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Biomedical subjects

B Lederer

Publications and source records attributed to B Lederer.

32 records · Page 2Linked to original sources
PubMed1975

[Lactacidaemia and disseminated intravascular coagulation associated with phenformin medication (author's transl)].

A patient with chronic active hepatitis developed vomiting, dyspnoea, tachycardia, diarrhoea and diffuse pains. For several years she had been treated with azathioprine and for a few weeks before admission with phenformin for mild diabetes. Laboratory examination revealed acute disseminated intravascular coagulation and lactacidaemia. Despite intensive treatment the patient died a few hours after admission, the post-mortem examination revealing diffuse pulmonary haemorrhages. The present case report and those published in the literature suggest that phenformin should not be given to diabetics who also have renal or hepatic disease. In any case, if phenformin is given, it should be stopped if hepatic, renal, infectious or thrombotic complications occur. In these cases and those of sudden unexplained deterioration in diabetics, hospitalisation is essential and lactic acid levels should be determined and coagulation tests performed.

Acidosis↗
PubMed1975

[Quantitative Cytochemical and Morphometric Investigations on Uterine Angiomatosis (Endolymphatis Stromal Myosis) and Stromal Sarcoma].

The angiomatosis uteri shows a low scattering of nuclear DNA content; an euploid DNA stem line suggests a benign behavior in these tumors. This evidence is supported by clinical experiences. The endometrial stromal sarcoma and the angioblastic sarcoma are characterized by a high scattering of nuclear DNA content, an aneuploid DNA stemline and a substantial irregularity of the nuclear area. These difference, suggest the malignancy of stromal and angioblastic sarcoma.

Adult↗
PubMed1975

Glycogen phosphorylase and its converter enzymes in haemolysates of normal human subjects and of patients with type VI glycogen-storage disease. A study of phosphorylase kinase deficiency.

1. The properties of phosphorylase a, phosphorylase b, phosphorylase kinase and phosphorylase phosphatase present in a human haemolysate were investigated. The two forms of phosphorylase have the same affinity for glucose 1-phosphate but greatly differ in Vmax. Phosphorylase b is only partially stimulated by AMP, since, in the presence of the nucleotide, it is about tenfold less active than phosphorylase a. In a fresh human haemolysate phosphorylase is mostly in the b form; it is converted into phosphorylase a by incubation at 20degreesC, and this reaction is stimulated by glycogen and cyclic AMP. Once activated, the enzyme can be inactivated after filtration of the haemolysate on Sephadex G-25. This inactivation is stimulated by caffeine and glucose and inhibited by AMP and fluoride. The phosphorylase kinase present in the haemolysate can also be measured by the rate of activation of added muscle phosphorylase b, on addition of ATP and Mg2+. 2. The activity of phosphorylase kinase was measured in haemolysates obtained from a series of patients who had been classified as suffering from type VI glycogenosis. In nine patients, all boys, an almost complete deficiency of phosphorylase kinase was observed in the haemolysate and, when it could be assayed, in the liver. A residual activity, about 20% of normal, was found in the leucocyte fraction, whereas the enzyme activity was normal in the muscle. These patients suffer from the sex-linked phosphorylase kinase deficiency previously described by others. Two pairs of siblings, each time brother and sister, displayed a partial deficiency of phosphorylase kinase in the haemolysate and leucocytes and an almost complete deficiency in the liver. This is considered as being the autosomal form of phosphorylase kinase deficiency. Other patients were characterized by a low activity of total (a+b) phosphorylase and a normal or high activity of phosphorylase kinase in their haemolysate.

Adenosine Monophosphate↗
PubMed1975

[Different maturation of leukemic blasts in tumor--like type of acute infantile leukemia (author's transl)].

In condition, it has been found that an acute infantile leukemia in its early stages, manifested itself clinically and morphologically as a reticulosarcome. Through cytochemical examinations, the malignant disease could be identified as an acute myeloid leukemia. The blasts in the tumourous tissues show less differentiation than the leukemic blood and bone marrow cells. The lack of maturation of the blasts is discussed as the cause of tumorlike cell growth.

Bone Marrow Cells↗
PubMedDate not supplied

[Cancer of the female sex organs in Baranja: 1985-1990].

