Biomedical subjects

B Krosse

Publications and source records attributed to B Krosse.

23 records · Page 2Linked to original sources

PubMed1983

[Sporadic occurrence of benign myopathy with early contractures (Emery, Dreifuss and Rotthauwe)].

A myopathy which sporadically appeared in a young male corresponds clinically, electromyographically, histologically and cardiologically to the rare picture of the X-chromosomally recessive benign myopathy with early contractures. The coordination to the clinical picture mentioned and the genetic advice, taking into consideration the X-chromosomally recessive heredity, are discussed and proved.

Adult↗

PubMed1983

[Effect of obesity on cardiovascular performance].

On 55 healthy test persons with normal weight and 76 healthy middle-aged obese test persons the measurement of systolic time intervals was performed standing and lying. In 39 obese patients and 55 test persons with normal weight a load ergometry was carried out. No significant difference between persons with normal weight and extreme overweight was recognized with regard to the index of tension. However, there were clear differences between persons with normal and overweight as to the time of tension and left-ventricular ejection time lying and standing, independent of the behaviour of blood pressure. In persons with overweight a significantly lower cardiac output was found. The index of tension of obese persons with a degree of efficacy below 75 Watt was on an average 1.04. Only half of the persons with overweight reached a degree of efficacy of 100 Watt. In 32 obese persons with a degree of efficacy of more than 75 Watt the regulation of frequency and blood pressure did not differ from that of persons with normal weight.

Adult↗

PubMed1982

[Treatment of ventricular arrhythmias with mexiletine].

The development of new antiarrhythmic drugs allows to a certain extent the performance of a differential therapy and prophylaxis. This also concerns the lidocaine-like substance mexiletine, which according to Vaughan-Williams is to be classified into class I B of the antiarrhythmic drugs with direct membrane effect. It is effective in disturbances of the ventricular rhythm also in oral therapy, which in most cases are more life-endangering than the supraventricular ones. In own examination in 21 of 26 patients a complete or far-reaching suppression of accumulated extrasystoles and particularly of ventricular tachycardias could be achieved by an oral long-term therapy with 600--800 mg mexiletine. In the acute experiment short-term infusions were not effective in patients with ventricular tachycardias, since apparently no sufficient plasma level was obtained, wherefore also a following permanent drop infusion is recommended. The rate of side-effects was insignificant and in no case led to a withdrawal of the therapy.

Administration, Oral↗

PubMedDate not supplied

[Systolic time interval, stress ergometry and 133-xenon clearance in obesity].

Systolic time intervals were measured with 55 middle aged healthy normal weight and 76 healthy overweight probands in two positions (standing and lying). In 39 adipose patients and 55 normal weight subjects an ergometric work was carried out. A significant difference between normal and extremely adipose subjects without cardiac diseases could not be noticed with regard to the preejection index. Preejection period and left ventricular ejection time showed significant differences in both positions between normal and overweight probands, independent of blood pressure. In overweight patients there was a significantly decreased heart work load. The preejection index of adipose patients with a work load below 76 watts amounted to a mean value of 1,04. A work load of 100 watts was reached by only half of the adipose patients. In 32 adipose subjects with a heart work load above 75 watts the regulation of heart-rate and blood-pressure was not different from that of normal weight persons. Muscle blood flow was measured by 133Xenon-Clearance after Lassen et al. The measurement of the 133Xenon-Clearance of the arm muscle at rest in 29 adipose patients resulted in significantly lower values compared with normal weight persons.

Adult↗

PubMedDate not supplied

[Systolic time interval as a means of evaluating the cardiac functional capacity in patients with and without heart insufficiency].

Determining the systolic time intervals in a non-invasive method which is easy to apply and inexpensive, and it can be repeated as many times as necessary. The patient is subjected to low psychic stress so that even elderly and sick patients may undergo it. The STI method may be applied to case control and the observation of the development of a disease following pharmacological treatment. The method makes it possible to differentiate between healthy persons and patients suffering from cardiac insufficiency, and concealed insufficiencies of the cardiac circulation may be detected. The STI interpretation must take into account those factors which have an effect on the STI length. The results can be considerably upgraded through the use of certain indices, PI being the main one. The PI index is of particular value if the effect of the treatment by glycoside medication is to be observed.

Aged↗