Systemic lupus erythematosus with panniculitis--(lupus profundus).
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Biomedical subjects
Publications and source records attributed to B M Pulimood.
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A patient with long-standing filarial chyluria developed severe lymphocytopenia, extensive mucosal candidiasis and disseminated cryptococcosis when given small doses of prednisolone and azathioprine, for the treatment of a co-existing chronic active hepatitis. This report suggests that patients with chyluria are particularly susceptible to the complications of immunosuppressive therapy. This susceptibility is probably due to the immunological abnormalities associated with chyluria.
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Four cases of essential athrombia have been diagnosed in the 14 year period from June, 1966 to June, 1980 at the Coagulation Laboratory of the Christian Medical College Hospital, Vellore. All cases fit Inceman's description of the original case and fulfill the diagnostic criteria of prolonged bleeding time, decreased platelet aggregation, normal platelet count, normal morphology and normal clot retraction. No cases have been reported from India in the past 15 years.
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Three hundred and two cases of Landry-Guillain-Barré-Strohl syndrome (LGBSS) are studied and relevant literature is reviewed. The existing diagnostic criteria appear not in keeping with the histopathological and immunological findings of this condition, hence some modifications have been suggested. The role of steroids in the treatment of this disorder is critically examined, and no benefit is found to be gained from their use.
Diabetes mellitus coexisting with primary hypothyroidism is believed to be rare. Seventy-nine such cases were seen between 1960 and 1973. Statistically this association appears to be more frequent than the separate frequencies of the two disease warrant. The patients were mostly females, and invariably obese. Diabetes preceded hypothyroidism in the majority of cases. This frequent association is presumed to be of autoimmune origin.
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A partial gastrectomy of Billroth I or II type was performed in a series of 146 patients with peptic ulcer. Gastric biopsy was carried out two years later and the histology of the specimens compared with that of the body mucosa at the time of operation. In 138 patients without body atrophic gastritis (AG) before operation this condition was found in 74 (54%) two years after (46% of DU patients and 73% of GU patients). Those with antral or pyloric canal ulcers were particularly liable to develop AG (81%). Apart from site of ulcer various other factors possibly associated with the development of AG were examined: no positive correlations were found with the possible exception of anaemia. Gastric parietal cell antibodies were not found in any patient with AG tested. The cause of gastritis after partial gastrectomy and its possible relationship with gastric carcinoma are discussed.
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