Biomedical subjects

B Lütkenhöner

Publications and source records attributed to B Lütkenhöner.

At least 19 recordsLinked to original sources

PubMed2006

No indication of brain reorganization after unilateral ischemic lesions of the auditory cortex.

We used magnetoencephalography to study contralesional auditory reorganization in three men with chronic unilateral ischemic lesions of the auditory cortex. Although no response was found over the lesioned hemisphere, processing in the unaffected hemisphere was indistinguishable vs healthy controls. In contrast to sensorimotor and language systems, the auditory system seems to lack contralateral reorganization, presumably because patients are typically not aware of hearing deficits and thus do not perform training.

Acoustic Stimulation↗

PubMed2006

From noise to pitch: transient and sustained responses of the auditory evoked field.

In recent magnetoencephalographic studies, we established a novel component of the auditory evoked field, which is elicited by a transition from noise to pitch in the absence of a change in energy. It is referred to as the 'pitch onset response'. To extend our understanding of pitch-related neural activity, we compared transient and sustained auditory evoked fields in response to a 2000-ms segment of noise and a subsequent 1000-ms segment of regular interval sound (RIS). RIS provokes the same long-term spectral representation in the auditory system as noise, but is distinguished by a definite pitch, the salience of which depends on the degree of temporal regularity. The stimuli were presented at three steps of increasing regularity and two spectral bandwidths. The auditory evoked fields were recorded from both cerebral hemispheres of twelve subjects with a 37-channel magnetoencephalographic system. Both the transient and the sustained components evoked by noise and RIS were sensitive to spectral bandwidth. Moreover, the pitch salience of the RIS systematically affected the pitch onset response, the sustained field, and the off-response. This indicates that the underlying neural generators reflect the emergence, persistence and offset of perceptual attributes derived from the temporal regularity of a sound.

Acoustic Stimulation↗

PubMed2004

Interaction between the neuromagnetic responses to sound energy onset and pitch onset suggests common generators.

The pitch-onset response (POR) is a negative component of the auditory evoked field which is elicited when the temporal fine structure of a continuous noise is regularized to produce a pitch perception without altering the gross spectral characteristics of the sound. Previously, we showed that the latency of the POR is inversely related to the pitch value and its amplitude is correlated with the salience of the pitch, suggesting that the underlying generators are part of a pitch-processing network [Krumbholz, K., Patterson, R.D., Seither-Preisler, A., Lammertmann, C. & Lütkenhöner, B. (2003) Cereb. Cortex,13, 765-772]. The source of the POR was located near the medial part of Heschl's gyrus. The present study was designed to determine whether the POR originates from the same generators as the energy-onset response (EOR) represented by the N100m/P200m complex. The EOR to the onset of a noise, and the POR to a subsequent transition from noise to pitch, were recorded as the time interval between the noise onset and the transition varied from 500 to 4000 ms. The mean amplitude of the POR increased by approximately 5.9 nA.m with each doubling of the time between noise onset and transition. This suggests an interaction between the POR and the EOR, which may be based on common neural generators.

Acoustic Stimulation↗

PubMed2003

Localization of primary auditory cortex in humans by magnetoencephalography.

Brief auditory stimuli activate the primary auditory cortex (PAC) earlier than any other cortical area so, within a certain latency range, the PAC is the only cortical source contributing to the auditory evoked field (AEF). Nevertheless, there is no AEF component specific to PAC that can be reliably detected in all individuals. The present study suggests that a peak in the first temporal derivative of the magnetic field at about 20 ms (dP20m) is a genuine correlate of PAC activity. AEFs in response to clicks presented to the right ear were recorded with a 37-channel axial gradiometer system positioned over the left hemisphere in nine normal-hearing subjects. More than 8500 stimuli were presented in each of two independent sessions at a rate of approximately 3/s. The dipole coordinates for the dP20m derived from the two sessions typically differed by only a few millimeters. Coregistration of the dipoles with structural magnetic resonance images suggests that dP20m arises from an area close to the retroinsular origin of Heschl's gyrus. Although the dP20m is simply the point of steepest slope on the well-known middle-latency peak, P30m or Pam, it would appear that dP20m and P30m do not have the same cortical origin. Evidence is provided that P30m receives major contributions from at least two distinct cortical areas, only one of which is PAC.

