Biomedical subjects

B Kobal

Publications and source records attributed to B Kobal.

4 recordsLinked to original sources

PubMed2004

[Current surgical management in ovarian cancer recurrences].

Ovarian cancer is a tumor with a high trend of recurrence and this occurrence consistently increases the difficulty of the patient cure and reduces the efficacy of current treatments. The role of surgery in persistent or recurrent ovarian cancer is controversial and the type of surgery can be different according to the different stages and invasion of tumor; it can be a debulking surgery followed by chemotherapy (to eradicate the most part of ovarian cancer, leaving a minimal tumoral residue), an interval surgery (for advanced ovarian cancer stage in previously operated patients, followed by 2 or 3 inductive chemotherapy cycles and subsequently a cytoreductive redo surgery) and a cytoreductive secondary surgery, after optimal primary surgical treatment and minimal tumoral recurrence. In some cases it is possible either to perform a debulking surgery during a primary (after the conclusion of primary treatment) or a salvage or palliative surgery (to improve, after an acceptable time period, clinical symptoms in patients with progressive cancer or resistant to treatments). The aims of surgical therapy, to be performed in a patient with ovarian cancer relapse, are to reduce, as much as possible, the tumour size, to increase the quality of life and to increase the survival time; in this review different surgical techniques to be carried out in each case, selected for disease staging, for tumour cells kinetic and for surgical goals, are discussed.

Carcinoma↗

PubMed1999

Herpes simplex genitalis type 2: our experiences.

OBJECTIVE: To review the recent research in genital HSV infection and to pay attention to this problem in Slovene population. METHODS: Review of all papers in the field on Medline 1994-98. A descriptive retrospective analysis of symptoms, seroprevalence, treatment, complications and follow-up of 49 HSV-1 and HSV-2 seropositive patients. RESULTS: Five patients with overt genital herpes were HSV-1 seropositive, and four were HSV-1 and HSV-2 seropositive. One patient had extragenital spread and HSV proctitis. Treatment consisted of 1 gr daily dose of Acyclovir (ACV) in combination with topical ACV for two to three weeks. Recurrences were intermittently treated in three patients and one started suppressive treatment. Three pregnancies terminated vaginally with healthy babies. CONCLUSIONS: According to literature overview and our experiences, more attention should be paid on revealing mild forms of genital herpes in order to diminish the spread of infection and its consequences.

Acyclovir↗

PubMedDate not supplied

[Characteristics of patients with laparoscopically verified pelvic inflammation].

Comparing the characteristics of the two groups young women: one with laparoscopically confirmed pelvic inflammatory disease (PID) and the other with no PID (control group) but corresponding to the first group by age, marital status and number of pregnancies, it has been found that the patients with PID are below 25 years of age, have a lower degree of education (p less than 0.05), and 25.5% of them do not use any contraceptive method (p less than 0.01). It has also been observed that in their gynecologic history they mention an episode of lower abdominal pain (p less than 0.01). A further comparison of this finding with laparoscopically confirmed adnexal changes has shown that in 50% of the study group patients there exist sequelae of an earlier PID episode (asymptomatic salpingitis). The results obtained point to the need for carefully connecting the characteristics of the population regarding the risk of PID and the minimal clinical symptoms in diagnosing PID.

Abortion, Spontaneous↗

PubMedDate not supplied

Laparoscopic treatment of acute adnexitis; one step forward.

Supplementary laparoscopic method accompanying antibiotic treatment in 8 patients with acute PID (ALT Group) was compared to the group of 28 patients with acute PID, diagnosed laparoscopically and treated medically (MLT Group). Rapid subjective improvement of general status in which main symptoms of acute PID disappeared, the absence of early PID complications (p less than 0.01), shorter hospital treatment (p less than 0.05) and the absence of recurrence (p less than 0.01) in the first 6 months are the major advantages of the supplementary laparoscopic treatment of acute adnexitis found in preliminary results of the present study. It seems that supplementary laparoscopic procedures might be more efficient than medical treatment alone.

Acute Disease↗