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Biomedical subjects

B M Harnoss

Publications and source records attributed to B M Harnoss.

14 recordsLinked to original sources
PubMed1992

[Cystadenoma and cystadenocarcinoma of the pancreas. Symptoms, diagnosis and surgical consequences].

Seven cases of cystadenomas and cystadenocarcinomas were presented and the treatment of the cystic tumours of the pancreas was discussed in a surgical point of view. Distinction between true cysts like cystadenomas and pseudocysts following pancreatitis is of paramount importance. The clinical findings are mostly uncharacteristic and determinated by the late symptoms. The diagnosis of cystic tumours can usually be made by radiological imaging technique. Intraoperative examination of the frozen-sections is of paramount importance for the choice of the surgical procedure and hence the prognosis of the patient. Radical surgery is indicated in case of cystadenoma or cystadenocarcinoma. Every mucinous cystic neoplasm should be completely examined in carefully lamillated sections in order to identify its malignancy.

Adult↗
PubMed1989

[Experiences with endoscopic recanalization using the Nd-YAG laser in tumor ileus and inoperable rectal cancer].

In the time period from January 1, 1987 until October 1, 1988, a total of 17 patients with an advanced colorectal tumor underwent transendoscopic laser treatment with the Nd-YAG laser. Eight patients had a tumor-dependent passage disorder with a large intestinal ileus as initial finding. Recanalisation and decompression of the intestine were successfully performed in 7 cases, so that placement of an anus praeternaturalis could be avoided. In another 8 patients the advanced rectal tumors were subjected to laser irradiation, 6 times because of subtotal stenosis and 3 times because of tumor bleeding. A locoregional radiatio (afterloading) was performed in each case.

Aged↗
PubMed1989

[Anastomotic aneurysm].

The incidence of postoperative suture aneurysms shows a generally regressive tendency. Within the last 10 years, we diagnosed anastomotic aneurysms in 66 of a total of 2,494 patients undergoing vascular reconstruction with implantation of alloplastic material at our clinic. Aneurysms were primarily located in the inguinal region (88%); intraabdominal suture aneurysms were diagnosed in 9% of all cases. Infection was the cause of postoperative anastomotic insufficiency in eleven cases (17%) with staphylococci and E. coli being the dominant pathogens.

Aneurysm↗
PubMed1988

[Endotoxinemia and bacteremia in manual oral decompression of ileus].

In the framework of the present clinical prospective study using a randomly selected patient collective, the question was pursued whether manual oral decompression (MOD), done in connection with surgical intervention in severely ill patients with ileus of the large and small intestine, leads to detectable bacteremia or higher concentrations of endotoxin in serum. From October, 1985 to March, 1987, bacteriological tests were conducted and the endotoxin concentrations in serum were measured in a total of 31 patients. 71% of the patients were female and 29% were male, aged 18-89. The endotoxin measurement was conducted with the aid of the limulus-amoebocyte-lysate (LAL) test, modified according to Piotrowicz. Additionally, bacteriological tests were done of the operation sites and the decompressed gastro-intestinal secretions. Simultaneously, cultures from the central blood stream were prepared. The tests showed that bacteremia and endotoxinemia occur in connection with manual oral decompression (MOD). Neither of the two, however, has any clinically relevant influence on the further post-operative course. Thus, manual oral decompression continues to represent an indispensable maneuver in the surgical management of an ileus.

Adolescent↗
PubMed1987

Perioperative antibiotic prophylaxis in bile-duct interventions: results of two prospective randomized studies.

The success of perioperative prophylaxis in gallbladder surgery was examined in two prospective randomized studies with a total of 326 patients. Postoperative wound-healing impairments did not occur in any of the patients receiving a single preoperative application of an antibiotic with a high biliary elimination rate (ceftriaxone or apalcillin). 11% of a control group without prophylactic antibiotic application evidenced infectious wound-healing disturbances.

Adolescent↗
PubMed1986

[Systemic antibiotic prophylaxis with metronidazole in elective colonic and rectal surgery. Results of a clinical controlled study and a critical literature review].

The pathogen spectrum of wound infections in colon surgery is composed almost exclusively of facultatively aerobic and obligatorily anaerobic intestinal flora. A study was performed in which a one-shot prophylaxis was carried out by applying metronidazole, 500 mg i.v., or latamoxef (lamoxactam) 2 g i.v., on induction of anesthesia. The metronidazole group evidenced a 26.3% incidence of infections due exclusively to aerobic pathogens. In the latamoxef (lamoxactam) group, it was possible to achieve a reduction of the postoperative rate of wound infections to 11.1%. The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens.

Colon↗
PubMed1985

Antibiotic infection prophylaxis in gallbladder surgery--a prospective randomized study.

In the course of 1 year, 180 patients undergoing elective surgery for confirmed cholelithiasis were included in a prospective randomized study in which they either received 2 g of preoperatively applied ceftriaxon intravenously at the beginning of anesthesia or, as an alternative, no antibiotic at all. Infectious wound-healing disturbances occurred postoperatively in 11% in the control group and in no case in the prophylaxis group. The difference is statistically significant.

Adolescent↗
PubMed1985

Biliary elimination of apalcillin in cholecystectomized patients.

Pharmacokinetic examinations were performed in 5 patients with bile-duct drainage following cholecystectomy and choledochus revision with 2 g of apalcillin over 20 min intravenously. In comparison to healthy volunteers they had significantly longer half-life values and long persisting serum concentrations over a period of 24 h. The biliary elimination rate of apalcillin correlated with the hepatic function of the patients and was with 4.3% on the average distinctly lower than that of healthy volunteers, whereby the bile, however, could probably not be collected quantitatively in cases of open papilla. Compensatory excretion of apalcillin took place via the kidneys and, considering the metabolites A1 and A2, it amounted to a total of 73%.

Adult↗
PubMed1982

[Recurrent ulcer after stomach resection--its operative therapy with reference to etiology and pathogenesis].

Over a period of 12 years, 100 patients with a confirmed ulcer recurrence after prior gastric resection underwent a standardized surgical procedure. The mortality rate of the electively operated patients amounted to 1 per cent. The follow-up examination yielded satisfactory surgical results in over 80 per cent of the patients treated in this way. We consider the exclusively abdominal procedure suitable in cases of recurrent ulcer in order to ensure adequate diagnosis and therapy.

Adolescent↗
PubMedDate not supplied

Self-expandable macroporous nitinol stents for transfemoral exclusion of aortic aneurysms in dogs: preliminary results.

This experimental study evaluated the feasibility of excluding artificially created aortic aneurysms in dogs with transfemorally inserted nitinol stents, serving as intraluminal bypass. Infrarenal aortic aneurysms were created in eleven dogs (28-35 kg) by end-to-end anastomosis of sacciform conduits. Single and double wire-knitted, macroporous, superelastic, self-expanding nitinol stents without any additional wrapping or in-between fabrics served as endovascular grafts. The pore size of the double-knitted stents was less than 0.7 mm2. Angiography following stent placement showed immediate exclusion of the aneurysms for the double-knitted stents. For the single-knitted stents (2 cases), partial exclusion was achieved only after considerable delay. CT studies in the dogs with the double-knitted stents revealed patency of the grafts after 3 to 5 weeks with the aneurysms totally thrombosed. So far gross pathology of 1 dog at 24 h and 1 at 12 months revealed patency of the stents. At 12 months histopathology showed a neointima covering the inner stent surface with the aneurysm filled by an organized thrombus. It is concluded, that an "open" stent with a tight meshwork appears to be a suitable device to instantly exclude artificial aneurysms of the canine aorta.

Alloys↗