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Biomedical subjects

B Knobel

Publications and source records attributed to B Knobel.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Preoperative diagnosis of carcinoid of the terminal ileum in the absence of carcinoid syndrome].

Carcinoid of the small intestine, usually found in the terminal ileum, presents a diagnostic challenge when the classic clinical and laboratory findings are absent. The commonest symptom, marked abdominal pain due to intussusception, may arouse suspicion of carcinoid. The precise preoperative diagnosis in the absence of the classic syndrome is impossible and the only way to diagnose it is by colonoscopic biopsy of the terminal ileum. The case described illustrates such a preoperative diagnosis in a 59-year-old woman with severe abdominal pain, nausea, vomiting and weight loss. X-ray studies aroused suspicion of tumor intussusception as the cause of the intestinal obstruction. Colonoscopic biopsy revealed the presence of a carcinoid tumor. However, there had been no symptoms of the carcinoid syndrome, nor was there increased urinary 5-hydroxy indoleacetic acid. On operation the tumor was found to be disseminated and unresectable, so surgical intervention was limited to palliative ileo-transversostomy.

Biopsy↗
PubMed1987

Multifocal contact dermatitis to nitroderm TTS 5 with extensive postinflammatory hypermelanosis.

Allergic contact dermatitis to nitroglycerin has been previously reported. A localized cutaneous burn-like reaction due to the transdermal device was recently described. We are presenting a case of recurrent allergic contact dermatitis due to nitroglycerin as well as to its delivery device, resulting in numerous patches of postinflammatory hypermelanosis at the sites of application.

Administration, Cutaneous↗
PubMed1985

Coexistence of nonsecreting and nonproducing light chain multiple myeloma.

A 61-year-old female patient presented with osteolytic skeletal lesions. Open rib biopsy disclosed tumor tissue which consisted of two types of cells: massive infiltrates of poorly differentiated lymphoplasmacytic cells were surrounded by large deposits of differentiated plasma cells. Serum immunoglobulins were normal. No light chains could be found in the urine. An immunoperoxidase technique was employed to detect intracellular immunoglobulins. While the partially differentiated cells were negative, the plasma cells were stained strongly positive for kappa light chains.

Female↗
PubMed1985

Intestinal Buerger's disease.

We describe a 50-year-old man who, at 26 years of age, underwent a hemicolectomy on the right side of the abdomen due to infarction of the right colon. At 35 years of age, a stenotic, ischemic segment of distal jejunum was resected. Later he had had intermittent claudication, migratory thrombophlebitis, and recurrent cerebral infarctions. The mesenteric and mural blood vessels of both resected specimens of bowel showed an occlusive process with organized and recent thrombi and marked transmural inflammation. The internal elastic lamina and media in the arteries were preserved and there was no evidence of atheroma or calcification. The histologic findings were consistent with thromboangiitis obliterans. We suggest that the same mechanism may be responsible for intestinal peripheral and cerebrovascular involvement.

Colon↗
PubMed1984

Influence of systemic administrated beta-blockers on tear secretion.

The secretion of tears was evaluated by the Schirmer test in 96 patients and 66 controls. This article reports on the pharmacologic and not the immunologic effects of adrenergic beta-blockers on tear flow. The facilitation of lacrimal flow depends not only on the parasympathetic nerves but also on the beta adrenergic nerves. We found that the unselective adrenergic antagonist, propranolol, decreased the tear flow while, oxprenolol because of its intrinsic sympathomimetic activity, did not decrease significantly lacrimal secretion.

Adrenergic beta-Antagonists↗
PubMed1984

Sheehan's syndrome and empty sella turcica.

A 54-year-old woman presented with clinical and laboratory features of gonadal, adrenal and thyroid deficiency. Endocrinological investigation showed anterior pituitary failure, which was probably a result of panhypopituitarism following blood loss during childbirth 26 years previously. Sheehan's syndrome was diagnosed. Computerized tomography of the skull revealed an empty sella. We suggest that pituitary necrosis and involution allow penetration of cerebrospinal fluid to the sellar cavity through a defect in the diaphragm sella, causing formation of an empty sella.

Adrenocorticotropic Hormone↗
PubMed1984

Peripartum cardiomyopathy.

A 26-year-old woman developed severe postpartum cardiomyopathy in early puerperium. Ligation of the inferior vena cava prevented recurrent pulmonary embolism but did not affect her hemodynamic condition, which deteriorated constantly. During continuous hemodynamic monitoring only vigorous volume replacement with an increase of the left ventricular filling pressure to 32 mm Hg improved cardiac output significantly. The presence of a high titer of antiactin antibodies 9 months after the delivery supports the theory that the peripartum cardiomyopathy was of autoimmune etiology.

Actins↗
PubMed1981

Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.

Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone). Their occurrence after low doses of the drug, and subsequent investigation, revealed the presence of hemoglobin Hasharon, and low content of NADH-dependent methemoglobin reductase in five members of an East European ashkenazic Jewish family.

Adult↗