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Biomedical subjects

B M Webber

Publications and source records attributed to B M Webber.

13 recordsLinked to original sources
PubMed1978

A combined treatment approach to management of hepatic metastasis.

Forty-eight patients with liver metastases were treated at Rhode ISland Hospital in a nonrandomized sequential manner between January 1972 and June 1977. Eight received 5 FUDR hepatic artery infusion, 14 hepatic irradiation, and 25 were planned for combined intra-arterial chemotherapy plus total hepatic irradiation. Those patients who successfully completed induction treatments had a median survival in the radiation only group of 140 days, in the intra-arterial chemotherapy group 270 days, and in the combined group 376 days. Hepatic radiation when combined with chemotherapy was well tolerated. Primary tumor site, disease duration, and degree of abnormality of liver function had no relationship to the response to treatment. The pretreatment performance level of the patient as determined by the Karnofsky Performance Index gave the best indication for potential response to combined therapy. Based on the results of this treatment and the reports of other series, it appears that the combination of intra-arterial 5 FUDR plus hepatic irradiation may offer prolonged and worthwhile palliation to appropriately chosen patients.

Bone Marrow↗
PubMed1978

A computer-assisted three-dimensional treatment planning system.

The three-dimensional treatment planning system developed at the Rhode Island Hospital visualizes the spatial interrelationships of the radiation beam, the tumor, and the adjacent organs within the patient. It is possible to rotate and vary the scale of the display to better comprehend the extent of these structures. By viewing the display as if from along the radiation beam, one can design shaped treatment fields which best suit the three-dimensional nature of the disease. With this system, it is possible to reduce the volume of normal tissue which would typically be irradiated if two-dimensional treatment planning techniques and assumptions were employed.

Computers↗
PubMed1976

Frozen section- frozen attitudes.

Patients with breast cancer who have clinically negative axillae, tumors 2 cm in diameter or less, and tumors with a moderate or low degree of anaplasticity are candidates for treatment by local excision and irradiation. A definitive histologic diagnosis should be made in all cases of breast cancer before a final treatment decision is made. This can be accomplished by needle or excisional biopsy. After a histologic diagnosis is established, the decision regarding treatment can be arrived at with the patient enering into the process. Those patients requiring mastectomy will be better able to cope with this, knowing why the operation was considered best for them. The elimination of frozen section diagnosis will free the patient from one of the great fears of the current treatment of breast cancer- subjecting herself to biopsy without knowing what the outcome will be. It will free the surgeon from the rigid sequence of frozen section followed by mastectomy and allow him to begin to rationally assign patients with proper criteria to conservative treatment, reserving mastectomy for those who do not meet these criteria.

Adult↗
PubMed1975

A table for the rapid determination of RET and TDF values.

A table has been devised to allow rapid determination of the RET and TDF values for five-day a week therapy schemes which might be included in realistic treatment planning. 2. The table allows easy comparison of the RET and TDF values for different fractionation schemes or, conversely, the devising of equivalent fractionations for similar RET and TDF values. 3. Utilizing the decay tables of Orton and Ellis, it is possible to utilize the table for determining rapidly the total TDF for interrupted or split course treatment regimens. 4. In those departments which treat four days, rather than five days, per week, a table devised on the four-day treatment schedule could easily be devised.

Radiotherapy Dosage↗