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Biomedical subjects

B L Cherkasskiĭ

Publications and source records attributed to B L Cherkasskiĭ.

At least 19 recordsLinked to original sources
PubMed1994

[The differential diagnosis of anthrax in man].

The paper reports group cases of the disease running as anthrax. The disease was not identified etiologically. The authors hold that it is important to make differential diagnosis of anthrax with necrobacillosis, pasteurellosis and contact pustular viral dermatitis. Laboratory and clinical diagnostic techniques are specified.

Adult↗
PubMed1992

[The leading routes and factors in the transmission of the causative agent of campylobacteriosis under current conditions].

Epidemiological investigations carried out at the foci of Campylobacter infection in Moscow and the Moscow region in 1987-1990 demonstrated that Campylobacter infection was recently registered as sporadic cases in a few foci. The alimentary route of the transmission of this infection was the main factor of its spread. A high role of everyday contacts in the spread of this infection was noted. The possibility for outbreaks and sporadic cases of Campylobacter infection to be masked by very frequently occurring associations of these bacteria is discussed.

Adult↗
PubMed1991

[An immunoenzyme test system for the detection of antibodies to Campylobacter].

An enzyme immunoassay system for the detection of antibodies to bacteria of the genus Campylobacter in human blood serum has been developed. The system is based on the use of ethanol-treated C. jejuni and C. coli whole cells as antigen. The study of sera obtained from healthy donors in this assay has made it possible to establish the value of the tentative diagnostic titer: 320.

Animals↗
PubMed1991

[The epidemiological aspects of campylobacteriosis in children in arid area].

Specific epidemiological features of Campylobacter infection in children in Samarkand Province during the period of 1987-1990 are discussed. The specific proportion of this infection in the total structure of acute enteric infections was, on the average, 8.5%, and Campylobacter carriership among healthy children, 7.0%. Among children with Campylobacter infection, children aged up to 1 year constituted 71.5%. The results of the study of the biological properties of Campylobacter strains isolated from sick and healthy children and their difference from strains isolated in other regions are discussed.

Age Factors↗
PubMed1991

[Risk factors and transmission routes of the causative agents of campylobacteriosis in commercial poultry plants].

The study, carried out in two regions of the USSR and aimed at estimation of the contamination of products supplied by industrial poultry complexes (IPC), revealed that the contamination of these products was closely related to the Campylobacter contamination of the personnel of IPC. The causes of high Campylobacter contamination of the products of IPC at all technological stages of their production are described. The species, serovars and biovars of Campylobacter strains isolated from different sources were determined, which made it possible to carry out the specific and intraspecific differentiation of these strains.

Animals↗
PubMed1991

[The laboratory diagnosis of campylobacteriosis today].

Different conditions necessary for the successful isolation and cultivation of Campylobacter (culture media, inoculation techniques, gas mixtures, etc.) are described. Of these, the most effective conditions and methods, as well as those available for practical health service, have been determined. The main trends in further improvement of the laboratory diagnosis of Campylobacter infection is presented.

Acute Disease↗
PubMed1990

[The effect of the protective antigen of Bacillus anthracis on the formation of immunity under the action of live anthrax vaccines].

The preparation of low-molecular protective antigen (PA) isolated from strain 34F2 (Sterne) and having a molecular weight of 34 and 51 kD, unlike the preparation of high-molecular PA with a molecular weight of 87 kD, suppressed the formation of acquired resistance to anthrax when introduced into guinea pigs in mixture with live spores of strains of STI, 34F2 and new vaccine strain 228/8; this phenomenon was mainly accompanied by a decrease in the level of antibodies to lethal factor (LF) nad in the antitoxic activity of blood serum. The immunosuppressing action of low-molecular PA depended on the kind of vaccine strain introduced together with this antigen, which suggested the existence of differences in the ligand determinants of strains 34F2 and STI. In contrast to high-molecular PA, low-molecular PA blocked the action of the lethal mixture of PA and LF on the culture of peritoneal mononuclear phagocytes of CBA mice. The competitive relationships between low-molecular PA and high-molecular PA are discussed.

Animals↗
PubMed1990

[Postinfection and postvaccinal antianthrax immunity in human subjects].

Antibodies to Bacillus anthracis protective antigen (PA) and to the lethal factor (LF) of B. anthracis exotoxin in the blood sera of anthrax patients and of subjects with a history of the disease, as well as of persons immunized with STI live vaccine, were studied by the heterogeneous enzyme immunoassay. In 1-6 years after convalescence the levels of anti-PA and anti-LF antibodies (at 75% and 96% detection rates respectively) were higher than on weeks 1-4 from the onset of the disease. In persons having had anthrax antibodies belonged mainly to IgG, and the anti-LF antibody level was higher than the anti-PA antibody level. In persons immunized with STI vaccine the detection rate of antibodies somewhat increased in 2-7 months after immunization, reaching, on the average, 72%, the antibody levels after primary immunization and regular annual booster immunization being similar. In 1-2 years after primary (booster) immunization the isolation rate of antibodies decreases to 21%. Specific features of postinfectious and postvaccinal immunity to anthrax and problems of retrospective diagnosis of this disease are discussed.

Adult↗
PubMed1989

[The detection of specific antigens in experimental anthrax].

The dynamics of various specific antigens was studied in guinea pigs infected with strain 72/12 of Tsenkovskiĭ's second vaccine. The study showed that at the acute stage of the disease toxin antigens prevailed over the levels of somatic antigens and nonprotective protein with a molecular weight of 79 KD. The enzyme immunoassay system for the detection of the lethal toxin factor permitted the detection of the antigen in the blood sera of 100% of infected animals at the prodromal period and the acute stage of the disease. In pathological material obtained from skin lesions the presence of toxin antigens and nonprotective protein was registered in 90-100% of the animals. The diagnostic significance of these assays for the early rapid diagnosis of anthrax during lifetime, as well as for the postmortem rapid diagnosis of the disease.

Animals↗
PubMed1989

[Clinico-epidemiologic aspects of campylobacteriosis in Moscow and Moscow Province].

The clinical course and epidemiological features of campylobacteriosis in Moscow and Moscow Province in 1986-1987 are described. The specific proportion of this infection in the structure of acute enteric infections is, on the average, 4.8%. The level of Campylobacter contamination of animals and birds and their role in the spread of campylobacteriosis have been established. The possible ways and factors of the transfer of this infection are discussed.

Acute Disease↗