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Biomedical subjects

B M Achauer

Publications and source records attributed to B M Achauer.

116 records · Page 7Linked to original sources
PubMedDate not supplied

Salvage of ear cartilage in patients with acute full-thickness burns.

Three cases in which the temporoparietal fascial flap was used to salvage denuded ear cartilage during the acute period after burn injury are reported. Patients' burns ranged from 30% to 75% total body surface area. The full-thickness burn was acutely excised, exposing the auricular cartilage. The temporoparietal facial flap was elevated and wrapped around the cartilage. The flap was then covered with a split-thickness skin graft. All flaps and skin grafts survived. Additional reconstructive procedures have been performed on two of the patients and are planned for the third.

Acute Disease↗
PubMedDate not supplied

The hemostatic effect of fibrin glue on graft donor sites.

One of the main uses of topical fibrin glue is hemostasis. Fibrin glue from pooled human plasma has been used in Europe for many years. It was used for fixation of skin grafts as early as 1944. Because of the risk of hepatitis and now of acquired immunodeficiency syndrome, this compound has not been approved by the U.S. Food and Drug Administration for use in the United States. It is now possible to make fibrin glue from a single unit of blood. Many blood banks have this capability, and burn centers in the United States are beginning to report its use in skin grafting procedures performed on patients with burns. In an effort to document a hemostatic effect, a prospective double-blind study was designed. Donor sites of patients with burns undergoing skin grafting were studied to provide a uniform wound; anatomic location varied, particularly with respect to gravity. Half of each donor site was sprayed with thrombin and fibrin glue, and the other half was sprayed with thrombin and placebo. A large absorbent pad was placed over the gauze dressing, and all dressings were collected and weighed by the investigators at 6 and 18 hours after the operation. Ten patients have been studied to date. In five patients slightly more bleeding occurred in the site treated with fibrin. One patient had no difference, and four had slightly less bleeding on the donor site treated with fibrin. No significant difference could be found in this initial study group.(ABSTRACT TRUNCATED AT 250 WORDS)

Burns↗
PubMedDate not supplied

Hot-press hand burn treatment.

Hand injuries are common in the workplace. Modern industrial machines cause complex occupational hand injuries. Hot-press contact hand burns generally are encountered by workers in the dry-cleaning industry. Seventeen patients with hot-press hand burns were treated at the University of California-Irvine Medical Center Burn Center. Eight patients (47%) required skin grafting, seven (41%) were treated with hydrotherapy only, and two (12%) needed flaps. These results were not what we expected.

Adolescent↗
PubMedDate not supplied

A multicenter clinical trial to evaluate the topical hemostatic efficacy of fibrin sealant in burn patients.

Current surgical management of deep partial-thickness and full-thickness burn wounds involves early excision and grafting. Blood loss during these procedures can be profound, thus prompting the use of topical hemostatic agents to control and minimize hemorrhage during grafting. The primary endpoint of this multicenter trial was to evaluate the efficacy of fibrin sealant as a topical hemostatic agent during skin grafting. The secondary endpoint was to obtain data to support the existing safety profile of a human fibrin sealant (FS) in participating patients as indicated by the type, severity, and frequency of any adverse events within the 24-hour postoperative period. A multicenter prospective, open label, Phase III multicenter, randomized, comparative clinical trial evaluated the use of fibrin sealant in burn patients undergoing skin graft procedures. Each patient served as his or her own control in this randomized, unblinded study of the effect on time to hemostasis in donor sites treated with the investigational FS product. At operation, 1 contiguous donor skin harvest site was bisected into 2 equal halves, 1 of which was then randomly selected and treated with fibrin sealant. At the end of the fibrin sealant application, the time to hemostasis in each of the donor site halves was identified by the operating surgeon and recorded by the research coordinator. The use of any other topical hemostatic agents was prohibited. A significant difference (P < .001) was demonstrated in the mean time to hemostasis between the fibrin sealant treated donor sites when compared painwise to the control sites. The significant difference was consistent across the 6 participating study centers. There were no adverse events associated with the use of fibrin sealant. The investigational FS product was shown to be efficacious, because it significantly decreases the time to hemostasis at the donor skin harvest site in patients undergoing skin grafting and was noted not to cause any adverse reactions.

Administration, Topical↗
PubMedDate not supplied

Fire pit burns.

Explore the source record for details and available documents.

Adult↗
PubMedDate not supplied

Cyclosporine-induced long-term allograft survival and its potential in posttrauma tissue replacement.

This report is a partial review of our work to date concerning the use of cyclosporine and integumentary/musculoskeletal allografts for posttrauma tissue replacement. Our ultimate goals for such allografts are their lifesaving capabilities in addition to their utilization in functional and aesthetic surgical reconstructions. The potential for such a treatment regimen to produce anatomical replacement of lost parts is a primary motivating reason to pursue such studies. Permanent host-accepted integumentary/musculoskeletal allografts would appear to offer much greater promise in comparison with recent synthetic and cultured tissue replacements. Summarized topics covered in this review include short- and long-term use of cyclosporine in a 30% body surface area rat burn model; bacterial studies in this model; primary wound excision and use of cyclosporine in a massive 80% body surface area rat burn model; pathological skin alterations in cyclosporine-treated rats; the synergistic immunosuppressive effects of prior blood transfusions and cyclosporine; long-term residual cyclosporine levels assayed in various long-term surviving allograft-recipients; and the use of cyclosporine and cadaver skin allografts to treat massive full-thickness burns in patients.

Animals↗