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Biomedical subjects

B Malinowska

Publications and source records attributed to B Malinowska.

At least 55 records · Page 3Linked to original sources
PubMed1990

Influence of acute and chronic ethanol administration on the vasopressor effect of serotonin in pithed rats.

In pithed rats, the intravenous administration of serotonin (3, 10, 30, 100, 300 and 1,000 micrograms/kg) produced a dose-dependent increase in blood pressure. This action of 5-HT was not changed by chronic ethanol intoxication (6.0 g/kg/day for 2 weeks). The pressor responses to serotonin were, in a dose-dependent manner, significantly reduced by acute ethanol administration (0.5, 1.0, 2.0 and 4.0 g/kg p.o.) and by ketanserin injection (0.03 mg/kg i.v.). However, ethanol (2.0 g/kg) did not amplify the dilator effect of serotonin in pithed rats pretreated with ketanserin (3.0 mg/kg i.v.). We also demonstrated that, in contrast to ketanserin (10(-7) mol/l), ethanol (0.05 mol/l) potentiated the serotonin-induced vasoconstriction of isolated rat tail arteries. These data suggest that the action of ethanol on the vasopressor effect of serotonin in pithed rats does not depend on its influence on serotonergic receptors in blood vessels.

Animals↗
PubMed1990

The serotonergic mechanisms are not involved in the inhibitory effect of captopril on rat platelet aggregation.

The influence of captopril on blood platelet aggregation and on serotonergic mechanisms in blood platelets were studied. In rats pretreated with captopril (10.0 mg/kg p.o.) platelet aggregation induced by ADP and collagen was significantly reduced. In vitro this drug had no inhibitory effect. Besides, captopril did not change the amplifying effect of serotonin on platelet aggregation. Captopril also had no influence on the uptake and storage of 5-hydroxytryptamine by rat blood platelets. These results show that serotonergic mechanisms are not involved in the suppressive effect of captopril on platelet aggregation.

Adenosine Diphosphate↗
PubMed1990

[Lymph nodes in cancer of the tongue].

The results of lymphnodes examinations in 59 patients operated upon because of the lingual cancer were described. In 39% of cases the metastases were found on the side of lesions. In 31 of patients with palpable lymphnodes the metastases were found in 54.8% of cases. In 28 patients without palpable lymphnodes the metastases were found in 21.4% of cases. Thus 45.2% cases were false positive and 21.4 false negative. In lingual marginal localizations of lesions the metastases were found more frequently as well as in more developed clinical stages. In these patients because of the frequent false positive lymphnodes the radical neck dissection should be performed, in special cases also bilaterally.

Adult↗
PubMed1990

[Primary cancer of the tongue treated at the Otolaryngological Clinic, Medical Academy, in Poznań 1963-1987].

The analysis of 191 patients with primary tongue carcinoma treated in ENT Clinic of Medical Academy in Poznań during the years 1963-1987 was presented. Since 1983 there were the dramatic increase in patients number. The patients age was between 20 and 87. Statistically significant was the males number. The half of the patients were in their 6th decade of life. In the last 5 years period the patients were younger of mean 5 years. Their symptoms lasted about 4 months. The earliest was the tongue pain. Tobacco smokers and alcoholics predominated. The localizations were in general on the edge and on the basal part of the tongue. Histologically the most frequent was the planoepithelial cancer in the second clinical stage. The 5 years survival rate was about 20%.

Adult↗
PubMed1989

Cardiovascular effects of ethanol in anaesthetized, conscious and pithed rats.

The influence of ethanol (2.0 g/kg p.o.) on heart rate and blood pressure in anaesthetized, conscious and pithed rats was studied. In anaesthetized rats we observed an increase in heart rate and a marked and very sudden decrease in blood pressure. In pithed rats blood pressure decreased more slowly than in anaesthetized and conscious animals and there were no changes in heart rate. These results show that the central nervous system may be responsible for the increase in heart rate and early phase of hypotension caused by acute ethanol administration. The slower decrease (up to 1 h) in blood pressure may be caused by central and different indirect peripheral mechanisms.

Anesthesia↗
PubMed1989

Influence of captopril on the vasopressor effect of serotonin in pithed rats.

In pithed rats intravenous administration of serotonin (5.0, 10.0, 20.0, 30.0 and 50.0 micrograms/kg) produced a dose-dependent increase in blood pressure. The pressor response to serotonin was significantly reduced by captopril (1.0, 5.0 and 50.0 mg/kg) in a dose-dependent manner. Captopril did not attenuate the response of the isolated tail artery to serotonin (5-HT) and did not amplify the dilator effect of serotonin in pithed rats pretreated with ketanserin (1.0 mg/kg). These data suggest that the action of captopril does not depend on its influence on serotoninergic receptors in blood vessels.

Animals↗
PubMed1989

[Effect of Polfos on the bleeding time. III. Changes in various parameters of the circulatory system].

The influence of Polfos on the blood pressure in rats was measured by direct and indirect methods. The influence of this pesticide on the heart rate was also examined. Two hours after Polfos administration an increase in blood pressure and a decrease in heart rate were observed. In the late phase of Polfos-intoxication no changes in the cardiovascular system were found. The results show that prolonged bleeding time in the initial phase of the intoxication might depend on its influence on the cardiovascular system in rats.

Animals↗
PubMed1989

[Effect of Polfos on the bleeding time. II. Changes in selected parameters of the blood coagulation system and fibrinolysis].

The influence of Polfos on some parameters of the coagulation system and fibrinolysis in rats was examined. The present results indicate that Polfos had no effect on the coagulation system and fibrinolysis in the initial phase of intoxication (2 hours). In the late phase of intoxication (24 hours) a decrease in the prothrombin index, shortening of thrombin time, increase in the fibrinogen level and prolongation of euglobulin lysis time were observed. The results demonstrate that the normalization of the bleeding time in the late phase of intoxication depended on activation of the coagulation system and inhibition of fibrinolysis activation.

Animals↗
PubMed1988

[Effect of Polfos on bleeding time. I. Changes in the formed elements of the blood in rats exposed to Polfos].

The influence of Polfos and its metabolite, 2,4 dichlorophenacyl bromide, on the bleeding time, count of platelets, platelets aggregation, count of erythrocytes, level of haemoglobin and count of leucocytes in rats were studied. The data indicate that Polfos prolonged the bleeding time in the 2nd hour after its administration. A decrease of the platelets count was observed only in the initial phase of the intoxication. In the study the platelets count, red cells count, hematocrit and the level of haemoglobin increased 24 hours after the administration of the pesticide. The results demonstrate that the prolongation of the bleeding time in the rats after the administration of Polfos partly depends on the changing of the platelets count.

Animals↗