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Biomedical subjects

B Kuntz

Publications and source records attributed to B Kuntz.

13 recordsLinked to original sources
PubMed1979

HLA-A, -B, and -D antigens in paralytic poliomyelitis.

Sixty-two unrelated Caucasian patients from the Munich area who had had paralytic poliomyelitis in the 1950s and the early 1960s were analyzed. HLA-A and -B typing was performed for 26 antigens. HLA-D tying was done using six different established homozygous typing cells defining the specificities Dw1-Dw5 and Dw11, plus one locally defined typing cell. None of the HLA-A, -B or -D determinants showed a significant deviation in frequency from control populations. Of interest may be a decrease of B8 and an increase of Bw16 (Bw38/39) and B27, but these deviations are not significant in their P values are corrected for the number of comparisons made.

Adolescent↗
PubMed1978

HLA--D typing in 72 psoriasis vulgaris patients: distribution of seven HLA--D alleles.

The phenotype distribution of seven HLA--D alleles among 72 unrelated Psoriasis vulgaris patients was investigated. Statistically significant deviation from the antigen frequency in healthy donors was found for a new HLA--D allele, locally designated EI, with a relative risk value of 5.97. This observation indicates that Psoriasis vulgaris belongs to the group of diseases with associations to HLA--B as well as HLA--D alleles.

Alleles↗
PubMed1977

B- and T-cell-specific alloantigens in man.

Screening for B-cell-specific antibodies in unabsorbed pregnancy sera preselected for weak reactivity in regular HLA-A, -B, and -C screening yielded a relatively high proportion (35/81) of B-cell-specific antibodies. Most B-cell-specific antibodies react broadly, showing inclusion phenomena suggesting 'cross-reactivity' analogous to that observed in HLA-A and -B serology. In control experiments with T-cell-enriched suspensions three antisera reacted with T cells and not with B cells. These antisera are highly associated with HLA-A2 in the unrelated population and segregate with HLA haplotypes in families and with HLA-A in a family with HLA-A, B recombination, Thus it appears that the human equivalents of Ia antigens may include--in analogy to the murine Ia antigens--B cell- as well as T-cell-specific alloantigens.

Antibody Specificity↗
PubMed1977

Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.

The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters, and chi-square values were determined both from the genotype and from the phenotype data. Although the HLA-B,Bf associations involve antigens that are also present in the highly associated A,B and B,D haplotypes of the Caucasian population, there was--with the possible exception of HLA-A3,B7,Bf-S--no significant three-point association for HLA-A,B,Bf.

Adult↗
PubMed1976

Investigations of red cell glyoxalase in recombinant families.

The polymorphism of the red cell glyoxalase (GLO), which has recently been found to be linked with the major histocompatibility complex (HLA) in man, was investigated in a number of selected families showing various recombinations between HLA-A, HLA-B and the third locus of the phosphoglucomutase (PGM3). In two families with a recombination between HLA-A and HLA-B, the GLO allele travels with the HLA-B locus fragment of the chromosome, indicating that GLO is located on the side of the HLA-B locus. In other families, recombinations occurred between HLA-A and B on one side and GLO and PGM3 on the other side, demonstrating that GLO and PGM3 are located on the same side of HLA. Other recombinations separated PGM3 from GLO so that it can be assumed that GLO is located between HLA-B and PGM3. Thus the immunogenetic linkage group on human chromosome C6 has been increased by yet another outside marker gene to include now the following genes in this order: HLA-A--HLA-C--HLA-B--Bf--HLA-D--GLO--PGM3.

Chromosome Mapping↗
PubMedDate not supplied

Saline locks in prehospital care.

OBJECTIVES: 1) To determine if paramedics could select appropriate patients for use of the saline lock; 2) to evaluate saline-lock patency upon arrival at the emergency department (ED); and 3) to define any cost-savings associated with the use of the saline lock. POPULATION: Patients in the prehospital setting who required intravenous (IV) access, but did not require fluid resuscitation. Patients with hypotension or multiple traumatic injuries were excluded. METHODS: Paramedics were given the option for the use of either the saline lock or a routine IV set-up. Initially, the reservoir was flushed with 1 ml 0.9 N saline solution and the flush was repeated only if medications subsequently were completed for each patient. Information collected included: 1) demographics; 2) reason for selection; 3) need for fluid infusion; 4) conversion of the lock to a routine IV set-up; and 5) administration of medications through the lock. Failures included inability to flush after arrival to the ED, or local infiltration detected on flush while in the ED. Costs associated with the use of the saline locks were compared with those associated with the use of traditional IV set-ups. Cost-savings were calculated as the cost of a traditional IV set-up minus costs of the lock set-up. RESULTS: A total of 58 male and 42 female patients was enrolled. All patients were assigned appropriately. The most commonly used indications included chest pain, possible stroke, and shortness of breath. Two locks were occluded, and two had infiltrated when flushed following arrival of the patient to the ED. Five patients had IV fluid loads initiated through the locks. Cumulative cost-saving were [U.S.]$130 to the hospitals and $1,710 to the patients or their carriers. Most paramedics were pleased with the performance and utility of the locks. CONCLUSIONS: The use of saline locks is an alternative to the use of traditional IVs in certain patients in the prehospital setting.

Adolescent↗
PubMedDate not supplied

Exploring the grief of adolescents after the death of a parent.

This study explored the grief of 26 adolescents after the death of a parent during the subjects' adolescent years. Data collection involved a one-time semi-structured interview. In addition, the adolescents were asked to write and draw about death. The study identified variables and themes that appeared to have possible significance for how adolescents coped. The study conclusions were that adolescents do grieve differently from children and differently from adults; younger adolescents even grieve differently from older adolescents. No discernible differences in grieving were ascertained on the basis of sex, type of death, or prior loss experiences. The one adolescent who was perceived as grieving in an adaptive manner had the advantage of open communication with family members, had closure with the parent now dead, had seen the parent when dead, and had been involved with the rituals surrounding the death. Implications for future research and recommendations for adults involved with adolescents are included.

Adaptation, Psychological↗