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Biomedical subjects

B Madrigal Rubiales

Publications and source records attributed to B Madrigal Rubiales.

11 recordsLinked to original sources

[External ear melanoma].

Cutaneous melanomas are the tumours that have increased more their incidence in the last fifty years. Melanomas arising from the external auditory canal are extraordinariously unfrequent. These tumours show an aggressive and silent behaviour, and due to this the diagnosis is frequently made in an advanced stage. A male with a malignant melanoma arising from his left external auditory canal was attended in our department, suspecting an epidermoid carcinoma. The clinical findings and the extension of the lesion required a lateral temporal bone resection, parotidectomy and neck dissection to achieve a total resection. We present a review of the literature about this entity and an analysis of the incidence, significance of the lymph node metastases and value of the elective neck dissection.

Ear Neoplasms↗

[Idiopathic retroperitoneal fibrosis].

OBJECTIVE: A case of idiopathic retroperitoneal fibrosis in a 34-year-old man with anemia and elevated erythrocyte sedimentation rate is presented. METHODS/RESULTS: Ultrasound, CT and MRI evaluation and pathological study were performed. These diagnostic imaging techniques demonstrated an infiltrating mass in the upper portion of the abdomen which was resected. Histological and immunohistochemical studies of the surgical specimen demonstrated sclerosing retroperitonitis. CONCLUSIONS: Idiopathic retroperitoneal fibrosis (Ormond's disease) is a rare disease entity whose etiology is obscure and is characterized by retroperitoneal fibrosis with inflammatory infiltrates composed of plasma cells, lymphocytes and eosinophils. This case is of interest due to its atypical location, and because the patient was young with no remarkable clinical history and only mild anemia and an elevated erythrocyte sedimentation rate.

Adult↗

[Retroperitoneal ganglioneuroma in childhood].

OBJECTIVE: An incidentally discovered retroperitoneal ganglioneuroma in a 4-year-old child is presented. METHODS: Ultrasonography and CT were performed. The surgical specimen was analyzed by macroscopic, histological and immunohistochemical techniques. RESULTS: US and CT localized a retroperitoneal mass independent from the left kidney and adrenal gland. The histological study showed a fascicular proliferation with myxoid and fibrillar areas mixed with mature ganglion cells. These cells were positive for neurofilament and neuron specific enolase. The patient had a favorable outcome with no signs of tumor recurrence. CONCLUSIONS: Ganglioneuroma is a rare, completely mature tumor that has to be differentiated from neuroblastoma.

Child, Preschool↗

[Persistent leucocytosis as initial manifestation of Whipple's disease and development of gastric cancer in the follow up].

We report the case of a 57 year old male with Whipple's disease. The patient was asymptomatic and an unexplained peripheral leucocytosis was found in a routine examination. It persisted as the only abnormality for one year and then he developed articular symptoms, diarrhoea and weight loss. The diagnosis was confirmed by duodenal biopsy five years later. The leucocyte count ranged between 14,000 and 22,000 leuc/mm3. Response to cotrimoxazole was favourable with disappearance of all signs and symptoms, including leucocytosis. In the last endoscopic control, eight years after initial manifestations, an intramucosal gastric adenocarcinoma was diagnosed.

Adenocarcinoma↗

[An intimal sarcoma of the pulmonary artery. An immunohistochemical study].

Pulmonary artery intimal sarcomas tend to be presented with symptoms of pulmonary thromboembolism and grow regionally, with little capacity to metastasize. They probably originate from subendothelial cells, that become myofibroblasts. Knowledge of it is important to establish a presurgery diagnosis, with the possibility of a total resection, the only useful treatment until now. We report a case of a pulmonary artery primary sarcoma, in a 73 year old woman, admitted with hemoptysis and pleuritic chest pain, who died ten days after. Autopsy revealed an intraluminal mass at the pulmonary artery trunk, without regional nor distance involvement. Microscopic study showed a pleomorphic tumor with spindle and epithelioid cells, positive for actin, desmin and vimentin. All these data support the diagnosis of primary intimal sarcoma of the pulmonary artery. We want to emphasize the myogenic differentiation of the tumor, uncommon in previously reported cases.

Aged↗

[Extramedullary anaplastic plasmacytoma].

A case of extramedullary plasmacytoma of the maxillary sinus, locally aggressive, in a 65 years old man is presented. Clinical diagnosis of adenocarcinoma was suspected but the pathological study showed an anaplastic morphology, with little plasmacytic differentiation and lack of stain with cytokeratins and epithelial membrane antigen (EMA), immunohistochemical marker of plasmatic cells, among others. Definitive diagnosis was based on light chain restriction and lack of multiple myeloma.

Adenocarcinoma↗

[Mucinous adenocarcinoma of the prostate. Report of 3 cases and review of the literature].

OBJECTIVES: To describe 3 cases of mucinous adenocarcinoma, an uncommon variant of prostatic adenocarcinoma, and review the literature. METHODS: 3 cases of mucinous adenocarcinoma of the prostate are described. The histological and immunohistochemical features, diagnostic and therapeutic aspects of this variant of prostatic adenocarcinoma are presented and the literature briefly reviewed. RESULTS/CONCLUSIONS: This variant of prostatic adenocarcinoma is characterized by the presence of extra and intracellular mucus formation. It is generally seen in the advanced stages and responds poorly to any form of therapy.

Adenocarcinoma, Mucinous↗

[Adrenal gland myelolipoma: radiological view].

OBJECTIVE: To report a case of adrenal myelolipoma in a female patient with a history of arterial hypertension and increased plasma aldosterone levels. METHODS: Evaluation by CT and ultrasound, and anatomopathological analysis were performed. RESULTS: The CT and ultrasound scans showed a fat-containing adrenal mass. The patient underwent surgery. Histological analysis of the surgical specimen demonstrated a myelolipoma, a benign tumor composed in varying proportions of adipose and hematopoietic tissue. CONCLUSIONS: A diagnosis of adrenal myelolipoma must be considered when a fat-containing adrenal mass is demonstrated by ultrasound, CT or MRI.

Adrenal Gland Neoplasms↗

[Granulomatous prostatitis. Review of 22 cases].

Granulomatous prostatitis is an uncommon inflammatory process of the prostate, which can be caused by a variety of infectious agents or be part of a systemic allergic condition. In most cases, origin is unspecific. Clinical presentation, treatment and evolution are similar to those of benign prostatic hypertrophy and, in many cases, can only be distinguished from prostate carcinoma in the histological study. The authors present in this paper the results and conclusions of a retrospective study of 22 cases of granulomatous prostatitis.

Granuloma↗