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Biomedical subjects

B Márkus

Publications and source records attributed to B Márkus.

12 recordsLinked to original sources
PubMed2004

[The place of Shouldice operation in inguinal hernia repair].

The Shouldice operation has been increasingly applied in our department since 1996. Between 1998-2000 its proportion has achieved 58% (Lichtenstein: 30%, laparoscopy: 2%, TEPP: 3%, other: 7%). A total of 343 patients have been operated on according to Shouldice. These patients were followed for 3-5 years in the mean. So far we observed 3 recurrences corresponding to a recurrence rate of 0.9%. The recurrence rate decreased compared to a historical control group from 10 to 0.9% using the Shouldice technique instead of Bassini. We conclude from this study that the surgeon must know several surgical techniques and choose the most applicable one during operation. The overwhelming majority of cases can be resolved by the Shouldice operation. For elderly patients, the Lichtenstein operation is an appropriate alternative. For cases with large defects of the posterior wall we can choose between Lichtenstein operation, the laparoscopic procedures and transinguinal preperitoneal mesh plasty.

Adult↗
PubMed2001

[Partial versus total gastrectomy in the surgical treatment of stomach cancer].

The authors discuss some aspects of radical gastrectomy. They analyse whether there is any progress in their results in the treatment of stomach cancer in the past 5 years. They describe some aspects of total gastrectomy with regards to the need for splenectomy. During 36 years (01.07.1952-30.06.1962 and 1974-1999) 1614 patients were treated for stomach cancer. In the last two 5 year long periods (1990-1994 and 1995-1999) the number of radical operations was 106 and 114. In the second period we used laparoscopic exploration in some patients. We carried out total gastrectomies with modern suturing devices (AutoSuture Premium Plus CEEA, Proximate ILS Straight Intraluminal Stapler Endo Surgery, TA Premium) without compromising the principles of radicality using Rochard-Aesculap retractor in most patients. We tried to avoid splenectomy when possible. In the past 5 years we carried out lymphadenectomy according to the Japanese classification, excising group I and II lymph nodes. The resectability rate rose in the last 6 years compared to the previous ten year period (55.3%, 36.1%, 48.4%, 64.3%). The ratio of total gastrectomies increased from 8.6% (10 out of 106 resections) to 42.9% (49 out of 114 resections) in the two 5 year periods. Mortality for partial and total gastrectomy were 4.6% (65/3) and 6.1% (49/3). They could preserve the spleen in 32.6% of the cases. We found that laparoscopic exploration rarely influenced the operation. Partial resection in intestinal type stomach cancer should be performed, if a margin of 6 cm can be achieved. If the patient is in good general health, total gastrectomy should be performed unless the size, type and lymph node involvement of the cancer indicated otherwise. We think that increased resectability is related to both increased capabilities and better diagnostic tools. It is important to preserve the spleen where oncology principals allow.

Adult↗
PubMed1998

[Efficiency of electro-hydrothermal coagulation in the management of non-variceal upper gastrointestinal bleeding].

UNLABELLED: The data of 596 electro-hydrothermal coagulations in nonvariceal acute gastrointestinal bleeding were retrospectively evaluated and the results were compared to a previous period in which the endoscopic hemostasis was not regularly applied. Initial hemostasis was achieved in 96.1%, the rebleeding rate was 20.5%, perforation occurred in 0.5%. Comparing the two period the need of urgent surgery decreased from 9.2% to 3.4% (p < 0.05) and the mortality from 25.4% to 12% (p < 0.01). CONCLUSION: The electro-hydro-thermal coagulation is a safe and effective method in the treatment of nonvariceal gastrointestinal bleeding.

Adolescent↗
PubMed1997

Thoracic and lumbar sympathectomy with the application of ROMICRO mini laparotomy set.

The authors present the use of ROMICRO set (originally developed for mini laparotomy) for thoracic and lumbar sympathectomy. They review 3 thoracic and 2 lumbar sympathectomy operations that had good effects and uneventful recoveries. The advantage of the method is that no special instruments are needed and it can be done as a conventional operation.

Cholecystectomy, Laparoscopic↗
PubMed1997

Cholecystectomy through a mini laparotomy alongside laparoscopic technique.

