Biomedical subjects

B L Maxwell

Publications and source records attributed to B L Maxwell.

2 recordsLinked to original sources

PubMed1979

Polymorphism, genetic stability, and autosomal location of trimeric nucleoside phosphorylase in Peromyscus eremicus cell lines.

Nucleoside phosphorylase (NP: EC 2.4.2.1) has not been demonstrated to be an extensively polymorphic enzyme locus in mammals. We have studied NP electrophoretically in five independently derived cell lines established from Peromyscus eremicus as well as in various tissues of a sixth animal. Four different NP phenotypes involving three different alleles were resolved. The data suggest that (1) the enzyme is trimeric and its genetic locus is polymorphic in P. eremicus, (2) heterozygous enzyme phenotypes are stable during long-term culture, and (3) the enzyme locus is autosomal in Peromyscus.

Alleles↗

PubMed1975

Nucleotide metabolism in Drosophila melanogaster salivary glands during temperature and dinitrophenol-induced puffing.

When Drosophila melanogaster salivary glands are exposed to temperature or dinitrophenol (DNP) treatments, their nucleotide metabolism is altered such that the amount of cellular ATP decreases, whereas the amount of ADP increases. Since both treatments also elicit specific puffing patterns on the salivary gland chromosome, it is suggested that specific loci on the chromosome are activated to form puffs when the efficiency of respiration decreases. The possible relationship between the formation of these puffs and the intramitochondrial metabolism is discussed.

Adenosine Diphosphate↗