A comparison of two hard-copy display systems for nuclear medicine images.
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Biomedical subjects
Publications and source records attributed to B L Diffey.
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The response of plasma-25-hydroxyvitamin D (25[OH]D) to different exposures to ultraviolet irradiation has been studied in patients in long-stay geriatric wards. Increases sufficient to bring the plasma-25(OH)D into the normal range may be obtained with doses less than those required to produce erythema. The provision of such background irradiation may be a suitable method of preventing vitamin-D deficiency in elderly subjects who receive very little exposure to sunlight.
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The production and optical properties of a dosemeter for natural ultraviolet radiation are descirbed. The physical form of the dosemeter is a thin polymer film which incorporates 8-methoxypsoralen as the chromophore. The dosemeter responds to ultraviolet radiation at wavelengths up to 380 nm and is suitable for quantifying the UV exposure of patients suffering from some idiopathic photodermatoses or drug photosensitivity.
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Measurements have been made of the anatomical distribution of ultraviolet radiation resulting from the irradiation of an inanimate manikin in a PUVA 6000 unit and a PUVA 4000 unit. The dosimeter used was phenothiazine film. The results indicated a very similar pattern of relative UV dose on the surface of the manikin from both units.
Preliminary work on a dosimeter suitable for measuring UVR exposure on individual persons is described. It is based on the use of polysulfone film which, on exposure, shows a change in absorbance that is determined spectrophotometrically. The results of studies of groups of persons with vastly different degrees of solar exposure, e.g., outdoor and indoor workers and geriatric patients, and psychiatric patients with photosensitivity from phenothiazine drugs are presented. We consider the dosimeter may also be suitable for epidemiologic studies in sunlight-induced skin cancer.
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Empirical equations based upon experimental measurements of Bener (1972) have been developed which allow the computation of the spectral distribution of global ultraviolet radiation encountered at sea level under clear day conditions for any desired time of day, day of year and geographical latitude.
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The relative distribution of natural ultraviolet radiation has been measured at ten sites on the surface of an unclothed manikin for 2 h around solar noon on 19 different days during late summer in Canterbury, U.K. The dosimeter used was polysulphone film. The results obtained indicate that vertical surfaces of the body receive about one half of the dose relative to the vertex and that the relative doses at different sites are independent of weather conditions.
A hypothetical action spectrum for the regression of lesions in photochemotherapy of psoriasis is proposed. An ideal detector should have a wavelength response which matches this action spectrum but this is generally not the case with commercially available photometers. The problems that may arise by indiscriminate use of such detectors are discussed, together with a suggested solution.
A polymer film, which incorporates phenothiazine as the chromophore, has been developed as a personnel dosimeter for long wave ultraviolet radiation. It is stable, reproducible and is particularly suited to monitoring the doses received by patients undergoing photochemotherapy for psoriasis.
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