[Life and work of Fedor Aristarkhovich Udintsev (on the centenary of his birth)].
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Biomedical subjects
Publications and source records attributed to B M Shchepotin.
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Experimental thyrotoxicosis was induced in rats and rabbits. The content of catecholamines was significantly decreasing in the myocardium of rabbits in the presence of severe thyroidine-induced toxicosis. The noradrenaline concentration was especially low in the ventricles. The histochemical examination of the myocardium of rats revealed a reduction of catecholamines fluorescence, which indicates a decrease in their amount in the adrenergic structures.
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Disseminated intravascular coagulation syndrome (DIC-syndrome) is experimentally reproduced by introduction of 30% aqueous solution "Desoxon-3" (2800-300 mg/kg) into the organism of laboratory animals (rabbits). The preparation was perorally introduced once on an empty stomach for 1 min. Biochemical and pathomorphological studies testify to the development of the typical DIC-syndrome in rabbits. It is concluded that the model suggested makes it possible to thoroughly study genesis, course, consequences of the development and preventive measures of disseminated intravascular blood coagulation, a complex pathological process.
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