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B Langner

Publications and source records attributed to B Langner.

13 recordsLinked to original sources
PubMed1999

Beyond correspondence, video conferencing, and voice mail: Internet-based master's degree courses in nursing.

The changing health care system and increasing demands for primary care providers have prompted an increase in nurse practitioner programs in the United States. Nurses in rural areas that are underserved by primary care practitioners often are faced with time and distance barriers to returning to school for advanced education. This article describes Internet-based courses as a unique distance learning platform for preparing primary care nurse practitioners at the University of Kansas (KU) School of Nursing. Discussion includes course development process, matching methods to course content, and other information on promoting interaction between students and faculty.

Curriculum↗
PubMed1998

Changes of renal taurine transport after treatment with triiodothyronine or dexamethasone in amino acid loaded rats.

In adult female anaesthetized rats, the influence of triiodothyronine or dexamethasone on renal amino acid (AA) handling was investigated in taurine (45 mg/100 g b.wt.) loaded animals. Bolus injections of taurine were followed by temporary increase in fractional excretion (FE(AA)) of taurine as well of the endogenous amino acids which were not administered. Under taurine load conditions, triiodothyronine treatment (20 microg/100 g b.wt. for 3 days, i.p. once daily) was followed by a slight stimulation of the renal taurine reabsorption: the increase in FE(taurine) after taurine load was lower than in untreated rats. Dexamethasone (60 microg/100 g b.wt. for 3 days, i.p. once daily) was without significant effect on FE(taurine) in taurine loaded rats. In non taurine loaded rats there was no hormone influence at all. Similarities and differences between the effects of bolus injections of taurine, glutamine, and leucine on the FE(AA) of these three amino acids were compared in detail to further clarify the reason for the increased amino acid reabsorption capacity after pretreatment with triiodothyronine or dexamethasone.

Amino Acids↗
PubMed1988

Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects.

Four subjects were synchronized with activity from 07 to 23 h and were given a single oral dose of 80 mg racemic propranolol at fixed times (08, 14, 20 and 02 h) at weekly intervals. ANOVA revealed significant circadian changes in the peak propranolol concentration (Cmax), with a maximum at 08 h and a minimum at 02 h after drug intake; tmax was not dependent on the circadian phase. The elimination half-life varied significantly with the time of day, being shortest at 08 h (3.3 h) and longest at 20 h (4.9 h). The stereospecificity of the propranolol pharmacokinetics was not dependent on the time of drug intake. No circadian variation was found in the maximum decrease in heart rate, but the time to peak effect was dependent on the time of drug intake; tmax was 2.3 h at 08 h and 7.0 h at 02 h. Thus, the time to peak drug concentration did not coincide with the time to peak effect on heart rate at different times of day. Circadian changes were also found in the systolic blood pressure and in the double product. The results show a significant daily variation in the pharmacokinetics and cardiovascular effects of propranolol. However, chronokinetics cannot explain the circadian changes in the effects of the drug. It is concluded that circadian variation in sympathetic tone and vascular reactivity is mainly responsible for the circadian changes in the effects of propranolol.

Administration, Oral↗
PubMed1986

Kinetic properties of the sodium bicarbonate (carbonate) symport in monkey kidney epithelial cells (BSC-1). Interactions between Na+, HCO-3, and pH.