Acoustic Stimulation↗

PubMed2003

Studies of tonotopy based on wave N100 of the auditory evoked field are problematic.

There is still dissension as to whether the auditory evoked field (AEF) reflects tonotopy in the auditory cortex. That notwithstanding, particularly the pronounced AEF wave occurring about 100 ms after stimulus onset (N100 m) is increasingly used for the investigation of issues such as cortical reorganization and representation of virtual pitch. Thus, it appears to be time for a critical revaluation of the supposed tonotopic organization of the N100 m generator. In the present magnetoencephalography study, the response to tonebursts of 500 ms duration, monaurally presented 60 dB above threshold, was recorded with a 37-channel axial gradiometer system over the hemisphere contralateral to the side of stimulation. The stimulus frequencies were 250, 500, 1000, and 2000 Hz. About 250 stimuli of each type were presented in random order in four independent sessions at intervals uniformly distributed between 2 and 2.8 s. An analysis of 19 hemispheres in 10 normal-hearing subjects showed a high intraindividual reproducibility, but also a substantial interindividual variability. In most cases, the dipole location either exhibited no significant frequency dependence at all, the dipoles for the four frequencies were not orderly aligned, or the data disagreed with the single-dipole model. In the few cases showing an arrangement of dipoles consistent with the assumption of an orderly tonotopic cortical map, the most relevant coordinate varied from subject to subject. Regarding theses results, it seems crucial to understand wave N100 m on the basis of individual subjects, whereas conclusions relying on mean dipole locations for groups of subjects are problematic.

Acoustic Stimulation↗

PubMed2003

Neuromagnetic evidence for a pitch processing center in Heschl's gyrus.

There have been several attempts to use the neuromagnetic response to the onset of a tonal sound (N100m) to study pitch processing in auditory cortex. Unfortunately, a large proportion of the N100m is simply a response to the onset of sound energy, independent of whether the sound produces a pitch. The current study describes a novel stimulus paradigm designed to circumvent the energy-onset response and thereby isolate the response of those neural elements specifically involved in pitch processing. The temporal resolution of magnetoencephalography enables us to show that the latency and amplitude of this pitch-onset response (POR) vary with the pitch and pitch strength of the tone. The spatial resolution is sufficient to show that its source lies somewhat anterior and inferior to that of the N100m, probably in the medial part of Heschl's gyrus.

Acoustic Stimulation↗

PubMed2002

Magnetoencephalographic correlates of audiotactile interaction.

To seek for correlates of an interaction between auditory and somatosensory processing, the brain's magnetic field in response to simultaneously presented auditory (A) and tactile (T) stimuli was compared with the sum of the respective unimodal responses (A+T). The stimuli were binaural 1047-Hz tone bursts of 60 dB sensation level and tactile pressure pulses to the right thumb. The mean interval between two stimuli of the same modality was 1.95 s. The magnetic field was recorded using a 306-channel whole-scalp neuromagnetometer. A clear audiotactile interaction was revealed in the hemisphere contralateral to the side of tactile stimulation in six of eight subjects, whereas in the ipsilateral hemisphere an interaction was noticed in only three subjects. The time courses of these audiotactile interaction fields typically showed major deflections of opposite polarities around 140 and 220 ms. The first deflection appeared to arise in the region of the secondary somatosensory cortex (SII). The polarity of this interaction was consistent with the view that the auditory stimulus resulted in a partial inhibition in SII. In two subjects, strong indications of auditory contributions to the interaction were available, although in different hemispheres. The relatively high interindividual variability of the observed interaction, which represents potential neural substrates for multisensory integration, could indicate that the way subjects perceive the simultaneous presentation of auditory and tactile stimuli differs.

Attention↗

PubMed2001

D-amphetamine does not improve outcome of somatosensory training.

BACKGROUND: D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke. OBJECTIVE: To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated. METHODS: Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design. RESULTS: All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine. CONCLUSION: No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.

