Biomedical subjects

B Lerner

Publications and source records attributed to B Lerner.

11 recordsLinked to original sources

PubMed1987

Diabetic retinopathy: recommendations for primary care management.

Diabetic retinopathy is a major cause of vision loss in the elderly, yet it is questionable whether sufficient cases are being diagnosed promptly enough for optimal therapy. The authors summarize the salient features in the development and progression of diabetic retinopathy, review the effectiveness of therapy, and discuss physician performance in conveying this therapy to diabetic patients. The authors emphasize the role of primary care in the referral of these patients.

Aged↗

PubMed1983

[ECT in our time].

Explore the source record for details and available documents.

Electroconvulsive Therapy↗

PubMed1977

Inactivation of bacterial D-amino acid transaminase by beta-chloro-D-alanine.

Purified D-amino acid transaminase from Bacillus sphaericus catalyzes an alpha,beta elimination from the D isomer of beta-chloroalanine to yield equivalent amounts of pyruvate, chloride, and ammonia; the L isomer of chloroalanine is not a substrate for this transaminase. During the beta elimination there is a synchronous loss in enzyme activity; the Kinact for beta-chloroalanine was estimated to be about 10 micrometers. The alpha-aminoacrylate-Schiff base intermediate formed after beta elimination of chloride ion is probably the key intermediate that partitions between one inactivation event for every 1500 turnovers. In the presence of D-alanine and alpha-ketoglutarate, which are good substrates for the transaminase activity of this enzyme, beta-chloroalanine is a potent, competitive inhibitor (K1 = 10 micrometers) with D-alanine and a weak, uncompetitive inhibitor with alpha-ketoglutarate.

Alanine↗

PubMed1973