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Biomedical subjects

B M Hill

Publications and source records attributed to B M Hill.

10 recordsLinked to original sources
PubMed1992

New-wave nursing: back to the basics?

The experience of nurse leaders in a multi-institutional system from the initial stages of deliberation to the concluding consensus to commit to an extensive restructuring project is described in this article. Significant factors in evaluating the potential for success or failure of such a project are described, and the impact of restructuring on nursing practice is considered. Change is inevitable; restructuring is an appropriate way to accomplish change, and leadership may direct the change to create something new while also preserving nursing's strengths.

Humans↗
PubMed1992

Comparison of plastic vs. glass evacuated serum-separator (SST) blood-drawing tubes for common clinical chemistry determinations.

We evaluated a plastic evacuated blood-drawing tube containing an integral serum-separating barrier gel, by direct comparison with a glass counterpart. The plastic tube demonstrated no differences when compared for common clinical chemistry analytes with multiple types of instruments and systems. A total of 260 such different combinations were studied with emphasis on tests sensitive to drawing and handling indexes such as lactate dehydrogenase and potassium. A total of six separate blood drawings were tested with no significant differences noted in these tests. The total study included subjective evaluations of the plastic tube's use as a blood-drawing device and objective studies based on quantitative test results from normal and hospitalized patients and use of the primary sampling tubes (both plastic and glass) for 48-h storage.

Blood Specimen Collection↗
PubMed1985

Antibiotic residue release at the beginning of lactation following dry cow therapy.

In response to farmer complaints about unfair penalties, for the presence of inhibitory substances in early lactation following the use of dry-cow antibiotic therapy, a two-part study was carried out to try and establish why these unexplained grades occur. A survey of instructions supplied with each of 13 registered dry-cow products suggested that the directions for drug use were in some cases inappropriate for long-acting antibiotics. A residue release study was conducted at the beginning of lactation following antibiotic therapy at various times during the dry period. The results showed, for the-three dry-cow preparations studied, that treatment during the dry period, especially within six weeks of calving, could lead to detectable residues in milk from treated quarters.

Journal Article↗
PubMed1984

Antibiotic residues in goats milk following intramammary treatment.

Two lactational intramammary antibiotic preparations (cloxacillin and oxytetracycline) were each used to treat eight goats by intramammary infusion in one half. The rate of release of the antibiotics was monitored by a diffusion assay based on the sensitive organism Bacillus stearothermophilus var. calidolactis. Cloxacillin was still detectable 156 hours after the final treatment while oxytetracycline was undetectable 108 hours following treatment. A small but significant amount of antibiotic was translocated between treated and untreated halves of the udder in both cases.

Journal Article↗
PubMed1979

Liquid-chromatographic analysis for methylphenidate (Ritalin) in serum.

We describe a "high performance" liquid chromatographic method for quantitating methylphenidate in serum. The internal standard, 4,5-diphenylimidazole, and serum or plasma sample are extracted in chloroform, evaporated, and redissolved in 20 mmol/L potassium phosphate (pH 3.5)/high-purity acetonitrile, 80/20 by vol. A centrifuged aliquot is chromatographed on mu-Bondapak C-18 with the phosphate/acetonitrile solvent as mobile phase, a flow rate of 1.6 mL/min, and a column temperature of 40 degrees C. Absorbances are read at 192 nm. This method reliably measures concentrations greater than 20 micrograms/L and has analytical recoveries of 74%.

Child↗
PubMed1979

A liquid-chromatographic analysis for ritalinic acid [alpha-phenyl-alpha-(2-piperidyl) acetic acid] in serum.

We describe a "high-performance" liquid-chromatographic assay for measuring ritalinic acid in 300 muL of serum. The procedure includes adsorption of ritalinic acid and internal standard (alpha,alpha-dimethyl-beta-emthylsuccinimide) from serum onto charcoal, from which both compounds are eluted with methanol. The methanol extract is evaporated, the residue dissolved in a 93/7 (by volume) mixture of potassium phosphate buffer (20 mmol/L, pH 3.8) and acetonitrile, and an aliquot of this solution is chromatographed. We used a mu-Bondapak C-18 column with the above-mentioned buffer system as mobile phase, a flow rate of 2.0 mL/min, and a column temperature of 40 degrees C. Ritalinic acid and internal standard are detected by their absorbance at 192 nm and quantitated by measuring peak heights. The procedure allows for the reliable analysis for ritalinic acid in serum at concentrations greater than 50 microgram/L. Analytical recoveries were greater than 73% and the method affords good day-to-day precision (CV, less than 12%).

Chromatography, High Pressure Liquid↗
PubMed1973

IgE antibody measurements in ragweed hay fever. Relationship to clinical severity and the results of immunotherapy.

Specific IgE anti-ragweed antibodies (IgEAR) were measured over two years in two groups of highly sensitive patients treated (immunized) with either ragweed extract or placebo and in a third group of placebo-treated, relatively insensitive patients. The IgEAR on the patients' basophils were assessed by ragweed antigen E (AgE)-induced histamine release; blocking (IgG) antibodies were measured by their ability to inhibit AgE induced histamine release. These data were evaluated against the clinical severity of ragweed hay fever in each patient. WE FOUND THAT: (a) In placebo treated patients IgEAR usually declined gradually prior to the ragweed season and were boosted by environmental exposure to ragweed pollen. (b) In immunized patients the IgEAR rose at the beginning of treatment, but fell as immunotherapy proceeded; by the end of the second year the levels had decreased in 18/19 patients. (c) The increase in blocking antibody during immunotherapy correlated significantly (P < 0.05) with the decrease in serum IgEAR. (d) Judged by their sensitivity to AgE induced histamine release, IgEAR on basophils correlated significantly with IgEAR in the serum of untreated patients (P < 0.01). (e) The highly sensitive placebo treated patients' symptom scores were significantly correlated with their IgEAR in serum (P < 0.01) and with the sensitivity of their basophils to AgE-induced histamine release (P < 0.01). Neither correlation was observed in the relatively insensitive patients. (f) In the treated group the IgEAR measurements predicted neither the degree of their illness nor their clinical improvement We conclude tha IgE antibody measurements may be useful in the assessment of the severity of reaginic allergy in highly sensitive patients. Its use in modestly sensitive patients requires patients requires further study, as does the inverse association between IgE and IgG antiragweed antibodies.

Adult↗