Biomedical subjects
Publications and source records attributed to B M Dajani.
In decorticate-decerebellate cats with cervical spinal cuts which isolated the dorsal columns (DCs), conditioning volleys travelling in the DCs inhibited activities of trigeminal caudalis neurons. This inhibition was most likely mediated through a brainstem loop and was particularly effective on nociceptive-driven neurons.
In decerebrate-decerebellate cats, stimulation of trigeminal afferents inhibited neurons in dorsal column (DC) nuclei driven by activation of DC input and produced primary afferent depolarization in DC primary afferent terminals. This inhibition was most likely mediated by a trigeminal-brainstem-DC nuclear loop.
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Eleven patients with intrinsic asthma and aspirin sensitivity were challenged with intravenous hydrocortisone sodium succinate (Solu-Cortef; the Upjohn Co., Kalamazoo, Mich.). Three patients showed definite evidence of bronchospasm, which was easily reversed by subcutaneous administration of epinephrine. Evidence is presented which suggests that this reaction was not caused by other constituents of the preparation but rather was caused by Solu-Cortef alone. No atopy was demonstrated in the group as a whole, and the reaction observed was probably nonallergic in nature. We suggest the replacement of intravenous hydrocortisone sodium succinate with dexamethasone in the treatment of such a population.
A sample of 144 male, and 117 female healthy adults was selected to determine the normal ventilatory functions for Jordanians. Forced vital capacity, FEV1, and FMF 25-75% were determined using a dry bellows spirometer. Linear regression curves and nomograms were constructed for predicted values. Jordanian values for FVC and FEV1 were similar to those of Caucasians living in the western hemisphere.
The effect of an oral dose of 20 mg of rifampin per kg per day on the immune response to killed Mycobacterium bovis var. BCG, 1-chloro-2,4-dinitrobenzene (DNCB), and sheep red blood cells (SRBC) was studied in adult female guinea pigs. Fully established cutaneous reactions to BCG or DNCB were markedly reduced during rifampin treatment but reverted to pretreatment levels after the drug was discontinued. When treatment was begun 7 days after immunization, positive reactions did not occur during drug administration but developed after cessation. When treatment was initiated 7 days before immunization, the response to these agents was completely suppressed during but also after rifampin was discontinued, suggesting that recognition and processing of the immunogens had been impaired. Rifampin had no effect on the secondary response to SRBC. When treatment was initiated either 7 days before or 2, 3, or 4 days after SRBC immunization, the primary response was abolished, but the reaction to a booster after drug withdrawal varied: some animals developed a normal secondary hemagglutinin response, but the majority reacted as if they had not been previously immunized. These studies indicate that rifampin is an active immunosuppressive agent in the guinea pig.
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