Biomedical subjects
Publications and source records attributed to B Möller.
In recent years, lactic acidosis has been described in association with metformin therapy in diabetics. We report a fatal case in an elderly diabetic patient with impaired renal function and cardiac insufficiency. The patient presented with an elevated plasma metformin concentration and a concomitant digitoxin intoxication.
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Intercalating agents, some of them in clinical use, were tested for their ability to inhibit the hepatitis B virus specific DNA polymerase reaction. Ethidium bromide was shown to be the strongest inhibitor among the compounds tested. Compounds in clinical use inhibited the DNA polymerase test only at high concentrations. The inhibitory activity of all compounds tested was increased when the MgCl2 content in the reaction mixture was lowered. UV absorption studies presented no evidence that this effect was due to complex formation of magnesium and the individual compounds. The therapeutic significance of these findings is not certain and needs further work.
Vasoactive intestinal polypeptide (VIP), a neuropeptide with possible neurotransmitter function, was demonstrating in nerves of dental pulps of several mammals including man. The VIP containing nerves were observed around blood vessels and as single terminals in the pulpal stroma. In view of the potent vasodilatory actions of VIP it is conceivable that pulpal VIP nerves take part in the regulation of local blood flow.
From earlier studies using amalgam of known physical and sealing properties it was concluded that the initially high mercury content was the main reason for pulpal changes and that clinical leakage had been less important. The purpose of the present investigation was to study how a possible sealing insufficiency may contribute to the pulpal changes beneath restorations of silver amalgam. The influence of bacteria at the tooth/filling interface upon pulpal changes was also studied. The material consisted of 21 contralateral pairs of premolars. Intermediate depth cavities were prepared in 13 pairs and deep cavities in 8 pairs. All cavities were filled with silver amalgam by the wet technique. The restoration in one tooth of each pair was sealed off by glued metal foil protected by a cemented orthodontic band. After 1 week the teeth were extracted and examined histologically. In the pulp of teeth with restorations exposed to the oral environment, the frequency of dilated capillaries and inflammatory cells in the odontoblast - cell-rich zone boundary, associated with the dentinal tubules involved in the cavity preparation, was insignificantly higher statistically than in those with seal-off restorations. A few scattered bacteria were found on the cavity wall in some cases. It was concluded that, in the short run, the pulp reaction was influenced by sealing insufficiency, which may develop during the experimental period as a result of external factors such as tooth deformation and/or changes in temperature. No influence from bacteria on the cavity wall could be established.
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Twenty one patients with either paroxysmal supraventricular tachycardia (group A), atrial flutter (group B), or atrial fibrillation (group C) were treated with intravenous metoprolol in the dose range 2--20 mg. Sinus rhythm was restored in 3 out of 6 patients in group A, 3 out of 7 patients in group B and one out of 8 patients in group C. In patients who did not convert to sinus rhythm a remarkable decrease in ventricular rate occurred in 3 patients with atrial flutter and 4 patients with atrial fibrillation. In patients with systolic blood pressure greater than 100 mm Hg but without an acute myocardial infarction the risk of hypotension necessitating treatment was small. Metoprolol appears to be an effective and safe drug in the treatment of supraventricular tachycardia.
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On the basis of the findings from 1470 patients referred for orthodontic treatment, the authors analyse, for various types of anomalies, the sequelae of untreated proximal caries and premature extractions in the supporting areas of the upper and the lower jaw. The results obtained indicate that the premature loss of deciduous teeth causes, in case of malalignment associated with lack of space, secondary alterations.
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