Biomedical subjects

B M Martín

Publications and source records attributed to B M Martín.

2 recordsLinked to original sources

PubMed1982

Effects of sphingolipids on erythroblastic maturation in the mouse.

The changes effected by injection of an extract of phospholipids obtained from the plasma of normal human donors (PLE) or an emulsion of commercially available sphingolipids on erythropoiesis in the mouse were studied. The parameters followed were 59Fe uptake by the erythroid tissue and the number of circulating reticulocytes. It was found that in the 12--24-h period following administration of PLE or purified sphingomyelin a significant increase in 59Fe uptake by circulating RBC an by their hemic fraction takes place. This change was associated with a higher 59Fe utilization by the bone marrow and with an increase in the number of circulating reticulocytes.

Animals↗

PubMed1980

Erythropoietic changes effected by foreign serum in the mouse.

Injection of foreign serum into mice increases erythrocyte formation as evaluated by ferrokinetics studies. When erythropoiesis is depressed either by fasting or plethora, the wave of erythropoiesis that follows a transient increase of endogenous erythropoietin is clearly enhanced by pretreatment of the recipients with foreign serum. The response includes a restoration of the responsiveness of the spleen of fasted mice to endogenous erythropoietin stimulation. These changes seem related to an effect of foreign serum on the transition of primitive hematopoietic progenitors into erythroid-committed progenitors.

Animals↗