Naproxen premedication for laparoscopic sterilization.
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Biomedical subjects
Publications and source records attributed to B L Duffy.
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The analgesic effect of intramuscular ketorolac was assessed by double blind study in forty women presenting for day-case laparoscopic sterilisation. The patients were randomly allocated to receive either ketorolac 30 mg or saline by intramuscular injection immediately following induction of general anaesthesia. There was no statistically significant difference between the groups in pain scores, opioid requirements or incidence of nausea and vomiting in the postoperative period. In view of the potential side-effects of ketorolac, and the apparent lack of efficacy when used prophylactically, the routine use of the drug in this group of patients cannot be recommended.
A case of the HELLP syndrome in a pregnant woman, which was diagnosed initially as obstructive cholecystitis, is presented. The diagnostic difficulties and some management problems are discussed. Practitioners should be aware of the HELLP syndrome and related conditions when caring for pregnant patients.
Four pregnant patients are described who had varying signs of pre-eclampsia plus haemolysis, elevated liver enzymes and a low platelet count. Two of the patients presented without hypertension and all posed considerable diagnostic difficulties, with problems in clinical management. Pregnancy induced hypertension is only one manifestation of a much more diverse pathophysiological process. Anaesthetists need to be aware of these other pregnancy related disorders in order to avoid diagnostic pitfalls and to enable them to provide safely the appropriate general and regional anaesthetic techniques.
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Forty patients presenting for vaginal termination of pregnancy, divided randomly into four groups, received either no medication, sodium citrate 30 ml orally, ranitidine 150 mg orally or ranitidine 50 mg intravenously. During the procedure, gastric contents were removed by orogastric tube for volume and pH measurements. Ranitidine, orally and intravenously, significantly increased gastric pH and reduced gastric volume. In the control group only one pH was greater than 2.5. Sodium citrate raised the pH above 2.5 in 6 out of 10 patients. Fasting patients in the first months of pregnancy may be at risk of developing Mendelson's syndrome. Ranitidine is very effective in increasing gastric pH and at the same time reducing gastric volume in such patients.
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Epidural pethidine was compared with epidural saline for relief of pain from episiotomy wounds. Pethidine 25 mg administered by the lumbar epidural route produced significant analgesia. However, the incidence and severity of episiotomy pain are so variable that routine use of the technique is not recommended.
The reliability in providing a continued venous route to the circulation is compared between a winged needle (Abbott "Butterfly--23 INT") and a plastic catheter (Jelco Teflon "Catheter Placement Unit", 22 gauge). The catheter remained within the vein in all cases and had a much lower incidence of total obstruction during the study period. Where an intravenous infusion is not in place, a plastic catheter provides a more reliable access route to the circulation than does a winged needle.
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Conventional dressings do not always prevent epidural catheter movement into or out of the epidural space. Lack of transparency also prevents observation of the catheter and the puncture site. The "Op-site" surgical dressing is an adherent membrane which has prevented epidural catheter migration in 200 obstetrical patients. The transparent dressing was left uncovered in 100 of these patients so that the catheter could be readily seen and the presence of blood within the catheter could be detected at any time.
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