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Biomedical subjects

B Kruslin

Publications and source records attributed to B Kruslin.

34 records · Page 2Linked to original sources
PubMed1997

Epithelial hyperplastic lesions of the larynx in biopsy specimens.

Surgical biopsy files for the period 1991-92 were reviewed to determine the relative proportion and types of epithelial hyperplastic lesions of the larynx as well as sex and age distribution and correlation between clinical and histopathological diagnoses. In this period 203 laryngeal biopsies from 187 patients were analyzed. Epithelial hyperplastic lesions were found in 42 males and 9 females. There were 39 cases with keratosis and 12 cases showing keratosis with atypia. Correlation between clinical diagnoses and pathohistological findings was established in only 5 cases (9.8%), clinically diagnosed as leukoplakia; an additional 5 cases (9.8%) were clinically diagnosed as chronic laryngitis. The majority of clinical diagnoses in cases with epithelial hyperplastic lesions were laryngeal neoplasm (29, 56.9%) followed by laryngeal polyp in 9 cases (17.6%). We conclude that for correct diagnosis the biopsy should be performed in all patients with clinical symptoms showing laryngoscopic alterations that suggest a potentially malignant lesion.

Biopsy↗
PubMed1997

Invasive breast carcinoma with granulomatous stromal response.

An unusual case of invasive ductal carcinoma of the breast associated with epitheloid granulomas is reported. Multinucleated giant Langhans'-type giant cells were found in the epitheloid granulomas in breast carcinoma, but there were not present in the breast tissue and axillary lymph nodes. Congo-red deposits were found haphazardly in the stroma between tumor cells and granulomas. Numerous mast cells were found surrounding granulomas. The patient lacked any clinical evidence of the systemic granulomatous disease. The presence of epitheloid granulomas, amyloid deposits and numerous mast cells in invasive breast carcinoma could be related to a host immune response towards the tumor.

Aged↗
PubMed1996

Ciliated metaplasia in a patient of Mediterranean origin with gastric adenoma.

We report here the first case of ciliated gastric metaplasia in a Croatian patient. This is also the first case of ciliated metaplasia reported in a patient of Mediterranean descent. Cilia were found in slightly cystically dilated gastric glands underneath a gastric adenoma with severe dysplasia. They were visualized by desmin immunohistochemical stain. Cells that presented with cilia were columnar cells, some of them with vacuolization of the cytoplasm. This case report shows that ciliated metaplasia occurs in patients of Southern European origin.

Adenoma↗
PubMed1995

Multiple genetic alterations in malignant metastatic insulinomas.

Proto-oncogenes, growth factors/receptors, and tumour suppressor genes were analysed in malignant metastatic insulinomas. Normal pancreas showed only a moderate immunoreaction for c-myc proto-oncogene and a strong reaction for insulin. Benign insulinomas were slightly or moderately positive for transforming growth factor alpha (TGF alpha), weakly positive for epidermal growth factor receptor (EGF-R), and strongly positive for c-myc and insulin. In malignant insulinomas, besides a strong immunoreaction for c-myc and TGF alpha, activation of c-K-ras and overexpression of p53 protein were found. Insulin reaction was moderate or strong. Three out of six malignant insulinomas displayed a c-K-ras point mutation at codon 12. All mutations were guanine to cytosine transversion, resulting in amino acid substitution, glycine to arginine. Mutations were present in metastatic insulinomas only. Patients with mutated c-K-ras oncogene had overexpression of p53 protein as well as c-myc and TGF alpha overexpression. Our results support the view that malignant progression is a consequence of more than one genetic lesion and suggest that activation of myc, TGF alpha an ras genes plays a role in a multistep process of tumour progression, perhaps serving as an initiating event.

Aged↗
PubMed1995

[Vaginal mixed tumor or spindle cell epithelioma--a case report].

A case of mixed tumor of the vagina or spindle cell epithelioma is presented and the literature on this rare type of tumor is reviewed. Immunohistochemical findings suggest an epithelial origin. Follow-up studies indicate benign behavior. However, recurrent tumors were reported suggesting careful follow-up observation after excision of extended primary tumors.

Adult↗
PubMed1992

Congenital malformations of the respiratory tract.

Malformations of the respiratory tract were found in 21 out of 205 foetuses (10%) in whom various congenital malformations had been prenatally detected by ultrasonography and amniocentesis. Pulmonary hypoplasia was the most common of all pulmonary malformations and was established in 17 cases (81%). Lung alobulation was established in two cases (9.5%), and pulmonary cysts were recorded in another two cases in post-mortem examinations. Correlations established between ultrasonographic and pathomorphological findings were not satisfactory as only 29% of all ultrasonographic diagnosis were complete and correct. Hence, much closer cooperation between the pathologist and clinician is essential to all investigations of congenital malformations, in particular to those of complex nature.

Abortion, Induced↗
PubMed1989

Growth factors in human tumors.

Various human tumor tissues contain different growth factors. In some cases progression of tumors is paralleled by elevated levels of these substances in blood or in tumor tissue. There is evidence that these growth promoting peptides might stimulate tumor growth. The growth of most tumors was associated with insulin-like substances (MW 45,000). We isolated and purified a substance immunologically cross-reactive with insulin (SICRI) from human melanoma. We found the molecular weight of affinity purified SICRI to be approximately 120,000. Our in vitro experiments with human renal carcinoma cells and growth factors suggest an important role of these molecules in tumor progression.

Cell Division↗
PubMedDate not supplied

Oncoproteins and tumor suppressor proteins in congenital sacrococcygeal teratomas.