BSC-1 kidney epithelial cells derived from the African green monkey are known to express a Na+HCO3- symport (Jentsch, T. J., Schill, B. S., Schwartz, P., Matthes, H., Keller, S. K., and Wiederholt, M. (1985) J. Biol. Chem. 260, 15554-15560). In the present work, 4,4-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)-sensitive 22Na+ uptake into confluent monolayers of BSC-1 is measured in the presence of ouabain (10(-4) M) and amiloride (10(-3) M) to define the interactions between Na+ and HCO3- binding and pH. Dependence of DIDS-sensitive 22Na+ fluxes on either Na+ or HCO3- can be described by Michaelis-Menten kinetics. External apparent Km for HCO3- decreases with increasing Na+ concentration (Km app (HCO3-) = 36 +/- 10, 18 +/- 5, and 9 +/- 3 mM at 20, 45, and 151 mM Na+o, respectively (pHo = 7.4)). Similarly, external apparent Km for Na+ decreases with increasing HCO3- concentration (Km app (Na+) = 73 +/- 22, 28 +/- 8, and 14 +/- 4 mM at 6, 17, and 56 mM HCO3o-, respectively (pHo = 7.4)). Vmax app remains constant within the experimental error. When data are replotted as a function of calculated NaCO3- concentration, they can be approximated by a single Michaelis-Menten equation. DIDS-sensitive uptake at constant Na+ and HCO3- displays a broad pH optimum in the range between 7.2 and 7.6. The data are compatible with the ion pair model in which the transported species, NaCO3-, binds to the transport site with Km = 15.3 +/- 4 microM. However, the data may also be fitted by either a random or ordered bireactant system. Sets of parameters necessary for these fits are given.

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid↗
PubMedDate not supplied

[Microalbuminuria in children and adolescents with and without Type-I diabetes mellitus (IDDM)].

In 73 healthy (group I) and 32 children and juveniles with insulin dependent diabetes mellitus (IDDM, group II) urinary albumin excretion is determined by radioimmunoassay (RIA). In both groups albumin excretion is observed in every urine sample when measured by RIA (mean +/- SD: group I: 7-19 h: 5.17 +/- 5.28 mg, 19-7 h: 3.86 +/- 4.00 mg, 24 h: 9.03 +/- 8.60 mg; group II: 7-19 h: 6.68 +/- 6.86 mg, 19-7 h: 3.46 +/- 2.82 mg, 24 h: 10.13 +/- 9.25 mg). No significant difference is detected between the values of the two groups. However in diabetic patients a significant difference is observed between diurnal and nocturnal urinary albumin excretion. Microalbuminuria is defined as an albumin excretion above 30 mg/d and is present in 6.9% of the values in group I and in 3.1% in group II. The physiological limits of microalbuminuria in children and juveniles compared to adults and several methods of urine sampling are discussed.

Adolescent↗
PubMedDate not supplied

[Comparative determination of microalbuminuria using radioimmunoassay and kinetic nephelometry in children and adolescent with and without Type-I diabetes mellitus (IDDM)].

In 73 healthy (group I) and 32 children and juveniles with insulin dependent diabetes mellitus (IDDM, group II) urinary albumin excretion is determined by radioimmunoassay (RIA) and kinetic nephelometry. Intention of the study is to examine, if the kinetic nephelometry is--as observed in adults--a suitable method also in children and juveniles to detect microalbuminuria (greater than 30 mg/d). In both groups albumin excretion is observed in every urine sample when measured by RIA. Because of it's higher threshold kinetic nephelometry detects albumin excretion only in a part of the urine samples. The correlation between the two methods is very high (r = 0.905, p less than 0.001, n = 174). So kinetic nephelometry is not suitable to determine reference values. But as a faster and possibly more specific method than RIA nephelometry is a very effective way for a screening of microalbuminuria also in children and juveniles.

Adolescent↗
PubMedDate not supplied

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Art↗
PubMedDate not supplied

[Results of the treatment of children with brain neoplasms. II. Quality of life].

In a group of 57 children with brain neoplasms with a long follow-up the authors assessed the neurological and somatic condition of these patients, as well as their mental development and social adaptation. It is suggested that a child completing successfully prolonged treatment (which includes in cases of malignant neoplasms also radiotherapy and chemotherapy) has a considerable likelihood of leading a relatively normal life. In most of these children the neurological deficit was absent or slight, and they could attend normal schools. The most frequent and most dangerous sequelae were vision disturbances (in about 12% of cases) due mainly to the site of the neoplasm. Attention is called also to growth disturbances as a result of radiotherapy. Another observed unfavourable consequence of radiotherapy is deterioration of intellectual abilities of the children, which was, however, usually at the level of slight mental retardation.

Adaptation, Psychological↗