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Biomedical subjects

B Kelly

Publications and source records attributed to B Kelly.

At least 19 recordsLinked to original sources
PubMed1992

Developmental expression of major myelin protein genes in the CNS of X-linked hypomyelinating mutant rumpshaker.

Rumpshaker (rsh) is an X-linked mutation causing hypomyelination of the CNS of mice and has recently been identified as an allele of jimpy (jp). The mutation (known as jprsh) differs in several respects from other X-linked myelin mutants, including jp, in that mice have normal longevity, oligodendrocyte numbers are not decreased, and cell death is not a feature. Myelin sheaths are deficient in immunostainable PLP protein. The present study examines the developmental expression of the major myelin protein genes and translatability of PLP and MBP mRNA. Differences between the spinal cord and brain of mutants are evident in that mRNA levels are more markedly decreased in the brain. Protein levels are severely reduced in both locations and to a proportionately greater extent than the mRNA, particularly in the spinal cord where PLP RNA and protein are approximately 80% and 10-20%, respectively, of age-matched wild type mice. DM-20 protein, the other major product of the PLP gene, is disproportionately expressed in rumpshaker as is a 10 kDa proteolipid. In vitro translation studies indicate a marked decrease in PLP translation products from mutant RNA. There is no deficiency in the number of PLP mRNA-expressing oligodendrocytes although the abundance per cell is reduced. The data suggest that the phenotypic effects of the mutation may be associated with reduced translation of major myelin proteins, in particular PLP and its incorporation into compact myelin. However, the mutation is compatible with survival of oligodendrocytes and their differentiation to the stage of expressing PLP/DM-20 mRNA.

Aging↗
PubMed1992

Story processing in right-hemisphere brain-damaged patients.

The understanding of stories requires sensitivity to structural aspects of narrative, the emotional content conveyed by the narrative, and the interaction between structural and emotional facets of the story. Right-hemisphere-damaged (RHD) and normal control subjects performed a number of different analytic tasks which probed their competence at story comprehension. Results revealed that RHD subjects perform at a level comparable to that of normal controls with stories that follow a canonical form and that they show few difficulties with structural aspects of narrative. Contrary to expectation, they are strongly influenced by the "interest" level of a story and by other factors that tap emotional sensitivity. Findings are discussed in terms of the processing and arousal mechanisms which may give rise to the observed pattern of difficulties in RHD patients.

Aged↗
PubMed1992

Professional ethics as perceived by American nursing undergraduates.

The purpose of the study was to explore the perceptions of American nursing undergraduates about professional ethics. The method was qualitative; specifically, a grounded theory approach was used. The sample comprised 23 senior baccalaureate nursing students, from a possible population of 120, who were in their final clinical rotation prior to graduation. Informants were volunteers who gave informed consent having been briefed on the purposes of the study and how their confidentiality would be protected. Data were collected through audio-taped interviews and clinical logs. Analysis was conducted through the constant comparative method. Findings revealed two concepts central to their view of good nursing. These were: (a) respect, and (b) caring. Respect was described as respect for patients and families, respect for self, colleagues and the profession. Caring was associated with showing 'concern and love', providing psychological support, getting involved, being 'cheerful and friendly' and 'taking the time' to do a good job. They did not evidence an ambiguous professional role. They espoused values consistent with the professional code of ethics. They perceived that respect for others was basic to good nursing. They believed that good nurses cared about their patients and how nursing was done. They appeared to link professionalism with good nursing.

Adult↗
PubMed1992

The professional self-concepts of nursing undergraduates and their perceptions of influential forces.

This article explores the professional self-concepts of senior nursing undergraduates and their perceptions of the most significant forces that influenced the process. The method was qualitative; a grounded theory approach was used. The sample included 23 senior baccalaureate nursing students in their final clinical rotation prior to graduation. Audiotaped interviews were analyzed through the constant comparative method. Informants overwhelmingly perceived themselves as caring. They valued professional competence and many identified a lack of confidence in their skills. Caring qualities, caring role models, and qualities of the role models are listed.

Attitude of Health Personnel↗
PubMed1991

The professional values of English nursing undergraduates.

