Antiviral activity of glycyrrhizic acid.
Glycyrrhizic acid inhibits the growth of several DNA and RNA viruses in cell cultures and inactivates Herpes simplex 1 virus irreversibly.
Cells, Cultured↗
Biomedical subjects
B Loddo
Publications and source records attributed to B Loddo.
Development of drug resistance and dependence in viruses.
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Antiviral Agents↗
Glycyrrhizic acid inhibits virus growth and inactivates virus particles.
Screening investigations in antiviral action of plant extracts have revealed that a component of Glycyrrhiza glabra roots, found to be glycyrrhizie acid, is active against viruses. We report here that this drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.
Antiviral Agents↗
Dichloropyrimidines: specific inhibitors of virus growth.
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Antiviral Agents↗
Enhancement of virus growth produced by thiols and disulphides.
Several thiols and disulphides have been found able both to shorten the latency phase and to increase the growth of several virus strains in cell cultures.
Disulfides↗
Specific inhibition of virus multiplication by bichlorinated pyrimidines.
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Drug Synergism↗
Mitostatic action of 4,6-dimethyl-2-amino-3,4,5-trimethoxyphenyl-pyrimidine on mammalian cells.
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Aniline Compounds↗
Irreversible inactivation by 2-amino-4,6-dichloropyrimidine of certain structural proteins of poliovirus.
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Centrifugation, Density Gradient↗
Low virulence and immunogenicity in mice and in rabbits of variants of Herpes simplex virus resistant to 5-iodo-2-deoxyuridine.
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Animals↗
In vitro and in vivo inhibitory action of 2-amino-4,6-dichloropyrimidine on polio and herpes virus.
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Animals↗
Characteristics of the inhibitory action of D-penicillamine on the growth of poliovirus.
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Guanidines↗
5-Iodo-2-deoxyuridine resistance of vaccinia viruses in cells endowed with thymidine kinase activity.
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Bromodeoxyuridine↗
Co-existence of a guanidine-dependence and of a thiopyrimidine dependence in the same strain of poliovirus.
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Carcinoma↗
On the mechanism of the inhibitory action of 2-amino-4,6-dichloropyrimidine on poliovirus growth.
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Amines↗
Irreversible impairment produced by guanidine on the functions of poliovirus proteins.
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Alanine↗
Behaviour of a guanidine-dependent strain of poliovirus 1 in sucrose density and pH gradients.
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Centrifugation, Density Gradient↗
Thiopyrimidines: specific inhibitors of poliovirus induced early cell damages.
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Antiviral Agents↗
Specific inhibition of poliovirus induced blockade of cell protein synthesis by a thiopyrimidine derivative.
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Antiviral Agents↗