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Biomedical subjects

B M Box

Publications and source records attributed to B M Box.

9 recordsLinked to original sources
PubMed1983

Nutrition and hypertension.

There has been a good deal of interest in the relation of nutrition to cardiovascular diseases and this is likely to continue. We consider recent research developments concerned with the well known examples of the association of high salt intake with hypertension and of saturated fats with atherosclerosis. Some of the difficulties encountered in the investigation of dietary factors in hypertension are similar to those encountered in the investigation of dietary factors in atherosclerosis and coronary heart disease. Much additional research, which takes into account the multifactorial nature of cardiovascular disease, is needed to determine the effects of diet on the development and treatment of these diseases.

Animals↗
PubMed1982

Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats.

The effect of dietary variations in linoleic acid (LA) on the development of hypertension was studied in young male spontaneously hypertensive rats (SHR). All groups developed elevated systolic blood pressures, but after 7 weeks on the experimental diets the blood pressures of the rats fed the diet with a low LA content (0.17% as supplied by 8% coconut oil) were significantly lower than the group fed a high level of LA (9.5% as supplied by 17% corn oil) in the diet. Rats fed the high LA diet had increased urine output and developed a mild but persistent polydipsia. After 4 months on the experimental diets, potassium excretion was decreased in proportion to the amount of LA in the diet but sodium excretion was not altered. Serum potassium was significantly elevated in the group fed high LA after 5 months. The effects of LA on hypertension of SHR appear to be opposite to those observed during salt-induced hypertension. Since LA is the dietary precursor of the prostaglandins, the effects observed may be due to the availability of precursor for renal prostaglandin synthesis which has been reported to be altered in SHR.

Animals↗