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Biomedical subjects

B Lagerlöf

Publications and source records attributed to B Lagerlöf.

At least 55 records · Page 3Linked to original sources
PubMed1977

Re-appraisal of malignant melanoma diagnosis in the Swedish cancer registry.

In many countries the registration of malignant melanoma of the skin shows an increased incidence; this may partially be due to an over-diagnosis. From the group of 3,268 adults and 21 children classified as suffering from malignant melanoma of the skin in the Swedish Cancer Registry between 1959-1968, a one-in-ten systematic sample survey was the object of a retrospective examination. 349 adults and 2 children had a uniform histopathological evaluation performed by one of the authors (B.L.). Slides were not available in 8 cases (2 per cent) and in the remaining 343, the diagnosis was regarded as incorrect in 13 (3.7 per cent). All these 13 cases, (2 children and 11 adults), showed no special predilection as to age, sex, location, or year of registration. In view of such a slight degree of error, the Swedish Cancer registry's melanoma group from 1959-1968 would seem suitable for further epidemiological studies.

Adolescent↗
PubMed1977

Malignant melanoma of the skin in children registered in the Swedish cancer registry during 1959-1971.

A clinical follow-up and histopathological reexamination of 26 cases originally diagnosed as malignant melanoma in children under 14 years of age registered in the Swedish Cancer Registry during 1959-1971 has been undertaken. Only one met current criteria of a malignant melanoma. This tumour occurred in a giant naevus in a 3-year-old girl, who died with widespread metastatic melanoma within a year. The other cases were reclassified as melanocytoma of Spitz, cellular blue naevus, compound naevus and neurofibroma. The results confirm that malignant melanoma is a rare tumour in prepubertal children. The risk for histophatological overdiagnosis is much higher in children (95%), than in adults (4%).

Adolescent↗
PubMed1976

Autopsy findings in leukaemia.

Out of 38 leukaemic cases only 16 had extensive leukaemic infiltration at death. 15 patients had slight or moderate and 7 no infiltration at all. 12 of the 15, and 5 of the 7 died with septicaemia. The latter patients must have died of complications rather than of the leukaemia itself. Although it has been possible to reduce the incidence of septicaemia during life, terminal septicaemia does not yet seem to be preventable. Septicaemia was revealed at autopsy in 27 of 38 patients; 25 of these also had clinical signs of septicaemia before death. Necrotizing gastrointestinal lesions may cause endogenous infection. In the present material, almost every second patient had fungal septicaemia. Out of 7 patients having oral candidiasis in vivo 5 had systemic candidiasis at autopsy, but only half of the patients with systemic candidiasis had visible oral growth. Modern treatment of leukaemia seems to be able to prevent intracranial haemorrhage in 90% of the cases. On the other hand, vacuolization of muscle and liver tissue was a frequent finding in leukaemia. It is suggested as being caused by fatty degeneration. Vacuolization of myocardial cells was found in 7 out of 13 cases. Among these 7, 4 had had intermittent hypokalaemia.

Acute Disease↗
PubMed1975

Alterations in erythropoiesis preceding leukemia.

An attempt was made to study preleukemic changes in bone marrow cell proliferation. Seven patients with hypercellular marrows and aregenerative anemia were studied. Five of them could be followed to autopsy, several years after the kinetic studies; all died with a picture of leukemia. Total bone marrow cell numbers, erythroblast generation times, and erythrocyte production were estimated with 59Fe. Despite hypercellularity, the total erythroblast number was not significantly increased. Erythrocyte production and life span were both decreased, and erythroblast generation time were significantly longer than normal.

Adult↗