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Biomedical subjects

B M Bedi

Publications and source records attributed to B M Bedi.

At least 19 recordsLinked to original sources
PubMed1980

Macrophage culture from untreated leprosy cases.

Macrophage cultures from the peripheral blood were performed in 25 untreated bacteraemic leprosy patients. The monocytes on conversion to macrophages in culture continued to harbour solidly stained M. Leprae till the termination of culture. It is suggested that the majority of these bacilli are viable and capable of multiplication intracellularly in macrophages if cultures could be maintained for sufficiently long periods. It was observed that bacteraemia in Leprosy can be detected by the culture technic. It has been found to be more sensitive than the leukocyte adherence method.

Cells, Cultured↗
PubMed1979

Behaviour of macrophages to Mycobacterium leprae. A tissue culture study.

Macrophage culture was performed on 45 healthy adults who were initially categorised on the basis of their Lepromin reactivity using Dharmendra antigen. There were 25 individuals in the Lepromin positive group and 20 in the Lepromin negative group. The cultures were challenged with M. leprae and the macrophages studied at varying time intervals of culture. No difference was evident in the behaviour of cultured macrophages to M. leprae in both the groups. The Lepra bacilli were phagocytosed by the macrophages and retained essentially intact till the termination of culture. The Lepromin reactivity of a healthy individual was not reflected on the macrophage function in vitro. The observations suggested against the possibility of an intrinsic genetically determined macrophage defect in dealing with M. leprae.

Adult↗
PubMed1978

Persistence and distribution of Mycobacterium leprae in Aedes aegypti and Culex fatigans experimentally fed on leprosy patients.

Laboratory reared Aedes aegypti and Culex fatigans were experimentally fed on untreated lepromatous leprosy patients and the proboscides, guts and faeces of the mosquitoes were examiend at 12 hour intervals to determine the persistence and distribution of Mycobacterium leprae. In A. aegypti, bacilli persisted in proboscis till 156 hours, in gut 96 hours, and in faeces 72 hours after feeding. In C. fatigans--proboscides 144 hours, gut 96 hours and faeces 72 hours after feeding. In A. aegypti solid bacilli were present in proboscis upto 96 hours; in gut 48 hours and in faeces 42 hours after feeding. Corresponding figures for C. fatigans were: 144 hours for proboscis, 48 hours for gut, solid bacilli being absent in faeces. The results are discussed from the point of view of arthropod transmission.

Aedes↗
PubMed1977

Transfer of leprosy bacilli from patients to mouse footpads by Aedes aegypti.

Aedes aegypti mosquitoes which were first allowed to feed on untreated lepromatous leprosy patients, and then to refeed on mouse footpads were found to transfer Mycobacterium leprae to the footpads as seen by the subsequent multiplication of the bacilli in the footpads. Results presently available are insufficient to come to any conclusion about the actual role of mosquitoes in the transmission of leprosy in the field.

Aedes↗
PubMed1976

Subcutaneous phycomycosis from Pondicherry, South India.

Four cases of subcutaneous phycomycosis diagnosed by isolating Basidiobolus meristosorus from affected tissue, are reported along with the growth characters and morphological features of this fungus. This is the first report from Pondicherry, South India where it was it was possible to isolate the causative fungus from each case.

Adult↗
PubMed1976

Delayed hypersensitivity tests with Mycobacterium leprae purified protein derivative.

Skin tests were conducted on 3 lepromatous, 3 dimorphous and 6 tuberculoid leprosy patients and 3 others not suffering from leprosy with lepromin, purified protein derivative from M. leprae of armadillo origin and tuberculin. Results show that a delayed hypersensitivity reaction could be produced with PPD in 72 hours on all Mitsuda positive cases, with one anomalous exception, without cross reaction to tuberculin. The results were promising from the point of view of substituting lepromin with PPD in usual tests.

Animals↗
PubMed1975

Tinea capitis in Pondicherry (South India).

Amongst 125 cases of tinea capitis, representing 12-5% of dermatomycosis, about 9% showed kerion-like lesions and 13% had tinea corporis and/or tinea unguium. Eighty four percent cases were mycologically positive, yielding Trichophyton violaceum (84%) or T. tonsurans (16%).

Adolescent↗
PubMed1975

Donovanosis (granuloma inguinale) of the oral cavity.

A female patient suffering from donovanosis of the oral cavity without associated lesions elsewhere is reported. The importance of remembering donovanosis in the differential diagnosis of chronic granulomatous ulceration of the mouth is emphasized.

Adult↗
PubMed1975

Tinea nigra palmaris from South India.

A middle aged woman was diagnosed as a case of tinea nigra palmaris in a Pondicherry hospital. Ascraping from a dark patch on her palm yielded Cladosporium werneckii. This is the first report of mycologically confirmed tinea nigra palmaris from India.

Female↗