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Biomedical subjects

B L Pimstone

Publications and source records attributed to B L Pimstone.

At least 55 records · Page 3Linked to original sources
PubMed1975

Failure of adrenergic alpha and beta receptor blockade to elevate the TSH and prolactin response to TRH in hyperthyroidism.

The effects of adrenergic alpha and beta receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic alpha and beta receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.

Adrenergic alpha-Antagonists↗
PubMed1975

Fasting blunts the TSH response to synthetic thyrotropin-releasing hormone (TRH).

Thyrotropin (TSH) responses to intravenous thyrotropin-releasing hormone (TRH) were studied in 9 men after 12 and 36-h fasts separated by more than a week and performed in random order. The TSH, basally and in response to TRH, was significantly lower after the 36-h fast compared to that after 12 h. The mechanism for this effect is not clear, but may be related to the altered hormonal or fuel status associated with prolonged fasting.

Fasting↗
PubMed1975

Disappearance rates of plasma growth hormone after intravenous somatostatin in renal and liver disease.

Plasma immunoreactive growth hormone (hGH) was measured before, during and after the administration of intravenous somatostatin to 3 patients with chronic renal failure and 4 with severe liver disease who had elevation of basal hGH. During somatostatin infusion, the hGH levels declined acutely in a linear fashion when log hGH was plotted against time. Rather surprisingly, the plasma hGH half disappearance time (t 1/2) was 27 min and 18 min in liver and renal disease respectively. These values do not differ from data obtained on normal subjects using exogenous hGH, labelled or unlabelled. Control data on normal subjects using this technique are not available as it was not possible to measure subnormal levels of plasma hGH with the required precision. It is possible that our findings of plasma hGH T 1/2 in liver and renal disease within the normal range reported using exogenous hGH might suggest that high levels of plasma hGH found in these two diseases are primarily caused by hypersecretion rather than impaired clearance.

Growth Hormone↗
PubMed1975

Prolactin responses to thyrotropin-releasing hromone in protein-calorie malnutrition.

Basal plasma prolactin (hPRL) concentration is low, but the response to thyrotropin-releasing hormone (TRH) is within the normal range, in children with protein-carlorie malnutrition (PCM) before treatment. Treatment results in increased basal hPRL concentration and an increased response to TRH. The above findings contrast with normal or high basal TSH and the normal or exaggerated response to TRH provocation in untreated PCM. The reason for this divergence is obscure.

Child, Preschool↗