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Biomedical subjects

B Liebgott

Publications and source records attributed to B Liebgott.

8 recordsLinked to original sources
PubMed1989

Fetal toxicity caused by excessive maternal dietary calcium.

The effects of diet-induced maternal hypercalcemia on fetal development were studied in the CD 1 mouse. Female mice were maintained for two weeks on high calcium diets and then mated. The resulting litters were surgically removed one day prior to term and compared to control litters of untreated mice. Fetuses from the treated litters showed significantly lower birth weights and higher frequencies of missing calcification centres in the developing skeletons and dentitions. In addition, centres that had begun to calcify were not as advanced as corresponding centres in the control series. It appears that high calcium intake during pregnancy is fetotoxic and results in decreased fetal weight and retarded skeletal and dental calcification.

Animals↗
PubMed1985

Prenatal hamster development following maternal administration of PGE2 at midterm.

The effects of PGE2 on embryonic and fetal development were studied in the golden Syrian hamster. Pregnant hamsters were treated on day 8 of gestation with either 0.2, 0.5, 0.75, or 1.0 mg/kg PGE2 delivered I.P. and the near term litters were compared to those of untreated and vehicle treated controls. Fetuses from the treated litters showed significantly higher frequencies of mortality, lower weights, malformations, and missing ossification centres in comparison to control litters. The results demonstrate that PGE2 is teratogenic in the hamster and the developing neural tube and the fetal skeleton are particularly susceptible to the effects of this teratogen.

Abnormalities, Drug-Induced↗
PubMed1977

Factors of human skeletal craniofacial morphology.

Thirty cephalometric measurements representing craniofacial depth, height, and width were obtained from lateral and posterior rediographs of 66 boys, 8 years of age. A multivariate factor analysis was performed on these measurements in an effort to locate specific areas of variability within the craniofacial complex. Twelve uncorrelated factors were extracted which account for 91% of the total variance and these were identified as: 1) retrognathic facial type, 2) anterior dentoalveolar height, 3) maxillary body length, 4) cranial base and facial width, 5) mandibular ramus height, 6) anterior maxillary body height, 7) mandibular length, 8) cranial vault height, 9) vertical position of the condyles, 10) cranial vault and clivus length, 11) bigonial width, and 12) cranial vault width.

Adolescent↗