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Biomedical subjects

B Leibundgut

Publications and source records attributed to B Leibundgut.

9 recordsLinked to original sources
PubMed1992

Long-term results of varicocelectomy.

Between 1983 and 1985, 257 infertile men were examined for any present varicocele by means of the Doppler sonography, telethermography and palpation. Based on these findings, the spermiogram and the infertility history, high ligation of the spermatic vein was indicated in 89 patients with varicocele and a median duration of infertility of 36 months (6-88 months). Postoperative sperm examinations have shown a significant improvement in sperm count and morphology, but not in motility. The most significant drop was observed in germ cell concentration from 1.68 to 1.06 mio/ml (p less than 0.025 Wilcoxon signed rank sum test). The follow-up examination 6 years after the beginning of the study has shown that only 56 out of the 89 patients underwent surgery, whereas 33 patients refrained from it. Pregnancy rates were 42% (23 out of 55, 1 patient lost to follow-up) in the operated group and 45% (14 out of 31, 2 patients lost to follow-up) in the nonoperated group. The comparison of the two graphs showing pregnancy incidence clearly demonstrates that pregnancies in the nonoperated group occur earlier than in the operated group; it has to be noted, however, that several patients only refrained from being operated on because pregnancy had occurred before surgery was planned. On the one hand, our study confirms other authors' results, i.e. that pregnancy rates in the nonoperated group are relatively high despite present varicocele. On the other hand, the operated group achieved practically the same high pregnancy rate when monitored over a longer period of time.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗
PubMed1991

[Initial experiences with prostaglandin E1 and PGE1 prepared injections].

Between April and August 1989 we treated 50 patients with an erectile dysfunction. 23 patients (46%) had an organic, 17 (34%) a psychogenic and 7 patients (14%) a mixed origin of their impotence. In 3 patients the diagnosis has yet to be made. To induce pharmacological erections we used 20 micrograms of prostaglandin-E1 in a ready to use syringe. 64% (32 patients) achieved a full erection. Of the 18 patients insufficiently responding, 12 (67%) had an organic (in 11 patients vascular), 4 a psychogenic and 1 patient a mixed erectile dysfunction. In one patient the diagnosis has not been established at present. 14% (7) of the patients complained to have painful erections disturbing intercourse. The mean erection time was 2.5 hours (range 0.5-5.5). In one patient the intracavernous injection of prostaglandin-E1 resulted in a prolonged erection of more than seven hours, which was successfully treated by aspiration of blood from the corpora cavernosa and intracavernous injection of phenylephrine-hydrochloride. Nevertheless prostaglandin-E1 appears to be more physiological and to have less side-effects than papaverin-chloride.

Alprostadil↗
PubMed1985

Blot-immunobinding test for the detection of anti-sperm antibodies.

A blot-immunobinding test was used to detect anti-sperm antibodies in human sera and to identify the corresponding auto- or iso-antigens on human sperm. A high proportion of sera at a 1:100 dilution from fertile persons, as well as infertile patients, contains antibodies reactive with sperm. This phenomenon might be physiological. At 1:2,000 dilution, a higher binding capacity was detected in the sera from infertile groups, but a few fertile persons were also positive. Antibodies to a single antigenic determinant with Mr of approximately 14,000 were found in a significantly higher proportion among males with unexplained infertility.

Antibodies↗
PubMed1979

[Value of the meiosis test in male infertility].

The histological evaluation of testicular biopsy in the investigation of infertility was supplemented by cytogenetic analysis of spermatogenesis in 72 patients from 1976--1978. The results show meiosis analysis to be a practical aid in the assessment of male infertility. It enables the point of interruption in the meiotic process to be accurately identified. A review of relative populations of meiotic and of interphase nuclei (the meiotic index) permits evaluation of a quantitative disturbance of spermatogenesis, a finding that is of particular value when establishing a patient's prognosis. Moreover, meiotic analysis makes it possible to recognize cytogenetic anomalies which could be responsible for the infertility state and which were chiefly seen in patients whose so-called primary infertility was hitherto classified as being of unknown origin. In two patients we thus identified a small additional chromosome in a fraction of the germinal cells, and also an abnormal pairing of all chromosomes, or the sex chromosomes alone, during the first meiotic division.

Biopsy↗
PubMed1979

[Long-term observations on different methods of nephropexy].

In 29 patients with nephroptosis two different methods of nephropexy were compared; nephropexy using sutures passing through the parenchyma (n = 16) and nephropexy using tissue adhesives (n = 13). The first group was mobilized 3.5 days after operation, whereas the second group was mobilized one day after operation. On later follow-up 79% of the patients had no or minor complaints. Those patients who had the same disturbances as preoperatively had all been treated by nephropexy using sutures passing through the parenchyma. In 56% of this group radiological recurrence was seen, whereas in the group using tissue adhesives there was only 8% radiological recurrence. We think therefore that the nephroxepy using tissue adhesive is the simplest and least traumatic method.

Adult↗
PubMed1979

[Rectosigmoidovesical fistula].

The symptomatology of vesico-colonic fistulae is presented and their differential diagnosis discussed. Management should be tailored to the individual case. Whenever possible, we perform a radical primary operation. An additional by-pass colostomy is indicated if it is felt that the integrity of the anastomosis is jeopardised.

Colon, Sigmoid↗
PubMed1977

Rectal bladder with dorsolateral, intrasphincteric submucosal pul through of the sigmoid colon in adult bladder cancer patients. Five years later.

Report on 12 adult bladder tumor patients with cystectomy, rectal bladder and dorsolateral, intrasphincteric pull through of the sigmoid and anal colostomy (Nédélec type). Voluntary control of feces and urine was found satisfactory by most patients although urinary continence at night was not perfect. The long-term prognosis with this form of urinary diversion in patients with bladder cancer was far from satisfactory: 4 patients died of recurrent carcinoma with terminal symptoms of sepsis, but 5 patients died from primary sepsis (and not cancer) from 3 months to 4 years after diversion. It seems that this bad prognosis was due to insufficient separation of urinary and fecal passage in a group of patients, where the upper urinary tract has often already suffered as the result of earlier tumor treatment. Fewer complications might be expected with an intersphincteric pull through and perineal colostomy (Gersuny type).

Aged↗