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Biomedical subjects

B Kiersnowska-Rogowska

Publications and source records attributed to B Kiersnowska-Rogowska.

12 recordsLinked to original sources
PubMed1979

The effect of O-betahydroxyethyl-rutosides (HR) on the number of platelet-leukocyte aggregates in patients with occlusive arterial disease.

The diagnostic value and the effect of the therapy on the number and kind of platelet-leukocyte aggregates in 68 patients with arteriosclerosis obliterans of the lower limbs were investigated. The modified SILBERGLEIT'S method was used. 8 types of aggregates were found. The means number of aggregates in 20 healthy subjects was 8.2 but in 46 patients suffering from obliterative arteriosclerosis of the lower limbs this number was significantly higher, i.e. about 62. A significant decrease in the number of platelet-leukocyte aggregates in the group of 14 patients receiving HR orally 1800 mg daily and 16 patients receiving HR intravenously 2000 mg daily was found. In 16 persons a lower HR dose (orally 900 mg daily and intravenously 500 mg daily) did not influence the number of rosettes. In 22 patients receiving nicotinic acid (orally 900 mg daily, intramuscularly 600 mg daily) no significant changes in the number of rosettes was observed.

Administration, Oral↗
PubMed1978

N-acetyl-neuraminic acid (NANA) serum level in the diagnostics of preleukemic states, acute micromyeloblastic leukemias and pancytopenias.

The levels of N-acetyl-neuraminic acid were determined in patients with preleukemic states, acute micromyeloblastic leukemias and pancytopenias. A statistically significant increase of NANA was found in patients with micromyeloblastic leukemia in comparison with preleukemic states and pancytopenias. A significant rise in the NANA level was observed in preleukemic states in comparison with pancytopenia of other origins. The assay of the NANA level may be employed as a sensitive biochemical test for differential diagnostics of these diseases.

Diagnosis, Differential↗
PubMed1976

The influence of azathioprine on the behaviour of blood platelets in vitro.

The influence of azathioprine on human platelets was studied in vitro. Azathioprine in a final concentration of 10(-4) M caused significant inhibition of spontaneous sedimentation and aggregation of platelets, but did not effect platelet adhesiveness or resistance to freezing and thawing. The influence of azathioprine is probably due to thioimidazole, this last being a potent stimulating agent of phosphodiesterase activity, involved in the metabolism of cyclic AMP to 5' AMP. These observations indicate that the widely used platelet function assays could be influenced by drugs. The current therapy should therefore be taken into account when the results of the tests are evaluated for clinical purposes.

Azathioprine↗
PubMed1976

The influence of lymphocytes on blood proteins in vitro.

Autologous IgG, IgM and IgA globulins were assayed quantitatively by the immunodiffusion method in cultures of white blood cells from 14 patients with chronic lymphocytic leukemia. In cases in which levels of IgG in the patient's blood were lower than 1,000 mg/100 ml, the IgG globulin was statistically significantly deficient in the cultures. Moreover, concentrations of IgG in the culture supernatant and absolute lymphocytosis were moderately strongly correlated. These observations indicate that the white blood cells of leukemia patients combine with IgG in their environment, and that this may be one of the mechanisms leading to hypogammaglobulinemia.

Agammaglobulinemia↗