Biomedical subjects

B L Garland

Publications and source records attributed to B L Garland.

2 recordsLinked to original sources

PubMed1983

Possible receptor effects of chronic lithium administration.

This article will review the possible effects of chronic administration of lithium on behavioral studies and on receptor binding. Evidence suggests that lithium pretreatment might be effective in blocking the development of pharmacologically-induced behavioral dopamine supersensitivity although alterations in receptor binding may not be directly correlated to behavioral changes. Experimental results indicate that the effect of lithium may not be consistent throughout the brain, may be related to specific methods of sensitivity-induced alterations and may simultaneously alter several receptor systems.

Animals↗

PubMed1982

A second generation catecholamine hypothesis.

The catecholamine hypothesis proposed an increase in functional brain norepinephrine in the manic phase of manic-depressive illness. This paper reviews a secondary hypothesis suggesting that dopamine may be involved in the manic process. Increases in functional dopamine may result from the release of dopamine which is amplified by a supersensitive dopamine receptor that has developed during the depressive phase prior to the onset of mania. Lithium may act, in part, by blocking the development of supersensitive dopamine receptors. Evidence compatible with this hypothesis is reviewed.

Animals↗