The purpose of the study was to examine and describe what English nursing undergraduates internalize as professional values. The method was qualitative; specifically, a grounded theory approach was used. The sample comprised 12 senior baccalaureate nursing students from two educational institutions in the north of England. Informants were volunteers who gave informed consent having been briefed on the purposes of the study and how their confidentiality would be protected. Data were collected through audio-taped interviews and the constant comparative method was used to analyse data. The findings revealed that informants perceived two concepts as central to their professional values. These were respect for patients and 'caring about the little things'. They valued the rights of patients to be treated with respect, to know what was happening to them and to have a say in what happened to them. They described the 'little things' as 'an approach with patients that gets through to them'; 'getting out the mirror so they can see themselves'; 'fixing their water so they can reach it'; worrying about someone's dentures or the cat they left at home. They expected that their values would be in conflict with common hospital practice. They valued 'fitting in' and 'going along' but retained their own ideas and values until such time as these could be implemented. They perceived themselves as powerless to create change as new graduates. They believed the overwhelming power resided in the hospital system and the ward sister/charge nurse. They were not inclined toward a career in hospital nursing.

Attitude↗
PubMed1991

Relationships between mental adjustment to HIV diagnosis, psychological morbidity and sexual behaviour.

This paper examines patterns of psychological adjustment in a small sample of asymptomatic HIV antibody positive men. Comparison is made with data available on male cancer patients. HIV positive men reported greater degrees of anxious preoccupation and hopelessness, and lower levels of the more adaptive 'fighting spirit' response. In HIV-infected men, depression correlated positively with frequency of high risk sexual practices.

Adaptation, Psychological↗
PubMed1991

Effect of otitis media on infrared tympanic thermometry.

This study was designed to determine if temperature readings using a new tympanic thermometer are affected by otitis media. These readings were also compared to a rectal or oral temperature. Eighty-four children with unilateral suppurative or non-suppurative otitis media diagnosed clinically by their pediatricians were enrolled in the study. Temperatures were measured in both ears using the Thermoscan PRO-1 Instant Thermometer and rectally or orally by a glass or electronic predictive thermometer. For 67 children with unilateral suppurative otitis media the mean temperature in infected ears was 0.38 degrees Fahrenheit higher than in uninfected ears (p = .005). Neither temperatures measured in affected nor those from unaffected ears differed significantly from oral or rectal control readings. For 17 children with unilateral non-suppurative otitis media there was no statistically significant difference between temperatures in affected and unaffected ears or between the temperatures in either ear and the oral or rectal control. Our data show that temperatures taken in ears with suppurative otitis media are slightly higher than those in normal ears. This difference is of minimal clinical significance and does not affect the accuracy when compared to oral or rectal control readings.

Body Temperature↗
PubMed1991

Responses of children, parents, and nurses to tympanic thermometry in the pediatric office.

This study was designed to assess children's behavioral responses to tympanic thermometry. In addition, parents' and nurses' impressions of this new technology were evaluated. 224 patients were enrolled from three private pediatric practices. Patients were alternately assigned to have their temperature taken with either a tympanic thermometer or with a rectal or oral thermometer. Parents and nurses were then asked to fill out a short questionnaire to describe their observations of the child's behavior during temperature taking and to describe their own feelings about the temperature taking method used. Parents were also asked to assess their usual method of temperature taking at home and their child's usual behavioral response. Tympanic thermometry was rated higher by both parents and nurses for speed, ease, cleanliness, and safety. Parents and nurses were more confident in the accuracy of traditional temperature taking methods. Children whose temperatures were taken rectally were more likely to be observed by both parents (p = .02) and nurses (p = .01) to have a negative behavioral reaction to the procedure than children whose temperatures were taken by tympanic thermometry. There was no difference observed between the behavioral responses of children who had temperatures taken orally and those who had tympanic thermometry.

Adolescent↗
PubMed1991

Cost effectiveness of tympanic thermometry in the pediatric office setting.

This study was designed to see if tympanic thermometry might be more cost effective than cheaper more traditional methods of thermometry when office staff time saved is taken into account. There were 224 patients enrolled from three private pediatric practices. Patients were alternately assigned to have their temperature taken with either a tympanic thermometer or with a rectal or oral thermometer depending on the patient's age. For each child enrolled in the study a nurse was asked to time the temperature taking process. Items included in the cost analysis: a) thermometer costs; b) disposable supply costs; c) personnel costs; d) equipment service costs. The mean duration of temperature taking was 35.2 seconds using tympanic thermometers, 73.4 seconds using electronic predictive thermometers, and 247.2 seconds using glass thermometers. In practices taking an average of 10 temperatures per day, tympanic thermometry saved $2,316/year when compared to glass thermometers and $442/year when compared to electronic predictive thermometers. The data presented in this study show that when nursing time is taken into account, tympanic thermometry is less expensive to perform than traditional methods of thermometry despite the initial higher cost of the thermometer.

