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Biomedical subjects

B Laursen

Publications and source records attributed to B Laursen.

At least 19 recordsLinked to original sources
PubMed1992

[The post-thrombotic syndrome. A review].

The post-thrombotic syndrome which is caused by deep venous thrombosis and characterized by pain, oedema, pigmentation, eczema, lipodermatosis, varices and ulceration, is due to deficient function of the venous valves and/or obstruction of the deep veins with venous hypertension. The diagnosis may be established by investigation of the investigation of the muscular-venous pump by pletysmography or dynamic phlebography and invasive measurement of the venous pressure is not employed to any great extent. The results of valvuloplasty have, by and large, been negative. The main form of treatment is, therefore, conservative compressive bandaging which can reduce the symptoms, facilitate healing of venous ulcers and prevent recurrence of ulcers. It is emphasized, however, that this treatment must be continued consequently during the remainder of the patient's life, regardless of other treatment.

Humans↗
PubMed1992

[The post-thrombotic syndrome. Description and comparison of diagnostic methods: clinical examination, venous return time, phlebography and ultrasonography].

Thirty-one patients with deep vein thrombosis (DVT) confirmed by phlebography 5-11 years previously were examined for the post-thrombotic syndrome (PTS). Where all of the patients were concerned, the examination included crossing-off of their symptoms of PTS on a special chart and clinical examination carried out by four doctors independently of one another, for 29 patients also determination of the venous return time by strain gauge pletysmography and for 29 patients also secondary phlebography (SF) and B-method ultrasonic scanning (UL). The degree of severity of PTS was determined by means of a scoring value which was calculated on the bases of four observers assessment of the clinical symptoms and findings. Significant differences were found for the clinical scores for legs with and without previous DVT, which shows that the method is of value despite a not inconsiderable interobserver variation. In the form employed here, pletysmography was found unsuitable for quantitating of PTS. In 60% of the patients, agreement was present between the clinical assessment, SF and UL. The necessity of agreement both as regards the diagnostic clinical criteria and as a measure for the degree of severity of PTS is emphasized. UL is recommended as a screening investigation for changes after DVT. Phlebography is only considered to be indicated in cases where detailed knowledge of the anatomical conditions is desired e.g. prior to venous surgery.

Adult↗
PubMed1991

[Standardized prothrombin time determinations and optimal anticoagulant therapy].

WHO and other international organizations have recommended the introduction of a standardized prothrombin time determination. This would allow a universal scale for the intensity of oral anticoagulation therapy to be used. A prerequisite is the use of thromboplastin, calibrated against the international reference thromboplastin, standardized methodology etc. This permits every prothrombin time determination to be expressed as International Normalized Ratio (INR). The introduction of INR facilitates the implementation of optimal oral anticoagulation as defined by larged international studies.

Anticoagulants↗
PubMed1991

Bias and random errors in historical data of exposure to organic solvents.

The biases and random errors in data from industrial hygiene measurements have been evaluated. Such data are often used for exposure assessment in epidemiologic studies by people who are not professional industrial hygienists. The quality of such data is, therefore, of paramount importance. Data sets from two investigations of the exposure to organic solvents in the same industry have been analyzed. The study shows that the errors and analysis of field samples are larger than errors determined from laboratory data but smaller than errors from other sources. One exception, in which laboratory errors are large, is when data originate from different ways of determining recovery. Very large biases may arise for certain combinations of analytes and extraction liquid when the "equilibrium method" is used. The data sets from the two investigations had a bias, which was as large as a factor of 5 to 10. This bias is believed to be caused by use of two different sampling strategies. In all industrial hygiene data, large random errors are embedded because of day-to-day variations in exposure levels; therefore, the data are mostly used grouped into three classes of low, medium, and high exposure. To do so is meaningful, as a large amount of data will compensate for misclassifications. But a large amount of data cannot compensate for the bias introduced when merging data generated under different sampling strategies. Data describing the same object, but originating from different sampling strategies, should not be pooled without proper tests, which show that data are comparable.(ABSTRACT TRUNCATED AT 250 WORDS)

Bias↗
PubMed1988

Pattern of immunoglobulin classes and IgG subclasses of platelet-associated immunoglobulin in HIV-seropositive haemophiliacs.

