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Biomedical subjects

B L Giammara

Publications and source records attributed to B L Giammara.

6 recordsLinked to original sources
PubMed1988

Biomaterials and biomedical devices.

This review discusses the factors important in the incorporation or integration of biomaterials and devices by tissue. Methods for surface modification and surface-sensitive techniques for analysis are cited. In vitro methods to evaluate the biocompatibility or efficacy of certain biomaterials and devices are presented. Present and future directions in neural prostheses, cardiovascular materials, blood or bone substitutes, controlled drug delivery, orthopedic prostheses, dental materials, artificial organs, plasma- and cytapheresis, and dialysis are discussed.

Artificial Organs↗
PubMed1986

Epoxy-slide embedment of cytochemically stained tissues and cultured cells for light and electron microscopy.

A new method is described for embedding stained tissue sections, cells, cultured cells or organ cultures in a special polyethylene mold to form epoxy microscope slides (cast-a-slides). Cast-a-slides in which biological specimens are embedded may be examined by light microscopy and individual optimally stained cells or tissue areas selected for examination by various modes of electron microscopy or X-ray microanalysis. Cultured cells or organs can be grown, fixed, stained and embedded in epoxy in the same cast-a-slide mold. The cast-a-slides can be stored conveniently in the same manner as glass microscopy slides.

Animals↗
PubMed1983

Neutrophil pseudoplatelets: their discrimination by myeloperoxidase demonstration.

Neutrophils, especially in acute infection or the myeloid leukemias, may shed platelet-sized particles that can readily be distinguished from true platelets because they contain neutrophil myeloperoxidase. This enzyme, unlike platelet peroxidase, is not inhibited by glutaraldehyde. The myeloperoxidase and acid hydrolase levels and continuous plasma membranes of these cell-like particles suggest that they are functional cellular entities. They further differ from platelets in that they contain nuclear remnants, occur in bacteria-laden pus and inflammatory exudates, are ingested by macrophages, and do not adhere to each other or aggregate. They could be involved in the immune response to pathogens or contribute to trauma and healing by facilitating deployment of neutrophil acid hydrolase, neutral protease, and myeloperoxidase.

Blood Cells↗
PubMed1981

Alterations of oxygen metabolism in experimental bacteremia.

To examine the mechanisms underlying organ failure and disordered cellular metabolism in sepsis, systemic oxygenation, hepatic tissue oxygenation, and hepatic mitochondrial metabolism were studied in rats subjected to an LD100 dose of E. coli bacteria administered intravascularly. The animals maintained normal systemic oxygenation and remained normotensive during the six-hour study period. Hepatic tissue pO2 declined nearly 90% in comparison to controls. Isolated hepatic mitochondria demonstrated statistically increased respiratory control indices that are characteristic of cellular hypoxia. Histologic examination of liver tissue showed obliteration of the sinusoids with debris and cellular aggregates. The data suggest that altered cellular oxygen delivery secondary to sinusoidal obliteration may have significance in hepatic failure and subsequent death in septic patients.

Animals↗
PubMed1977

The ultrastructure of oral neuromas in multiple mucosal neuromas, pheochromocytoma, medullary thyroid carcinoma syndrome.

The ultrastructure of oral neuromas from 2 patients with multiple mucosal neuromas, pheochromocytoma, medullary thyroid carcinoma syndrome reveals numerous hypertrophic unmyelinated and myelinated axons, hyperplastic neurilemmal cells and associated collagen fiber formation. These tumors are described and compared ultrastructurally with neurilemmomas and neurofibromas as described by other authors. On the basis of this comparison, these tumors are not considered to be of neurilemmal origin. On the basis of light and electron microscopic histology it is postulated that these tumors represent hypertrophy of axons similar to that noted in amputation neuromas.

Adolescent↗