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Biomedical subjects

B Liliequist

Publications and source records attributed to B Liliequist.

At least 19 recordsLinked to original sources

Assessment of posterior fossa tumors in infants and children by means of computed tomography.

The attenuation profiles before and after contrast enhancement were examined in 18 infants and children with posterior fossa tumors: eight cerebellar astrocytomas, six medulloblastomas, and four brainstem tumors. The astrocytomas, with one exception, had characteristic patterns, and all could be distinguished from the medulloblastomas, which have a distinct pattern of their own. The brainstem tumors had varying appearances, and were entirely low-attenuating, high-attenuating or had a ring shadow after enhancement. The nature of a posterior fossa tumor in a pediatric patient can usually be predicted fairly satisfactorily from a computed tomogram.

Adolescent

Spontaneous thrombosis of ruptured intracranial aneurysms during treatment with tranexamic acid (AMCA). Report of three cases.

Radiographically verified spontaneous disappearance of medium-sized arterial cerebral aneurysms is seldom reported, and only three times in connection with antifibrinolytic therapy (EACA). In our clinic repeat angiograms have shown non-filling of the aneurysms in three patients during treatment with tranexamic acid (AMCA) two, three, and four weeks respectively after primary bleeds. Initially, all three patients had severe radiological vasospasm associated with neurological deterioration. Follow-up angiograms have demonstrated partial reappearance of the aneurysm after one month in one patient and complete disappearance of the aneurysms in the other two patients after 9 and 22 months respectively. In two cases occlusion of cerebral arteries occurred. With regard to the higher risk of severe vasospasm and occlusion of cerebral arteries in our opinion it should not be a therapeutic goal to try to achieve a thrombosis of a ruptured aneurysm with antifibrinolytic drugs. The reason for spontaneous aneurysm thrombosis during treatment with AMCA may be a local inhibition of plasminogen activators in and around the aneurysm wall. It may also be related to the sympathomimetic property of the drug, with vasospasm and a subsequent flow-reduction inside the aneurysm or a possible interaction with other drugs and substances.

Adult

Bone mineral content in the proximal tibia measured by computer tomography.

With a slight modification of the EMI MK1 scanner a sensitive method for examination of the bone mineral content in the proximal tibia was achieved. The method allows an estimation of the amount of trabecular and cortical bone as well as their mineral content. The anatomic structure of the bone substance is demonstrated, differing in osteoporosis and osteomalacia. The reproducibility is acceptable.

Bone and Bones

Quantitative estimation of tumor volume on computer assisted tomography.

With the use of computer assisted tomography (CAT), the volume of intracranial hemorrhages can be calculated. The present work outlines a method that, based on EMI scan printouts, makes possible a calculation of the volume of hemorrhages, tumors, or other pathological changes detectable on CAT with a high degree of accuracy, even when the pathological changes are irregular in shape. Thus, there have been divergences between the estimations of volume of meningiomas using this method and the measure of the volume of the enucleated meningiomas within the range of 0 to +5%. An example of such a meningioma, and the calculation of its volume, is presented.

Brain

Computed tomography of the paranasal sinuses.

The diagnostic value of computer tomography in lesions of the paranasal sinuses has been investigated in three cases with maxillary carcinoma and in five cases with fractures of the facial bones. In most of the cases, particularly in carcinoma, computer tomography was found to provide additional information to that obtained with conventional X-ray techniques. In fractures, however, a supplementary plain film examination was found to be indispensable.

Facial Injuries

Cerebral aneurysm in an infant with fibromuscular hyperplasia of the renal arteries. Case report.

The authors report a case of subarachnoid hemorrhage in an 11-month-old infant with tragic outcome. Radiological investigation showed an anterior communicating aneurysm, and postmortem examination confirmed the aneurysm to be a so-called "berry" aneurysm. There were also typical signs of fibromuscular hyperplasia of the renal arteries. The microscopic findings are discussed. In view of the rarity of both aneurysms and fibromuscular hyperplasia in such a small child, a possible association of these entities suggested by several earlier investigators is reviewed.

Arterial Occlusive Diseases

Giant serpentine intracranial aneurysm after carotid ligation. Case report.

A case is reported of a giant aneursym of the intracavernous portion of the left internal carotid artery that was treated initially with a left common carotid artery ligation. Six months later the aneurysm was partially removed. During this time the development and evolution of thrombus formation, a serpentine channel, and a hypervascular capsule was easily followed with recreated computerized tomography and angiography of the aneurysm.

Adult

Tranexamic acid in the preoperative management of ruptured intracranial aneurysms.

A randomized, controlled clinical trial was carried out to study the effect of tranexamic acid (AMCA, trans-AMCHA) in prevention of early rebleeding after proven rupture of an intracranial aneurysm. The series comprises 46 patients admitted to the hospital within three days after the first bleeding. Twenty-three were treated with tranexamic acid and 23 were controls. Nine patients in the control group and one in the group treated with tranexamic acid had confirmed rebleeding. The incidence of vasospasm, cerebral ischemia and hydrocephalus as well as mortality and morbidity is discussed.

Adult

Computed tomography and subarachnoid hemorrhage.

CT scans have been made on 39 of 41 patients who presented with subarachnoid hemorrhage. Blood could be visualized in the cisterns of 18 of 32 examinations performed within five days of the hemorrhage all having aneurysms. Among the other 14 there were three in whom no aneurysm was found on angiography. The distribution of blood in those that showed it was useful in pointing to the position of the aneurysm. Much other information was obtained, for instance about rebleeding and infarction. CT should routinely be the primary examination, followed by selective angiography.

Adult

Absent cervical pedicle.

Congenital defect of a cervical pedicle produces a rare clinical syndrome with a characteristic X-ray picture associated with vague clinical signs often accentuated after trauma. A careful analysis of the X-ray films, including oblique views, shows the congenital defect of the pedicle and the associated abnormalities which can all be attributed to a defect in the neural arch centre of chondrification. Further X-ray examinations including myelography with or without vertebral angiography as well as surgical exploration should be unnecessary. A case of absence of the right pedicle of the sixth cervical vertebra is described. The symptoms in this patient were not caused by the malformation, but by an associated enlarged seventh cervical transverse process which produced a thoracic outlet syndrome.

Adolescent

Spinal cord angiomas diagnosed by gas myelography.

Three cases with spinal cord arteriovenous malformations are reported with characteristic changes evident on gas myelography. The malformations were confirmed by selective spinal angiography in all cases and surgically removed in 2 of the cases.

Aged

Rupture of intracranial aneurysm during carotid angiography.

The reports of rupture of an aneurysm during carotid angiography are very few but the actual incidence is doubtless higher than recorded. The case presented is documented with the demonstration of a large middle cerebral artery aneurysm with an intratemporal hematoma, and, in sequence, the rupture of the aneurysm during the height of the injection and the subsequent extensive leakage of the contrast medium. The factors which can lead to rupture of an aneurysm during the angiographic procedure are discussed.

Cerebral Angiography

Traumatic lateral sinus thrombosis. Report of two cases.

Two cases with thrombosis of the transverse sinus caused by a fracture crossing the sinus are reported, and the roentgenological changes seen in cerebral angiography are discussed. In 1 case, a filling defect was seen which at subsequent autopsy was found to correspond with an intraluminal thrombosis. In the other case, not verified at autopsy, the angiographic changes were consistent with a thrombosis of a transverse sinus.

Aged

Preliminary experiences with the EMI scanner.

Preliminary experiences of computed tomography of the head are reported in a material of 213 patients. The majority of examined lesions includes intracranial tumours and cerebrovascular lesions.

Arachnoid