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Biomedical subjects

B L Bailey

Publications and source records attributed to B L Bailey.

7 recordsLinked to original sources
PubMed1995

Urinalysis predictive of urine culture results.

BACKGROUND: Most clinicians treat patients for presumptive urinary tract infections based on urinalysis findings. Which of these findings is the best predictor of infection? METHODS: A retrospective cross-sectional study of 202 serial subjects of all ages was conducted over 8 months in a typical family medicine setting. Urinalysis and culture were performed concurrently. RESULTS: The best predictors for significant bacteriuria (defined as a culture with more than 50,000 colony-forming units) were > or = 2+ bacteriuria (sensitivity, 0.74; specificity, 0.80), or > or = 10 white blood cells per high-power field (sensitivity, 0.816; specificity, 0.651), or a positive nitrite test (sensitivity, 0.395; specificity, 0.929). The optimal combination of any two of the three predictor variables also was determined. CONCLUSIONS: Standard urinalysis results can be highly predictive of infection in typical family practice patients.

Adolescent↗
PubMed1987

Malpractice and periodontal disease.

The treatment of periodontal disease is, at the present time, the focus of a large percentage of all dental malpractice cases. Consequently, dentists may find it helpful to be aware of the somewhat unique nature of litigation arising out of professional services provided with respect to periodontal disease. The operation of the statute of limitations in this context, whereby a dentist--at least in many states--can be sued several years after treatment of a patient terminates, makes caution, in terms of the maintenance of records and the purchase of insurance, an absolute essential.

Dental Records↗
PubMed1985

Cooperativity among calmodulin's drug binding sites.

The binding of felodipine, a dihydropyridine Ca2+ antagonist, to calmodulin has been studied by equilibrium dialysis and fluorescence techniques. Analysis using the Hill equation gives a Hill coefficient of 2. A plot of bound [felodipine] vs. free [felodipine]2 gives a Bmax of 1.9 mol/mol and a K0.5 of 22 microM. Two calmodulin antagonists, prenylamine and R24571, which have previously been shown to potentiate the fluorescent enhancement observed when felodipine binds to calmodulin [Johnson, J. D. (1983) Biochem. Biophys. Res. Commun. 112, 787], produce a reduction in Hill coefficient to 0.7 and 1.0, respectively, and account for the observed potentiation of felodipine binding. Titrations of felodipine with calmodulin in the absence and presence of prenylamine and R24571 suggest that these drugs decrease the K0.5 of calmodulin for felodipine by 25-fold. Thus, potentiating drugs (prenylamine and R24571) bind to either of the two felodipine binding sites and, through an allosteric mechanism, result in felodipine binding to the remaining site with greatly enhanced affinity. Two types of potentiating drugs are observed. Prenylamine exhibits a Hill coefficient of 0.8 whereas felodipine, R24571, and diltiazem exhibit Hill coefficients of 2 in their potentiation of felodipine binding. Titrations of felodipine and calmodulin with Ca2+ exhibit cooperativity with a Hill coefficient of 4. Half-maximal binding occurs near pCa 6.0. In the presence of R24571, the calcium dependence of felodipine binding is biphasic, now exhibiting a much higher affinity (pCa 7.6) component. A model is presented to explain the relationship of these various allosterically regulated conformers of calmodulin and their interactions and activation with its target proteins.

Antihypertensive Agents↗
PubMed1985

Informed consent in dentistry.

This article discusses the doctrine of informed consent and its impact on the practice of dentistry. It summarizes relevant case and statutes, and stresses the uncertainty that prevails in this area of the law. A procedure is set forth for dentists to follow on an everyday basis that will assist them in the event that they become involved in litigation based on allegations of uninformed consent.

Consent Forms↗