Adult↗

PubMed2001

Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.

The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.

Acute Disease↗

PubMed2001

Near-DC magnetic fields following a periodic presentation of long-duration tonebursts.

OBJECTIVES: The purpose of this study was to determine the time course of low-frequency (<0.1 Hz) magnetic field components evoked by long-duration tonebursts. The following two questions were of central interest. Does the sustained field (SF) show adaptation as described before for the sustained potential (SP)? How does the field amplitude return to the pre-stimulus baseline after stimulus offset? METHODS: Neuromagnetic measurements were done with a 37-channel first-order gradiometer system. The stimulus was a 1 kHz toneburst of 10 s duration presented at fixed 20 s intervals. The averaged data (high-pass filtered, 0.03 Hz cut-off) were analyzed using the model of an equivalent current dipole with time-invariant location and orientation (fixed dipole). RESULTS: In the grand average of the subjects with the best signal-to-noise ratio, the SF exhibited adaptation with a time constant of 3.6 s. After stimulus offset, the amplitude of the dipole moment dropped to a lower level within 300 ms and decayed exponentially to the baseline thereafter (time constant 2.7 s). CONCLUSIONS: A two-component model is proposed: One component roughly follows the envelope of the stimulus, the other behaves like a leaky integrator. A better understanding of near-DC fields appears to be crucial for the understanding of the relationship between magnetoencephalography and other functional imaging techniques like functional magnetic resonance imaging and positron emission tomography.

Adaptation, Physiological↗

PubMed2001

Functional overlap of finger representations in human SI and SII cortices.

We aimed to find out to what extent functional representations of different fingers of the two hands overlap at the human primary and secondary somatosensory cortices SI and SII. Somatosensory evoked fields (SEFs) were recorded with a 306-channel neuromagnetometer from 8 subjects. Tactile stimuli, produced by diaphragms driven by compressed air, were delivered to the fingertips in three different conditions. First, the right index finger was stimulated once every 2 s. Then two other stimuli were interspersed, in different sessions, to right- or left-hand fingers (thumb, middle finger, or ring finger) between the successive right index finger stimuli. Strengths of the responses to right index finger stimuli were evaluated in each condition. Responses to right index finger stimuli were modeled by three current dipoles, located at the contralateral SI and the SII cortices of both hemispheres. The earliest SI responses, peaking around 65 ms, were suppressed by 18% (P < 0.05) when the intervening stimuli were presented to the same hand; intervening stimuli to the other hand had no effect. The SII responses were bilaterally suppressed by intervening stimuli presented to either hand: in the left SII, the suppression was 39 and 42% (P < 0.01) and in the right SII 67 and 72% (P < 0.001) during left- and right-sided intervening stimuli, respectively. Left- and right-sided intervening stimuli affected similarly the SII responses and had no effect on the response latencies. The results indicate a strong and symmetric overlap of finger representations for both hands in the human SII cortices, and a weaker functional overlap for fingers of the same hand in the SI cortex.

Adult↗

PubMed2000

Brain stem auditory evoked fields in response to clicks.

Magnetoencephalographic correlates of brain stem auditory evoked potentials (BAEP) have been identified by applying the model of a current dipole with invariant location and orientation (fixed dipole) to data recorded with a 37-channel first-order gradiometer system. In all three subjects studied, the dominating wave of the recorded brain stem auditory evoked field (BAEF) coincided exactly with wave V in the contralateral BAEP (maximal field amplitude of the order of 2-3 fT). In one subject, also a wave preceding wave V was observed, which was associated with basically the same spatial pattern as wave V itself, but had an opposite polarity. The study suggests that the supplementary information provided by BAEF measurements could be decisive for a better understanding of human auditory evoked brain stem activity.

Acoustic Stimulation↗

PubMed2000

Efficient neuromagnetic determination of landmarks in the somatosensory cortex.

