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Biomedical subjects

B Kuczewska

Publications and source records attributed to B Kuczewska.

6 recordsLinked to original sources
PubMed1987

The influence of cimetidine and ranitidine on basophil histamine release and bronchial reactivity in asthmatic patients.

Anti-IgE induced histamine release from isolated basophils after Cimetidine and Ranitidine administration was evaluated in 22 patients with atopic bronchial asthma. The histamine provocation test after Ranitidine treatment in 10 patients with atopic bronchial asthma and 10 patients with peptic ulcer was also performed. Investigations in vitro revealed that Cimetidine and Ranitidine in low concentrations had an inhibitory effect whereas in concentrations of over 10(-6) M and 10(-4) M, respectively, they enhanced histamine release. Investigations in vivo after administration of Ranitidine showed that it does not cause marked changes in the bronchial reactivity in patients with bronchial asthma and any change in patients with peptic ulcer. These preliminary studies seem to suggest that in patients with atopic bronchial asthma and concomitant peptic ulcer Ranitidine is preferable to Cimetidine in the treatment of digestive tract disorders.

Antibodies, Anti-Idiotypic↗
PubMed1986

Immunologic histamine release from isolated human basophils during specific immunotherapy.

Anti-IgE- and antigen-induced histamine release from basophils isolated from 20 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with Pollinex. It was shown, that after hyposensitization a significant decrease on anti-IgE and specific antigen-induced histamine release from basophils occurs.

Allergens↗
PubMed1985

The effect of short-term immunotherapy with Pollinex on anti-IgE and antigen-induced histamine release from sensitive human basophils.

Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunotherapy a significant drop in anti-IgE and specific antigen-induced histamine release from isolated basophils occurs. The investigations confirm that the diminution of the target cell sensitivity and releasability may be one of the effects of specific immunotherapy.

Aldehydes↗
PubMed1984

The effect of H1 and H2 receptor blockers on immunological and nonspecific histamine release from isolated target cells.

The investigations were carried out on isolated peritoneal rat mast cells and human basophils. Cell histamine release was induced by a specific antigen, anti-IgE and by compound 48/80. Mepyramine and Diphenhydramine were used as H1 receptor blockers and Cimetidine as H2 receptor blocker. It was shown that effect of H1 and H2 receptor blockers on histamine release depends on concentration of drugs used in experiments, on the presence of exogenous histamine in the medium, on the kind of histamine liberators and also on the type of investigated target cells. The results obtained seem to indicate the presence of H2 receptors not only on basophils but also on mast cells.

Animals↗