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B Kowalski

Publications and source records attributed to B Kowalski.

6 recordsLinked to original sources
PubMed1979

Intake of volatile nitrosamines from consumption of alcohols.

Volatile nitrosamines were determined in alcoholic drinks during epidemiologic studies on the relationship between esophageal cancer incidence and alcohol consumption in Normandy, France. Nitrosodimethylamine (NDMA) was found commonly in most alcoholic drinks tested, with the exception of wine. The average level, about 2 micrograms/liter in beers, was higher than that for other drinks; the range was 0.2--8.6 micrograms/liter. Traces of nitrosodiethylamine (NDEA) were also detected in spirits and ciders. No significant increases in levels were found after nitrosation. Calculation of daily intake in the study region showed that the main intake of volatile nitrosamine is from NDMA in beer. The intake of NDEA through consumption of cider is about one-third that of NDMA from all sources.

Alcoholic Beverages↗
PubMed1978

Absorption, tissue deposition and passage into eggs of N-nitrosodimethylamine in hens.

The experiments were performed on 262 laying hens divided into 8 groups: 5 groups of hens were given orally N-nitrosodimethylamine (NDMA) in single doses of 30, 10, 3, 1 and 0.1 mg/kg of body weight, two groups received tap water containing 2 and 5 mg NDMA/kg, provided ad libitum for 20 consecutive days, and one group of layers served as a control. Birds were selected at random and sacrificed at one or two day intervals and NDMA content was determined in blood, muscles, liver, brain and in collected eggs. The highest concentrations of NDMA were found 24-36 hours after dosing in all investigated tissues and eggs. A single oral dose of 0.1 mg NDMA/kg produced tissue levels up to 0.06 mg/kg and resulted in excretion of detectable amounts of the carcinogen in eggs for up to 6 days. After large doses, 10 mg and 30 mg NDMA/kg, concentrations in corresponding tissues reached 6.0 and 12.7 mg/kg, and the presence of NDMA in eggs could still be detected after 12 and 14 days. Birds receiving NDMA in drinking water showed increasing NDMA concentrations in all analysed tissue and eggs. After 12 days, the highest levels were found in eggs, blood and brain. Practical implications of the results must be evaluated from the point of view of human safety.

Animals↗