OBJECTIVES: An efficient procedure for the magnetoencephalographic determination of functional landmarks in the somatosensory cortex has been developed. METHODS: Digits 2-5 are stimulated in randomized order using balloon diaphragms. The interval between two stimuli is 500 ms. Source locations in area 3b are derived by interpreting the field component with a mean latency of 48 ms in terms of an equivalent current dipole. RESULTS: The signal-to-noise ratio achieved in a given time for each of the 4 stimulation sites turned out to be only slightly smaller than the one obtained by stimulating a single site with an optimal interstimulus interval (about 1 s). CONCLUSIONS: Compared to a sequential investigation of the different sites, the proposed procedure allows the reduction of the overall measurement time by a factor of about 2.7.

Adult↗

PubMed2000

Magnetoencephalographic studies of functional organization and plasticity of the human auditory cortex.

Magnetoencephalography has proven to be a powerful noninvasive tool for investigating the functional organization of the human auditory cortex and its plastic changes. The first part of this review summarizes some recent experiments on the tonotopic organization, which can be observed not only in the slow auditory evoked fields, but also in the middle-latency and the steady-state fields. In the second part of this review, recent studies on plasticity of the auditory cortex are outlined. These studies showed that the cortical representation of tones may change within hours after a reversible "functional deafferentation" (short-term plasticity) and that early musical training leads to an expansion in the cortical representation of complex harmonic sounds (long-term plasticity).

Acoustic Stimulation↗

PubMed1999

Short-term plasticity of the human auditory cortex.

Magnetoencephalographic measurements (MEG) were used to examine the effect on the human auditory cortex of removing specific frequencies from the acoustic environment. Subjects listened for 3 h on three consecutive days to music "notched" by removal of a narrow frequency band centered on 1 kHz. Immediately after listening to the notched music, the neural representation for a 1-kHz test stimulus centered on the notch was found to be significantly diminished compared to the neural representation for a 0.5-kHz control stimulus centered one octave below the region of notching. The diminished neural representation for 1 kHz reversed to baseline between the successive listening sessions. These results suggest that rapid changes can occur in the tuning of neurons in the adult human auditory cortex following manipulation of the acoustic environment. A dynamic form of neural plasticity may underlie the phenomenon observed here.

Acoustic Stimulation↗

PubMed1999

Cortical asymmetries of the human somatosensory hand representation in right- and left-handers.

Hemispheric asymmetry is known for higher brain functions like language and attention. We tested whether such an asymmetry also exists in the representation of elementary sensory functions. Magnetic source imaging was used to compare the cortical somatosensory hand representation in seven right- and five left-handed individuals. In all right-handers the representation of the dominant hand was larger than the contralateral one in the corresponding hemispheres. In contrast, only two out of five left-handers revealed a larger representation of the dominant left hand compared to the right one. In agreement with previous findings on the lateralization of language and attention, there is a strong correlation between handedness and the extent of the cortical hand representation in right-, but not in left-handers. We conclude that a profound functional hemispheric asymmetry also exists in primary sensory cortices.

Adult↗

PubMed1998

Dipole source localization by means of maximum likelihood estimation. II. Experimental evaluation.

A dipole source analysis of repeated measurements of the auditory evoked field (AEF) elicited by 60 dB SL tonebursts confirmed the previous theoretical prediction that a maximum likelihood estimation technique reduces localization errors resulting from noise in the measured data by about a factor of two as compared to the common least-squares fit procedure. To achieve a comparable improvement by averaging independent epochs (Gaussian noise assumed), the number of averages would have to be increased by a factor of 4. Conversely, the measurement time required to achieve a given localization accuracy could be reduced by that factor.

Adult↗

PubMed1998

Dipole source localization by means of maximum likelihood estimation I. Theory and simulations.

By analyzing simulated neuromagnetic recordings with a 37 channel magnetometer system, it was shown that the accuracy of a dipole source localization is considerably improved if the standard least-squares fit procedure is replaced by a maximum likelihood estimation accounting for the covariances of the noise in the measurement channels. Spatially correlated noise was generated by random dipoles homogeneously distributed in a sphere representing the brain. The study suggests that a maximum likelihood estimation reduces the standard deviations of the estimated dipole parameters by roughly a factor of two.

Algorithms↗