Congenital sacrococcygeal teratoma (SCT) is the most common germ cell tumor of infancy and childhood with a female preponderance. Most SCTs are diagnosed at birth, are benign, and consist of fully differentiated, mature tissues. Tumorigenesis of SCTs remains poorly understood. Almost nothing is known about possible oncogene activation or tumor suppressor inactivation in these rare tumors. We describe the presence of various oncoproteins and tumor suppressor proteins in eight cases of congenital SCT. The following oncogenes were examined: ras family (c-H-, c-N-, and c-K-ras), early genes (fos, jun), and tumor suppressor genes (p53 and nm23-H-I). There was no relationship between the intensity of expression of these oncoproteins and tumor suppressor genes and the following parameters: tumor size, age, and survival of the patients. We did not observe any difference, however, between the expression of the examined oncogenes and tumor suppressor genes nm23 and p53 in immature and mature teratomas. Our findings suggest that the ras family of oncogenes, fos and jun oncogenes, and nm23 and p53 tumor suppressor genes are present in congenital SCT, indicating a possible role in genesis and development of these tumors.

Child, Preschool↗
PubMedDate not supplied

Parachordoma: a case report.

Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient. The tumor occurred in the subcutaneous tissue of the left hand as a painless, fixed, slow-growing mass. Pathologic analysis revealed a tumor composed of lobules of cells with variably vacuolated cytoplasm (physaliphorous cells) separated by fibrous septa, predominantly arranged in peculiar small or large alveolar structures. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin 8/18, S-100 protein and vimentin. The patient is well and without recurrence 20 months after surgery.

Adult↗
PubMedDate not supplied

Salivary duct carcinoma metastasizing to the small bowel.

We report a case of salivary duct carcinoma in a 47-year-old woman. The patient presented with symptoms simulating acute appendicitis. Surgery revealed metastatic tumor in the wall of the small bowel. Two months later, a tumor of the right parotid gland was resected, and histologic analysis revealed a salivary duct carcinoma. To our knowledge, this is the first case of salivary duct carcinoma metastasizing to the small bowel with manifestations of metastatic disease as the prominent symptom.

Carcinoma↗
PubMedDate not supplied

[Carcinoma of the urinary bladder resembling lymphoepithelioma].

Lymphoepithelioma-like carcinoma of the bladder is rare and has only recently been described at this site. We report a case of lymphoepithelioma-like carcinoma of the urinary bladder in a 70-years old male patient who presented with painless hematuria lasting for one month. The patient underwent transurethral resection two times. Histopathologic diagnosis was transitional cell carcinoma. Histopathologic examination of the third biopsy showed tumor tissue with typical syncitial growth pattern of atypical, large, epitheloid cells with ill-defined cytoplasmic borders, prominent nucleoli and numerous mitoses. A prominent lymphocytic infiltrate was found as a component of the tumor. Immunohistochemistry showed positive reaction for cytokeratin and epithelial membrane antigen, and negative results for leukocyte common antigen, CD3, CD20, CD30, CD68 and PSA. The lymphoid infiltrate was an admixture of T and B cells. The tumor invaded the muscle wall. After last surgery the patient underwent chemotherapy by local application of Adriablastine. At present the patient is without recurrence 10 months after the last surgery.

Aged↗
PubMedDate not supplied

[Relation between grades of histologic differentiation and hormone receptors in breast cancer].

The relationship between the grade of histologic differentiation of the tumor and estrogen (ER) and progesterone (PgR) receptor values was analyzed in 261 patients with breast cancer of the invasive duct type. There was a statistically significant difference in concentration and incidence of positive and negative ER and PgR with regard to histologic grade. The concentration and number of positive hormone receptors increased with better differentiation of the tumor. A statistically significant correlation between histologic grade, hormone receptor values and axillary nodal involvement was obtained only in patients with no metastases to axillary lymph nodes.

Breast Neoplasms↗
PubMedDate not supplied

[Pathohistologic procedures in encapsulated follicular tumors of the thyroid gland].

Determination of pathohistologic diagnosis of encapsulated thyroid tumors, particularly follicular carcinoma, is sometimes very difficult, even for well-experienced pathologists. The analysis of intraoperative biopsies could be even more difficult. The importance of proper handling of bioptic material for correct interpretation of pathohistologic findings is not adequately stressed in our literature. In this article, we point out necessity of serial sections of encapsulated follicular tumors for correct diagnosis.

Adenocarcinoma, Follicular↗
PubMedDate not supplied

[Congenital anomalies of the central nervous system 1990-1993].

We have analyzed all available data including birth certificates, maternity records, pediatric records, and pathology reports of spontaneous and induced abortions and newborn deaths to determine the frequency of congenital anomalies of the central nervous system. We found 76 infants (34 males, 39 females and 3 of undetermined sex) with CNS anomalies during the 1990-93 period. In the same period there were 23,425 births. The frequency of CNS anomalies in this period was 32,4/10,000 births. These results are at variance with conclusions of previously published and incomprehensive studies in Croatia. Therefore, a systematic follow-up of the autopsy findings of induced and spontaneous abortions and newborn deaths in the epidemiology of CNS anomalies is clearly needed.

Central Nervous System↗
PubMedDate not supplied

[Prognostic value of determination of the presence and histologic grade of the intraductal component in invasive ductal carcinoma of the breast after conservative treatment].

In recent years, breast-conserving therapy and radiation therapy have become an important treatment option for patients with stage I and II invasive breast cancer. The results of long-term retrospective studies have demonstrated that this treatment can provide a high level of local tumor control with satisfactory cosmetic results. Numerous studies have shown that the presence of extensive intraductal component (prominent intraductal carcinoma) is highly associated with subsequent local recurrence. In this article we have stressed the value of the determination of the presence and the histologic grade of prominent intraductal component of invasive ductal breast carcinoma in the determination of the extent of surgery. We also point out the possibility of determination of prominent DCIS on frozen sections.

Adult↗