Body Temperature↗
PubMed1991

The evaluation of teaching in undergraduate psychiatric education: students' attitudes to psychiatry and the evaluation of clinical competency.

There is an increasing demand for improved skills by medical graduates in the psychosocial aspects of medical care. Psychiatrists as educators need to play an important role in the development and evaluation of education in many areas of the undergraduate curriculum in addition to the continuing education of graduates. In this review approaches to the evaluation of undergraduate psychiatric education are discussed with particular emphasis on students' attitudes to psychiatry. Key issues that remain to be addressed include the clarification of the most appropriate goals for undergraduate education in psychiatry, the most valid means of evaluating such educational programmes, particularly clinical competency and, finally, the many tasks in improving the status of the psychosocial aspects of medical care for students and their clinical teachers.

Attitude of Health Personnel↗
PubMed1991

Job satisfaction among British and American hospital staff nurses.

The basic research design was descriptive, correlational, and non-experimental. Sampling was nonprobability; a convenience sample was obtained after subjects gave informed consent. A Likert-type attitude scale was used to collect data on job satisfaction. The population was full-time hospital staff nurses and a total sample of 146 participated in the project. The settings were four hospitals, two in the north of England and two in the midwest United States. The British study was done three years after the American. Data were collected by questionnaire, which was distributed by hand and collected personally. Results revealed British nurses were very dissatisfied with pay. If it were not for the pay component, the British nurses would have scored significantly higher than Americans on overall satisfaction. American nurses perceived greater satisfaction with their nursing colleagues than the British but were less satisfied with administration. However, British nurses perceived a more cooperative relationship with physicians. British nurses, despite their complete dissatisfaction with pay, would overwhelmingly choose nursing again.

Attitude of Health Personnel↗
PubMed1990

The use of biomarkers in the prediction of survival in patients with pulmonary carcinoma.

Data on ten variables and 16 biomarkers were obtained on 119 patients with newly diagnosed pulmonary cancer. The prognostic value of 16 biomarkers (alpha-1-antitrypsin [AAT], adrenocorticotropic hormone [ACTH], alpha-fetoprotein [AFP], carcinoembryonic antigen [CEA], human chorionic gonadotropin [HCG], immune complexes, immunoglobulins, N-terminal peptide of proopiomelanocortin [NTERM], and tumor-associated antibody [TAA]) was tested by adding these to the model of age, gender, stage, morphology, Feinstein's classification of symptoms, Karnofsky scale, leukocyte count, recent weight loss, and liver enzymes. Using Cox's regression method and a forward stepwise procedure, seven biomarkers (ACTH, AAT, AFP, calcitonin, HCG, TAA, and prolactin) entered the model. Elevated levels of cortisol and TAA were associated with longer survival. The selection of biomarkers by stepwise regression needs to be interpreted with caution, especially since the Z scores were found to be dependent on the particular variables included in the model. Furthermore, when dichotomized on maximum of the normal laboratory values, HCG and AFP were infrequently (2%) elevated. The lack of correlation among the biomarkers supports the hypothesis of random derepression of the genome of cancer cells. Further studies in improved modeling and the formulation of a biomarker index could enhance our understanding of the biology of cancer.

Adenocarcinoma↗
PubMed1990

Student error patterns as a function of curriculum design: teaching fractions to remedial high school students and high school students with learning disabilities.

This study evaluated the relative effectiveness of a curriculum that incorporated three empirically derived principles of curriculum design with a basal approach in teaching basic fractions concepts to students with learning disabilities and other low performing students in high school remedial math classes. The components of effective mathematics instruction articulated by Good and Grouws (1979) were implemented in both conditions. Thus, the curriculum design variables were isolated by keeping all other aspects of instruction constant. Results indicated that, although both programs were reasonably successful in teaching the material, the curriculum program utilizing sophisticated principles of curriculum design was significantly more effective. Mean scores on a curriculum-referenced test were 96.5% for that group and 82.3% for the basal group. Secondary analyses of item clusters revealed that areas of weakness in the performance of the basal group could be directly linked to hypothesized flaws in its curriculum design.

Adolescent↗
PubMed1990

The impact of parental loss on adolescents' psychosocial characteristics.

This study examined ten measures of personality, self-image, and emotional and family problems in a sample of 2,158 Australian adolescents, some of whom had suffered parental loss. The data reveal a pattern of poorer adjustment in adolescents who have lost a parent, but clearly demonstrate that type of loss and family reconstitution have no differential effects on psychosocial development. Implications for future research are discussed.

Achievement↗