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Biomedical subjects

B M KAGAN

Publications and source records attributed to B M KAGAN.

At least 19 recordsLinked to original sources
PubMed1964

INDUCTION BY ANTIBIOTICS AND COMPARATIVE SENSITIVITY OF L-PHASE VARIANTS OF STAPHYLOCOCCUS AUREUS.

Molander, C. W. (Cedars of Lebanon-Mount Sinai Hospitals, Los Angeles, Calif.), B. M. Kagan, H. J. Weinberger, E. M. Heimlich, and R. J. Busser. Induction by antibiotics and comparative sensitivity of L-phase variants of Staphylococcus aureus. J. Bacteriol. 88:591-594. 1964.-The penicillins, cephalothin, vancomycin, and bacitracin were found to be less inhibitory to the L-phase variants than to their respective parent bacteria. Those antibiotics not considered to be primarily inhibitors of cell-wall synthesis were, in general, somewhat more inhibitory to the L form than to their parent bacteria. Only the penicillins and cephalothin readily induced L-phase variation. Novobiocin induced pleomorphic growth resembling the earliest stages of L-phase transformation. Failure of observable induction by bacitracin and vancomycin suggests that these two antibiotics affect cell-wall synthesis in a manner different from the penicillins, or that L-phase transformation may require more than "penicillin-like" interference with cell-wall synthesis.

Anti-Bacterial Agents↗
PubMed1964

SENSITIVITY OF COCCAL AND L FORMS OF STAPHYLOCOCCUS AUREUS TO FIVE ANTIBIOTICS.

Kagan, B. M. (Cedars of Lebanon Hospital, Los Angeles, Calif.), Susan Zolla, R. Busser, and Silvija Liepnieks. Sensitivity of coccal and L forms of Staphylococcus aureus to five antibiotics. J. Bacteriol. 88:630-632. 1964.-Antibiotics whose primary site of action is in the cell wall (penicillin and cephalothin) do not inhibit growth of L-phase organisms. In this study, kanamycin, neomycin, polymyxin B, lincomycin, and gentamycin were found to be more active against L-phase growth of Staphylococcus aureus in vitro than against the coccal forms. Therefore, their primary site of antimicrobial activity appears to be other than that involved in the synthesis or integrity of the cell wall.

Anti-Bacterial Agents↗