The authors present the surgical treatment of gallstones with special instruments and technique through a mini laparotomy, as developed in Kaposvár (Hungary). Despite the fact that the widespread use of laparoscopic cholecystectomy (LC) has succeeded over open cholecystectomy (OC), in their opinion, there are some instances where cholecystectomy through a mini laparotomy (MLC) would be advantageous. Last year (1996), in the authors' department, 32 MLCs were performed in addition to 72 OCs and 176 LCs. Due to unspecified techniques and differing criteria used to define MLC, it is difficult to find any data related to this subject in the literature available. In Hungary, there are two cities--Kaposvár and Szolnok--where only MLCs are performed for the surgical treatment of gallstones. Conversely, the University hospital of Szeged and the County hospital of Békéscsaba use all three procedures i.e. OC, LC and MLC; as is the case in the authors' hospital. In the article, the pros and cons of MLC are compared to those of LC. (The MLC being more cost effective, enables quick conversion to an OC if required, and provides the surgeon with a three dimensional picture, it is also suitable for the surgical treatment of common bile duct stones. However, it is cosmetically worse, obesity can cause technical difficulties, the incidence of hernia formation is higher, and wound healing is affected.) In the authors' opinion, it would be important to establish set criteria in order to screen patients that are unsuitable for LC, and they attempt to do so in this article.

Cholecystectomy↗
PubMed1995

[Early stage gastric cancer in Vas County].

UNLABELLED: Between 1983 and 1992, 44 patients with early gastric cancer underwent operative treatment. This group comprised 13.3 percent of all patients with gastric cancer operated on during this period. Every patient underwent oesophago-gastro-duodenoscopy before operation. The indication for surgery was histologically confirmed carcinoma in 37 patients, gastric haemorrhage in 2 patients and gastric ulcer unresponsive to medical treatment in 5 patients. The gastric carcinoma was limited to the mucosa in 28 cases and involved the submucosa in 16. Five patients, one with mucosal and four with submucosal early gastric cancer had regional metastatic lymph node involvement. Life-table calculated patient survival rate at 5 years, excluding the perioperative mortality, was 79.4 percent. CONCLUSIONS: 1. The prevalence of early gastric cancer proved to be similar to previously published in West-Europe and United States. 2. If early gastric cancer is limited only to the mucosa, regional metastatic lymph node is relatively rare. 3. Gastrointestinal bleeding can be the first clinical sign of early gastric cancer. 4. Therapy resistant gastric ulcer requires surgery irrespective of the histological examination of the biopsy specimen.

Adult↗
PubMed1994

Prognostic relevance of transforming growth factor alpha (TGF-alpha) and tumor necrosis factor alpha (TNF-alpha) detected in breast cancer tissues by immunohistochemistry.

The function of different growth factors in the development and progression of malignant tumors and the role of cytotoxic cytokines in the host response generated against neoplasms have been recently studied. Anti-TGF-alpha and anti-TNF-alpha monoclonal antibody families have been developed and characterized previously by our laboratory. Libraries of anti-TGF-alpha and anti-TNF-alpha monoclonal antibodies were selected for equal immunoreactivity both in native (frozen) and in formaldehyde fixed, paraffin embedded histological sections. No differences were found between native and fixed samples demonstrated in 10 cases in the present prospective study. Retrospective investigation was performed in 35 histopathological specimens of breast cancer patients detailed clinically and observed during 5 years after the surgical treatment. Correlation between TGF-alpha and/or TNF-alpha expression and clinical staging--TNM score, lymph node metastasis, tumor recurrence and survival time--was analyzed. According to our present study, the TGF-alpha positive patients had worse clinical prognosis than the TNF-alpha positive and double positive cases during long term observation.

Adult↗
PubMed1994

Adjuvant chemotherapy in the treatment of the breast.

The authors reviewed the adjuvant chemotherapeutical treatment after operation of the breast cancer. At their department 6 cycles CMF doses were given to the node positive premenopausal patients. In order to analyse the results a control group was set up. They examined the effect of the treatment concerning the tumour-free survival and survival data. For the calculation the log-rank test--Mantel-Haenszel chi 2-probe was used. The effect of the treatment is favourable.

Breast Neoplasms↗
PubMed1993

[Adjuvant endocrine therapy--Zitazonium--in breast cancer].

The authors deal with the problems of adjuvant therapy of breast cancer. They administrated Zitazonium in those postmenopausal women who had had positive axillary lymph nodes. In the course of analyzing the results, they calculated survival and tumor free survival with "life-table" method, while they used log-rank probe and Mantel-Haenzel X2 probe for showing significance between the diagrams. The results were favourable, but no significant variance could be shown in the group treated with Zitazonium. If lymph nodes were proved to be negative the difference between the graphs were minimal. They refer to the question of steroid receptor determination and emphasize to take into account the biological markers when projecting adjuvant therapy.

Adult↗