PubMed Health⌕ Search

Biomedical subjects

B Macartney

Publications and source records attributed to B Macartney.

6 recordsLinked to original sources
PubMed1983

A dose-response study on fenoterol (Berotec) solution by inhalation in asthmatic children.

Fenoterol (Berotec) was administered by inhalation, using a Bennett nebulizer, to symptom-free asthmatic children aged 6-13 years. It was demonstrated in a double-blind, crossover trial in 6 children that the improvement in the forced expiratory volume produced by inhalation of a nebulised fenoterol solution was not a placebo effect. Fenoterol (0.1 mg) produced effective bronchodilatation but there was a significant logarithmic dose-response relationship over the dose range tested (0.1-0.8 mg cumulative). There was no effect of the drug on heart rate even with the 0.8 mg dose.

Adolescent↗
PubMed1981

Terbutaline aerosol in the long-term treatment of asthmatic children.

Ten asthmatic children received regular daily therapy with terbutaline aerosol for 50 weeks. No evidence was found for adverse effects of this drug on growth, bone marrow, liver function or the cardiovascular system. All children had improved respiratory function throughout the year. In acute experiments carried out in 12 symptom-free asthmatic children with 0.5 mg terbutaline, it was demonstrated that the improvement in respiratory function, i.e. increase in FEV1, MMEF25-75%, FVC and PEF, was quick in onset, was maintained for at least 60 min and was not accompanied by effects on pulse rate. Thus, the bronchodilator aerosol, terbutaline, can be safely used as a regular daily therapy in asthmatic children aged 7 to 14 years.

Aerosols↗
PubMed1978

The acute effects of the administration of rimiterol aerosol in asthmatic children.

1 Ten asthmatic children received on two separate occasions rimiterol (500 microgram) and orciprenaline (1.5 mg) as aerosols in a double-blind, crossover design trial. Respiratory parameters (FEV1, FVC and PEFR) and pulse rate were recorded for 60 min after each administration. 2 Rimiterol produced effective bronchodilation in children with negligible cardiac stimulation. It differed from orciprenaline in that the peak bronchodilator effect was not maintained during the 60 min observation period. 3 Rimiterol is a selective, short-acting, sympathomimetic bronchodilator in children.

Aerosols↗