Biomedical subjects

B M Manzini

Publications and source records attributed to B M Manzini.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Contact sensitization in children.

Our study concerns contact sensitization in children, the frequency of which is still debated in the literature, even though specific reports are increasing. During a 7 year period (1988-1994) 670 patients, 6 months to 12 years of age, were patch tested with the European standard series, integrated with 24 haptens, at the same concentrations as for adults. We observed positive results in 42% of our patients. Thimerosal, nickel sulfate, Kathon CG, fragrance mix, neomycin, wool alcohols, and ammoniated mercury induced most of the positive responses. The highest sensitization rate was found in children from 0 to 3 years of age. Comments on main positive haptens are reported. Seventy-seven percent of our sensitized patients were atopics, suggesting that atopy represents a predisposing factor for contact hypersensitivity. Patch testing represents a useful diagnostic procedure for the definition of childhood eczematous dermatitis and for the identification of agents inducing contact sensitization which is frequently associated with atopic dermatitis.

Child↗

PubMedDate not supplied

[Contact sensitization to thimerosal in healthy subjects].

The aim of our study was to evaluate the prevalence of thimerosal allergy in subjects free of dermatitis. 256 recruits, selected by the Military Health Authorities as healthy subjects, without dermatitis or ocular defects, underwent allergological examination. The percentage of sensitization observed (6.25%) was compared to that found among 2150 patients, consecutively admitted to the Allergological Service of our Department, with suspected allergic dermatitis. Here we found 76 positivities (3.53%). Contact sensitization to ammoniated-mercury is lower among thimerosal-negative subjects (1.88%) than among both the healthy group of thimerosal-positive subjects (12.5%) and thimerosal-positive patients (11.84%). In the group of 76 positive patients it was not possible to relate the sensitization to thimerosal to either a particular clinical dermatological picture or to a specific exposure.

Adolescent↗

PubMedDate not supplied

[Verruciform xanthoma. Presentation of a case and review of the literature].

We describe a patient with a lesion on the nose, which clinically seemed a filiform wart; when the histological examination was performed we diagnosed a verruciform xanthoma. Looking at the literature we saw that the clinical diagnosis of this lesion had never been possible. Moreover, the histopathology always showed a peculiar pattern: a very dense infiltrate of foamy cells which completely removed the upper dermis and stopped at the basis of the rete ridges. Hyperlipemia was found in no cases, when specific tests were performed. Most cases reported were in the oral cavity. Age, sex and race do not seem to be relevant. The etiology of this lesion is unknown. Authors always discuss the pathogenesis, i.e. whether the first damage responsible for the formation of the foamy cells is in the epidermis or in the dermis. Other hypothesis have been suggested. Nevertheless, the majority of the Authors agree about the histiocytic origin of the xanthoma cells.

Diagnosis, Differential↗