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Biomedical subjects

B M Hegde

Publications and source records attributed to B M Hegde.

At least 19 recordsLinked to original sources
PubMed2000

Effect of N-2-mercaptopropionylglycine in limiting myocardial reperfusion injury following 90 minutes of ischemia in dogs.

Present study was designed to examine the effectiveness of N-2-mercaptopropionyl glycine (MPG) on oxygen free radical (OFR) mediated reperfusion injury. Twenty dogs underwent 90 min of left anterior descending (LAD) coronary artery occlusion followed by 4 h of reperfusion. In control animals (n = 12), 115 ml of saline was infused through left atrium at the onset of reperfusion whereas treated animals (n = 8) received loading dose of MPG (40 mg/kg) infused through left atrium for 1 h followed by maintenance dose (25 mg/kg) for remaining 3 hours. Percentage area of necrosis vis-a-vis area at risk and percentage necrosis in left ventricular mass in MPG treated animals was significantly lower in comparison to control animals. Reperfusion in control group increased the lipid peroxidation and lowered glutathione (GSH) and superoxide dismutase (SOD) activity. MPG treatment significantly lowered the lipid peroxidation whereas GSH and SOD levels in necrotic zone were higher than in control. The above results suggest that MPG can offer a significant cardioprotection against oxidative stress in canine model.

Animals↗
PubMed2000

Face of God.

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History, 17th Century↗
PubMed2000

Medical philosophy.

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Developing Countries↗
PubMed1999

Principles of drug therapy in hypertension.

The most difficult diagnosis in medicine is the diagnosis of hypertension. Since this label encompasses many maladies both known (secondary hypertension), and the unknown, the office recording of blood pressure alone will not suffice to warrant treatment with drugs right away. There are more than 6 major guidelines in the world about the rules of the game of drug therapy in hypertension. The present preoccupation with newer drugs as first line antihypertensive drugs would ruin any economy, if the exchequer is to foot the bill. The stress in drug treatment has been the step-care mode of drug therapy where one starts with one drug in small doses, building the dose gradually, adding the next drug to get cumulative power to lower the pressure. Since the early seventies, the need to step-down therapy is being stressed wherein the doctor starts cutting down the drugs and the dosage, once he achieves the desired blood pressure levels. Diuretics and beta-blockers should be the first choice when drugs are indicated, unless there are positive indications for other drugs, or the first line drugs are contra-indicated. Routine treatment with drugs is recommended by the American JNC for people with sustained blood pressure above 140/90 mm Hg, but the British recommendations put the cut off at the pressure level of 160/100 mm Hg. Indian patients respond to very small doses in the beginning. The Hypertension Optimal Treatment (HOT) study failed to demonstrate a significant difference between the 3 randomised target blood pressure groups for the majority of cardiovascular events, although it did prove the theoretical hypothesis, that more vigorous treatment could certainly bring down the measured blood pressure to greater extent in 90% of patients I Greater importance will be given in the future for the non-pharmacological approaches, as well as to baseline blood pressure values, at which drug treatment should be started.

Adrenergic beta-Antagonists↗
PubMed1999

Grudgitis.

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Hostility↗
PubMed1998

Serum estradiol and testosterone levels following acute myocardial infarction in men.

The present study examined serum testosterone and estradiol levels on the day of admission, 5th and on 10th day following acute myocardial infarction in men. Controls were matched for age and body mass index. Testosterone levels were low on the day of admission and remained statistically unchanged on 5th and 10th day as compared to controls. On the contrary, estradiol levels were significantly higher on the day of admission. A significant decrease in estradiol concentration in comparison to the levels on the day of admission was observed on 10th day post myocardial infarction. However, the estradiol levels on 10th day were significantly higher than control subjects. The results of the study suggest that in acute myocardial infarction, hyperestrogenemia is associated with hypotestosteronemia.

Aged↗
PubMed1998

Effect of N-acetylcysteine on myocardial infarct size following ischemia and reperfusion in dogs.

The present study was designed to examine the role of N-acetylcysteine (NAC) on free radical mediated reperfusion injury in canine model. Fourteen dogs underwent 90 min of left anterior descending coronary artery (LAD) occlusion followed by 4 h of reperfusion. Treated animals received loading dose of NAC (250 mg/kg) at the time of reperfusion upto 1 h followed by maintenance dose (70 mg/kg) for remaining 3 h through left atrial line. Infarct size, myocardial tissue lipid peroxidation, superoxide dismutase (SOD) and glutathione (GSH) levels were measured at the end of reperfusion in treated (n = 7) and untreated animals (n = 7). Left ventricular end diastolic pressure was significantly lower in treated animals compared to untreated group. SOD and GSH levels in myocardial tissue at risk and in infarcted zone were similar in both groups. However, in NAC treated animals the lipid peroxidation was significantly lower in comparison to untreated control animals. Infarct size in the area at risk, percent left ventricular necrosis and myocardial tissue preservation were not significantly different in treated and untreated animals. These results suggests that N-acetylcysteine infusion at the time of reperfusion following 90 min of ischemia and 4 h of reperfusion fails to offer significant cardioprotection against free radical damage but it can improve ventricular performance by decreasing pre load.

Acetylcysteine↗