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Biomedical subjects

B Kaye

Publications and source records attributed to B Kaye.

30 records · Page 2Linked to original sources
PubMed1977

Uptake of [14C]oxamniquine by Schistosoma mansoni.

The uptake and retention of drug-related material by Schistosoma mansoni was studied in the mouse host following a single oral or intramuscular dose (50 mg/kg) of [14C]oxamniquine. Male worms took up more labelled material than did female worms but the amount in each particular sex of worm was found to be similar after both routes of administration. Exposure of worms was therefore independent of the route of administration. Six days after drug administration, at the time of an hepatic shift, significantly more drug-related material was present in male worms than in female worms. Examination of worms recovered from mice 4 h after treatment showed that metabolites of oxamniquine constituted 70--90% of the drug-related material present in the worms. Both sexes of worms were able to take up metabolites of oxamniquine in vitro.

Administration, Oral↗
PubMed1976

The metabolism of oxamniquine - a new schistosomicide.

The metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, has been studied in the mouse, rat, hamster, rabbit, rhesus monkey, dog and man. Urinary excretion is a major route of elimination in man. The compound is converted to two metabolites, the major one arising from oxidation of the 6-hydroxymethyl group to a carboxyl group and the other by oxidation of the side chain to give the 2-carboxylic acid. There is a species at the dose levels used since both acidic metabolites were found in appreciable quantities only in the urine of mouse, rabbit, hamster and dog. The 2-carboxylic acid was not found in the urine of rhesus monkey and rat and occurred in only trace amounts in human urine.

Animals↗
PubMedDate not supplied

The prevalence and nature of back pain in an industrial complex: a questionnaire and radiographic and HLA analysis.

A questionnaire relating to presence and nature of back pain was distributed to all 10,150 employees (59% men) of an industrial complex. The questionnaire was returned by 2892 subjects (65% men). Of these, 1880 (65% of responders or 19% of total) reported a history of back pain. One hundred twenty-four described their back pain as insidious in onset, persisting for at least three months, developing at less than 40 years of age, being associated with morning stiffness, and showing improvement with exercise. Three hundred sixty-seven subjects scored four of these five features. Pelvic radiographs of 342 persons were available for blind evaluation. Sixteen patients (12 men) were shown to have definite ankylosing spondylitis (Grade III or IV sacroiliitis or HLA B27-associated Grade II sacroiliitis). Only one of these persons was known to have spondylitis. The majority of these symptomatic patients had been seen by both medical and nonmedical practitioners.

Adolescent↗
PubMedDate not supplied

The cure for lazy eye.

The use of the term lazy eye blurs the distinction between amblyopia and strabismus, often causing parents to confuse the two problems. Parents often infer a causal explanation from the descriptive term, lazy eye. This misunderstanding causes parents to believe the child may outgrow the disorder. Therefore, an opportunity for early treatment during the important formative years may be lost. The correctly informed and knowledgeable parent will be more active and responsible in making sure that the child, especially the noncompliant child, follows the advised treatment.

Amblyopia↗