications and source records attributed to B Kanceljak-Macan.

10 recordsLinked to original sources
PubMed1992

[Epidemiologic and sociologic aspects of occupational bronchial asthma].

The main problems confronted in epidemiological investigations of occupational bronchial asthma are described, such as the absence of a definition of the disease, the need for a standardized questionnaire for the symptoms of the disease and the heterogeneity of the functional lung tests. The questionnaires most frequently used for respiratory symptoms and the most suitable tests for measuring and evaluating ventilatory lung function are discussed. The problem of identifying the persons who are at risk of developing occupational bronchial asthma is also dealt with.

Asthma↗
PubMed1989

[Reevaluation of work disability in chronic bronchitis and functional criteria at rest].

As part of an investigation to reassess disability which was performed in 579 subjects with an internist's diagnosis, disability was reassessed in 68 males with chronic bronchitis as the main diagnosis. Disability reassessment was carried out by an informal team of physicians consisting of pulmologists and members of a second degree disability board. The aim of the study was to define the differences between disability reevaluation and residual working capacity. In. chronic bronchitics, a complete functional pulmonary test was carried out including measurement of the degree of obstruction, several specific parameters, non-specific bronchial reactivity and an analysis of arterial blood gases. Disability was reassessed in accordance with the following parameters: accurate evaluation, inaccurate evaluation, residual working capacity, uncompleted treatment. The one-way Kruskal-Wallis rank analysis of non-parametric data attributed the following predictors as specific: age, PC20, FEV1, the condition of hyperreactive airways and the degree of airway obstruction. The relevance of functional criteria ar rest, particularly of FEV1, for assessing the loss of working capacity in persons with chronic obstructive bronchitis is emphasized.

Bronchitis↗
PubMed1989

[Skin reactivity to grass pollen and the mite Dermatophagoides pteronyssinus in the prick-test using 2 types of allergen preparations].

The reliability of prick testing with allergen preparations produced in Yugoslavia was assessed by comparison to the internationally accepted ones (Pharmacia Diagnostica) of 100,000 BU activity. The following allergens were used: the mite Dermatophagoides pteronyssinus in 107 subjects, and grass pollens: Dactylis glomerata, Poa pratensis, Phleum pratense and Secale cereale in 39 subjects. The clinical significance of the response was assessed in relation to the skin reaction to the negative control solution and positive histamine control (in concentration of 1 mg/ml). The results indicate that the allergen extract of Dermatophagoides pteronyssinus (3000 PNU/ml) produced in Yugoslavia does not provoke skin reactions comparable to those provoked by the standardized extract of 100,000 BU in contrast to the grass pollen allergens, with the exception of Poa pratensis, which evokes equivalent skin reactions. Thus grass pollen allergens are reliable extracts and can be applied with good confidence in routine work. The need to set more rigorous criteria for assessing skin prick reactions, when domestic, unstandardized products are used, emerged as a result of this study.

Allergens↗
PubMedDate not supplied

[The effect of the length of exposure and smoking on respiratory function in workers exposed to asbestos-cement dust].

Respiratory function tests were performed in 110 workers who were occupationally exposed to asbestos-cement dust in the period from 7 to 34 years. Due to the results obtained, the following groups of patients were analysed according to years of asbestos-cement exposure and the habit of cigarette smoking. The analysis of the years of exposure to asbestos-cement dust revealed that the workers with the exposure longer than 16 years had significantly lower FVC and FEV1 (P less than 0.001) than the workers whose exposure was less than 16 years. In view of increasing age this deterioration proved to be significantly higher than it had been expected. Of all the subjects included in this study 7% of them were found to have a partial respiratory insufficiency. The phenomenon could not be explained either by the length of exposure or by the habit of cigarette smoking. In the smoking subjects with the longest exposure, a markedly lower SaHbO2 was found as compared to the smokers with the shortest exposure (P less than 0.05).

Adult↗