Abnormal amounts of platelet-associated immunoglobulins (PAIg) and seropositivity for HIV were demonstrated in 18 haemophiliacs suffering from thrombocytopenia of varying severity. Among 34 non-thrombocytopenic haemophiliacs seropositivity for HIV was found in association with increased levels of PAIg in 18 patients, whereas increased amounts of PAIg were seen only in 4 of the 16 patients seronegative for HIV. In most of the haemophiliacs with thrombocytopenia, the PAIg represented all classes of immunoglobulins and in half of the cases all subclasses of IgG, while in 33 patients with autoimmune thrombocytopenic purpura (AITP), PAIg was IgG1 and IgM in most cases. Our data show a difference in the pattern of PAIg in AITP patients and in thrombocytopenic haemophiliacs seropositive for HIV. We suggest that the thrombocytopenia in haemophiliacs is related to the polyclonal B cell activation also found in other patients seropositive for HIV and perhaps indicative of AIDS-related complex.

Blood Platelets↗
PubMed1988

Conflict and the friendship relations of young children.

The purpose of this investigation was to compare conflicts occurring between young children and their friends to those occurring between nonfriends. 53 children with a median age of 4 years, 3 months were observed and interviewed to determine who were mutual friends, unilateral associates, or neutral associates. 146 conflicts were also observed. Conflicts between mutual friends, as compared to those occurring between neutral associates: (a) did not occur less frequently, differ in length, or differ in the situations that instigated them, but (b) were less intense, were resolved more frequently with disengagement, and more frequently resulted in equal or partially equal outcomes. Continued socialization was also more likely following conflicts between friends. Conflicts between unilateral associates resembled those between nonfriends, although postconflict interaction resembled that between mutual friends. Conflict resolution strategies favored by friends maximize the likelihood that their interaction and their relationships will continue.

Aggression↗
PubMed1985

Yersinia enterocolitica infection complicated by severe thrombocytopenia resistant to high-dose intravenous immunoglobulin.

A young female patient developed severe thrombocytopenia 10 days after an infection with Yersinia enterocolitica, serotype 3. She was treated with high-dose intravenous immunoglobulin without effect, and later corticosteroids also failed to induce remission. After 10 days of profuse bleeding the platelet count rose slowly to normal. Her tissue type was HLA-B27. To our knowledge, thrombocytopenia complicating Yersinia infection has not been reported before.

Adolescent↗
PubMed1985

Phase III study of intermittent 5-drug regimen (VBCMP) versus intermittent 3-drug regimen (VMP) versus intermittent melphalan and prednisone (MP) in myelomatosis.

A prospective randomized trial in 96 patients with previously untreated myelomatosis was performed comparing 3 regimens of chemotherapy: (i) Intermittent vincristine, BCNU, cyclophosphamide, melphalan, and prednisone (VBCMP) to (ii) intermittent vincristine, melphalan and prednisone (VMP) to (iii) intermittent melphalan and prednisone (MP). Induction response rates and survival were similar in all 3 regimens. An improvement in relapse-free survival was observed by adding vincristine to MP, but this did not achieve statistical difference (p = 0.10). Patients given VBCMP fared slightly worse than those given VMP. The haematologic toxicity was similar in all 3 regimens, but the tolerability of VBCMP was lower. Although showing no statistical differences between the 3 treatment regimens, the results support the view that a combination of MP 'standard' induction therapy in MM with frequently administered vincristine has a trend towards postponing treatment failure due to development of resistance to melphalan.

Adult↗
PubMed1978

Post-transfusion purpura treated with plasma exchange by haemonetics cell separator. A case report.

A case of post-transfusion purpura in a 61-year-old, multiparous female with a platelet alloantibody (anti-Zwa) in her serum is reported. The patient was successfully treated with plasma exchange by means of a Haemonetics 30 cell separator and corticosteroids. Compared with other therapeutic measures, plasma exchange seems to shorten the duration of thrombocytopenia. Major surgery was possible in our patient within ten days of development of the syndrome.

Appendectomy↗
PubMed1977

Mixed lymphocyte culture responses in infertile couples.

Twenty couples suffering from unexplained infertility have been tested in mixed leucocyte culture to determine if the wives were preimmunized against their husbands. The wives were tested against their husbands and four unrelated persons, and thymidine incorporation was measured on the third and fifth days of culture. No evidence was found that would indicate a preimmunization of the wife against her husband as an explanation for their infertility. A slight MLC stimulatory capacity was found in sera from infertile women.

Culture Media↗