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Biomedical subjects

B Malek

Publications and source records attributed to B Malek.

9 recordsLinked to original sources
PubMed1994

[Solitary subcutaneous metastasis of a chondrosarcoma].

We report on a rare case of a solitary subcutaneous metastasis from a chondrosarcoma. The metastasis occurred 7 years after excision of the primary neoplasm. Further investigations revealed no evidence of other metastases. Nevertheless, according to data in the literature, the prognosis has to be considered very poor.

Aged↗
PubMed1989

Regional distribution of opioidergic nerves in human and canine prostates.

The regional distribution of opioidergic nerves in the juvenile and adult human prostate and in the adult canine prostate has been studied immunohistochemically using well-characterized polyclonal antisera against multiple opioid peptides. Nerves displaying immunoreactivity (ir) for the proenkephalin (PRO-ENK) derivatives met-enkephalin (ME), leuenkephalin (LE), octapeptide, and heptapeptide (ordered in decreasing frequency) were present in the dorsolateral stroma of human prostate. In canine prostate, the situation was similar, but the number of opioid-ir nerve fibers was lower than in human prostate. In both species, staining for the prodynorphin (PRO-DYN) derivatives dynorphin A and alpha-neoendorphin or staining for the pro-opiomelanocortin (POMC)-derived beta-endorphin was not visualized. In addition to their presence in nerve fibers, PRO-ENK-ir opioids (octapeptide) occurred in intrinsic ganglionic cells situated in the capsule. Octapeptide but not LE-ir fibers supplied stromal blood vessels. The periurethral region and tissue adjacent to the ejaculatory ducts appeared to be devoid of opioid-ir innervation. We conclude that endogenous opioids apparently exclusively derived from PRO-ENK may fulfill important comessenger functions in the fine regulation of prostatic stromal tonus and of local vascular perfusion.

Adolescent↗
PubMed1989

Age-dependency and regional distribution of enkephalinergic nerves in human prostate.

The regional distribution of peptidergic nerves in the juvenile and adult human prostate has been studied immunohistochemically using highly specific polyclonal antibodies. Nerves displaying immunoreactivity of Met-enkephalin, Leu-enkephalin, heptapeptide and octapeptide were detected in the dorsolateral stroma closely related to smooth muscle predominantly of juvenile glands. A less strong immunoreactivity was present around stromal vessels and periurethral. Subepithelial peri-acinar nerves showing Leu-enkephalin, Met-enkephalin, octa- and heptapeptide immunoreactivity were found in a few instances. The most prominent immunoreaction was achieved with octapeptide antiserum, followed in decreasing order by Met-enkephalin, Leu-enkephalin and heptapeptide. Their density decreased with age. Antisera against beta-endorphin, alpha-neoendorphin, beta-neoendorphin and dynorphin A gave to positive immunoreaction with prostatic nerves. The regional distribution pattern described is in favor of a postsynaptic peptidergic sympathetic innervation of prostatic stroma acting with classical neurotransmitters.

Adolescent↗
PubMed1988

[Femoral neck fractures--treatment and results at a general surgery department].

This is a report about 50 fractures of the femoral neck, treated in a ward for general surgery. Impacted valgus fractures generally do not need surgery. Osteosynthesis only with Böhler nail have no good results. Hemiprosthesis of femoral head on elderly patients is a good method and generally not followed by protrusio acetabuli.

Adult↗