Over a 6-year-period (January 1, 1985 to December 31, 1990) 86 women with cancer of genital organs were detected in the region of Baranya. According to the census of the year 1981, 27416 women have lived in Baranya, and in the above mentioned period 23533 examinations were done at the Women Welfare Clinic of the Health Centre Beli Manastir. In the period from 1985 to 1989, the average frequency of cervical cancer was 63.1%, uterine corpus cancer followed with 19.7%, ovarian and tubal with 13.1%, vulvar with 2.6% and vaginal with 1.3%. In the period from January 1 to December 31, 1990, cervical cancer accounted for 45.4% of all cancer cases, corpus cancer for 27.2%, ovarian and tubal cancer for 18.1%, without detection of any vulvar or vaginal cancer cases. In the observed period mean annual incidence of genital cancer was 52.9 per 100,000. According to organ sites mean annual incidence of cervical cancer was 32.1, corpus cancer 10.9, ovarian and tubal cancer 7.3, vulvar 1.2 and vaginal cancer 0.7 per 100,000. During the six year period cervical cancer incidence was reduced from 43.8 in 1985 to 18.2 per 100,000 in 1990. Corpus cancer incidence in 1985 was 14.6 as compared to 10.9 in 1990. Ovarian and tubal cancer incidence in 1985 and 1990 was 10.9 and 7.3, respectively. In the observed period preinvasive lesions of genital organs were discovered in 208 women, 201 (96.6%) of whom had cervical lesions--mean incidence here is 122.2 per 100,000. The overall proportion of preinvasive to invasive cervical lesions in the observed period was 79.1% to 20.9%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Atypical cervical cytology during pregnancy in the region of Baranja].

In the period from 1985 to 1989, 2521 pregnant women, making up 18.7% of women in fertile age, were controlled in antenatal surgeries in the area of Baranja. In 73 (2.9%) women a cytologic picture of cervical atypia was found: in 2.1% of them there was a cytologic picture of light and moderate dysplasia (group IIIA), in 0.6% a picture of severe dysplasia (group IIIB), and in 0.2% pregnant women there was a picture of carcinoma in situ (group IV). Progression of cytologic findings into a higher stage was noted in 23.3% women, persistence was recorded in 21.9% and regression in 54.8% women. A total of 71.2% pregnant women with the cytologic atypia of the cervix were colposcopically examined. An abnormal colposcopic picture was found in 65.4% of them. By the end of the puerperium histologic verification was made in 38.4% cases and 61.6% were controlled only cytologically and colposcopically. By means of histologic examination of the tissue specimen, progression of an intraepithelial lesion into an invasive carcinoma was not found in any of the women. These results corroborate the point of view that in pregnant women with the cytologic atypia of the uterine cervix the histologic verification can be postponed until after the delivery without any considerable risk. Only in the case of a cytologic or colposcopic suspicion of invasion it is necessary to verify the finding histologically.

Female↗
PubMedDate not supplied

[Characteristics of cancer of the female reproductive organs as observed at the Gynecology-Obstetrical Department of the Osijek General Hospital].

In the 1980-1989 period, 671 women were diagnosed with a malignant tumour of reproductive organs at the Department of Gynaecology, Cervical cancer proved most frequent, with 46.5% of the cases, followed by the cancer of the uterine body occurring in 29.5% of the patients. In 18.8% of the women, ovarian and oviductal cancer was diagnosed, whereas vulvar and vaginal cancer was found in 5.5% of the cases. There were 76.1% of the patients older than 50 years. Nulliparas suffered from ovarian and uterine body cancer significantly more often than from cervical cancer (t = 3.794; p less than 0.001, i.e. t = 2.974; p less than 0.001). However, terti- or multiparas had cervical cancer significantly more often than the cancer of ovaries or the uterine body (t = 3.711; p less than 0.001, i.e. t = 3.000; p less than 0.01). The first stage ovarian cancer was diagnosed in 15.0% of women only, whereas 37.1% of cervical and 78.3% of uterine body cancers were discovered at the first stage. At the time of diagnosis, the mean age of the patients with cervical cancer was 55.8 years, with ovarian cancer 57.9 years, with oviductal cancer 57.3 years, with uterine body cancer 60.8 years and with vulvar cancer 71.7 years. There were 34% of cervical cancer patients at the premenopausal age 15.5% with uterine body cancer and 27.5% of those suffering from ovarian cancer. The general five-year survival rate for patients suffering from the cancer of reproductive organs was 40.6%, i.e. 40.5% for cervical cancer, 54.7% for uterine body cancer, 23.4% for ovarian and oviductal cancer and 17.7% for vulvar or vaginal cancer. The total of 25% of the patients were lost from the evidence.

Adult↗
PubMedDate not supplied

[Bacteriological analysis of the cervical canal in uterine cervix insufficiency].

A bacteriological analysis was made of pyogenic agents from the cervical canal of 260 pregnant women with cervical incompetency, in whom the cerclage of the cervix was performed. Pyogenic agents were found in 139 (53.5%) pregnancies. The most frequently isolated pathogenic agent was Enterococcus--in 19.2% of all pregnant women and in 36.0% in those with a pathologic swab. E. coli was isolated in 16.5% of all pregnant women and in 30.9% of those with the pathologic swab. A significantly higher number of pathologic swabs were found in women with colpitis and the cleanliness 3 degree of the vaginal discharge and without colpitis (6.4%). In pregnant women with a pathologic swab, in spite of the cervical cerclage, spontaneous abortions and premature deliveries were significantly more frequent (8.2% and 16.4% respectively) than in pregnant women with a sterile swab (1.8% and 6.1% respectively).

Bacteria↗