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Biomedical subjects

B Krause

Publications and source records attributed to B Krause.

At least 19 recordsLinked to original sources
PubMed1992

Naloxone stimulation test in women with hypothalamic amenorrhea: a preliminary report.

We researched the possibility of the induction of ovulation by means of chronic opioid receptor blockade in 4 women with hypothalamic amenorrhea. Daily 4 mg naloxone were given as a bolus injection intravenously. By means of continuous determination of LH, FSH, 17-beta-estradiol (E2) and progesterone as well as of sonographic folliculometry follicular growth and subsequent ovulation should have been proved. Neither we found alterations of the basal values of LH, FSH, E2 and progesterone, nor we observed a follicular growth. These results lead us to the conclusion to put a naloxone stimulation test before further therapy. In this way opioid mediated hypothalamic ovarian insufficiencies can be registered and a therapy optimum can be reached early.

Adult↗
PubMed1991

[Possibility of ovulation induction using naloxone in women with hypothalamic amenorrhea].

Within the study we treated 6 women suffering from hypothalamic amenorrhea with 4 mg naloxone intravenous daily. The duration of the study was at most 30 days. The estimation of hormonal baseline and changes occurs daily, furthermore everyday sonographic folliculometry. In 2 patients the chronic opiate receptor blockade leads to a drastic stimulation of gonadotropin secretion. One of these women (responder in Naloxone-Test) has a long standing elevation of LH and FSH resulting in an ovulation 2 days past end of the therapy. The other women (non-responder in Naloxone-Test) reaches a follicular growth till 17 mm follicle diameter following in preterm atresia during therapy. In another woman (minimal-responder in Naloxone-Test) occurs a short and weak elevation of gonadotropins without any basic stimulation of the hypothalamic-pituitary-ovary axis. The results of this study show that: 1. it's possible to discern an opioid mediated hypothalamic amenorrhea and 2. a Naloxone-Test or Naloxone-Stimulation-Test should be put before starting a therapy with opiate antagonists in hypothalamic amenorrhea.

Adult↗
PubMed1990

[Dopamine antagonists in anovulation?].

Increased hypothalamic dopamine turnover may prevent the ovulatory LH peak by different mechanisms and may in this way result in anovulation. Ten patients with anovulatory menstrual cycles who had been treated with clomiphene citrate without success were given the dopaminolytic drug pimozide (Antalon) at a dose of 5 mg/day orally either from day 7 to day 11 (7 women; group 1) or from day 11 to day 15 of the menstrual cycle (4 women; group 2). One patient from group 2 ovulated during the treatment cycle. A further woman from this group exhibited an LH peak, but did not ovulate, whereas a slow increase of the circulating LH level was recorded in the remaining two patients. Systematic investigations should clarify whether introduction of dopaminolytic therapy in the treatment of hypothalamic anovulation may be justified.

Anovulation↗
PubMed1990

[Menstrual cycle, opioids and hypothalamic amenorrhea: from physiology to pathology].

The central part of menstrual cyclicity is the arcuate nucleus within the mediobasal hypothalamus, which is shown to be the origin of GnRH. This neuronal oscillator is influenced by many endogenous substances and its periodically activity is modulated by them. The endogenous opioids are such substances. They are widely distributed within the organism and are endogenous ligands of opiate receptors. The endogenous opioids participate in many somatic functions such as regulation of ovarian cyclicity. Furthermore they are causal involved in hypothalamic amenorrhea.

Amenorrhea↗
PubMed1990

[Ovulation induction using clomiphene conversion].

20 anovulatory and clomiphene resistant patients had been treated by the so called clomiphene conversion. Pregnancies could be achieved in 6 women. 7 further patients reacted by ovulation. In selected cases the clomiphene conversion may be an alternative of therapy with gonadotrophins and GnRH pulsatile.

Adolescent↗
PubMed1989

[The influence of endogenous opioids in hypothalamic amenorrhea. Diagnostic and therapeutic aspects].

We investigated the possibility of induction of ovulation by means of chronic opioid receptor blockade with naloxone. Daily 4 mg were given as an intravenous bolus injection in 4 women suffering from hypothalamic amenorrhea till the 30th day of therapy. A possible maturation of ovarian follicles and a subsequent ovulation should be proved by means of daily determination of LH, FSH, estradiol and progesterone as well as of a sonographic folliculometry. The day prior to and the first day of naloxone treatment we took blood samples every 10 minutes during 4 hours for determination of LH pulse frequency and amplitude. Neither we found any alteration of the basal values of LH, FSH and estradiol, nor we observed a follicular growth. These results lead us to the conclusion to introduce a naloxone stimulation test as a further diagnostic step. In this way opioid mediated hypothalamic ovarian insufficiencies could be registered and a sufficient therapy could be reached.

Amenorrhea↗
PubMed1989

[Artificial respiration at home--an exceptional form of intensive care].

A couple with a child suffering from transverse lesion of the spinal cord with respiratory paralysis were greatly interested in taking care of him at home. After making technical and organisational preparations we transferred the child to his home with a respiratory machine. The child has now been at home for 3 years. Although the successful course of this home respirator treatment shows the correctness of our decision, we look upon such a procedure as an exception.

Child↗
PubMed1986

Serum bactericidal activity of two newer quinolones against Salmonella typhi compared with standard therapeutic regimens.

The bactericidal activity of two newer quinolones, ciprofloxacin and ofloxacin, against eight strains of Salmonella typhi was examined by the serum dilution test and studies of bacterial killing kinetics in human serum, and compared to standard regimens. Bactericidal titers for ciprofloxacin ranged from 1:388 to 1:119 two hours and from 1:119 to 1:57 six hours after volunteers received an oral dose of 500 mg. The respective titers obtained after a 200 mg oral dose of ofloxacin were somewhat lower, but still exceeded 1:16 in all instances. Studies of bacterial killing kinetics demonstrated a rapid bactericidal action of both drugs against all strains tested. Compared to the classical anti-typhoid agents chloramphenicol, cotrimoxazole and amoxicillin, the new quinolones showed both markedly higher bactericidal titers and more rapid killing of Salmonella typhi in human serum.

Adult↗
PubMed1985

[Resolution capacity in intra-arterial digital subtraction angiography of the A. carotis].

Intraarterial digital subtraction angiography of the intracranial vascular system is increasingly one of the more important advances in neuroradiology. The paramount disadvantage is less spatial resolution. Based on experimental and theoretical studies recommendations are given to reach a optimum of spatial resolution: Selective intraarterial application of undiluted contrast medium (300 mgJ/ml); volume: 3 ml in a. carotis comm.; flow: 5 ml/sec.

Carotid Artery, Internal↗
PubMed1985

[Endoscopic percutaneous gastrostomy--a simple technic for long-term nutrition].

A simple procedure: 'Percutaneous endoscopic gastrostomy' was useful to provide seriously ill patients with a long-term enteral nutritional support. The catheter remained in place for 26 days in median, up to 1 year. No complications were related to the puncture of stomach. One leakage after changing the catheter through a narrowed channel had to be treated surgically.

Adolescent↗